NMD-VCell Research Workbench Module: Validate / registry · evidence-to-experiment workflow NMD = neuromuscular disorders
v1.0 candidate Frozen 25 Jul 2026 DOI pending
v1.0.0-database-resource Schema 1.1 Model ridge-safe-v2.3 Benchmark repeated-fold-v2.2 Build EA-20260729-15 v1.0 is a database and evidence-governance release; it is not a validated disease-prediction or clinical decision-support release.
Current evidence ceiling L2 observed HepG2 limited L3a context No independent DMD perturbation validation Open boundary

Validate · research-object registry

Lifecycle state is evidence, too.

This registry distinguishes a design draft from an immutable registration, a registered prediction from a measured outcome, and an absent record from a negative result.

Gene objects17,921 released
Comparison objects5 released
Study Cards21 draft
Scientific program1 released contract
Registered studies0
Running experiments0
v1 release gate1 released
Prediction readiness1 released gate
Prediction registry1 empty scaffold
Predictions0 registered
Outcomes0 measured
Release objectv1.0.0-database-resource

Lifecycle rail

Draft objects are not failed validations

DRAFT21Study Cards
REGISTERED0Awaiting signed protocol identity
RUNNING0No in-flight prospective experiment
MEASURED0No outcome linked
RELEASED0No validated experiment object

Released examples

Frozen comparisons with rendered results

These objects resolve without a query string or client-side JavaScript. Each preserves inputs, mappings, release identity, checksum, JSON and TSV.

Immutable worked examples; no ranking generated
Object IDPurposeGenesState
CMP-20260726-A9A727B87722 Three-gene evidence-gap comparisonZNF133, MON1A, GFOD2 RELEASED
CMP-20260726-644BCF7470F4 Shared-action comparisonZNF133, MON1A RELEASED
CMP-20260726-635CEE3B9163 External-context contrastGFOD2, ZFP69B, CPEB1 RELEASED
CMP-20260726-61BB5BEE5251 Computational-replication queueINTS13, NAGLU, RNF8 RELEASED
CMP-20260726-1DF261243518 Mixed action and gap comparisonZNF133, WDR4, GFOD2, INTS13 RELEASED

Lifecycle contract

Draft → registered → measured → superseded

DRAFTEditable planning object
REGISTEREDImmutable; timestamp and checksum required
MEASUREDOutcome linked without overwriting prediction
SUPERSEDEDNew revision links to prior object
Current boundary. This static public beta exposes read-only contracts and draft objects. It does not accept uploads or claim registry persistence without an approved storage, identity and governance policy.

Released governance object

PredictionReadiness gate

PREAD:v1.0.0-database-resource:EA-20260729-15 is a released governance object. It states that P0 infrastructure is available, P1 research-use DMD prediction is locked pending independent disease-relevant perturbation validation, and P2 clinical prediction is outside the current release.

Open rendered object · Open JSON

Released scientific contract

State-transition program and DMD Minimum Perturbome

PROGRAM:v1.0.0-database-resource:STATE-TRANSITION:1.0 defines the dual-track scientific program. The 24-slot Minimum Perturbome remains a draft protocol: 0 genes assigned, 0 registered studies, 0 experiments and 0 outcomes.

Open scientific program · Open draft pilot · Registered Study registry · Outcome registry

Released publication objects

V1ReleaseGate, ExternalAuthorizationDossier and PredictionRegistry

V1GATE:v1.0.0-database-resource:EA-20260729-15 records formal database-paper readiness without authorizing formal v1.0. AUTHD:v1.0.0-database-resource:EA-20260729-15 records the DOI/licence/maintainer dossier that remains pending external input. PREG:v1.0.0-database-resource:EA-20260729-15 records the empty prospective prediction registry; it has 0 predictions and 0 measured outcomes.

Open v1 gate · Open authorization dossier · Open prediction registry

Governed hypotheses

All 21 Study Cards remain drafts

Draft Study Cards; alphabetical, not ranked
Object IDTypeGeneStateCurrent action
SC:v1.0.0-database-resource:ADAM10:1.5-DRAFT StudyCardADAM10DRAFT Computational replication
SC:v1.0.0-database-resource:CALR:1.5-DRAFT StudyCardCALRDRAFT Computational replication
SC:v1.0.0-database-resource:CPEB1:1.5-DRAFT StudyCardCPEB1DRAFT Verify expression
SC:v1.0.0-database-resource:DDX19B:1.5-DRAFT StudyCardDDX19BDRAFT Computational replication
SC:v1.0.0-database-resource:DNAAF3:1.5-DRAFT StudyCardDNAAF3DRAFT Verify expression
SC:v1.0.0-database-resource:DNM1:1.5-DRAFT StudyCardDNM1DRAFT Computational replication
SC:v1.0.0-database-resource:EHMT2:1.5-DRAFT StudyCardEHMT2DRAFT Computational replication
SC:v1.0.0-database-resource:EPS8L1:1.5-DRAFT StudyCardEPS8L1DRAFT Verify expression
SC:v1.0.0-database-resource:GFOD2:1.5-DRAFT StudyCardGFOD2DRAFT Provisional hold · external report not yet audited
SC:v1.0.0-database-resource:INTS13:1.5-DRAFT StudyCardINTS13DRAFT Risk/context review
SC:v1.0.0-database-resource:LMO2:1.5-DRAFT StudyCardLMO2DRAFT Computational replication
SC:v1.0.0-database-resource:MON1A:1.5-DRAFT StudyCardMON1ADRAFT Muscle-context assay
SC:v1.0.0-database-resource:MPHOSPH6:1.5-DRAFT StudyCardMPHOSPH6DRAFT Computational replication
SC:v1.0.0-database-resource:NAGLU:1.5-DRAFT StudyCardNAGLUDRAFT Risk/context review
SC:v1.0.0-database-resource:RAC3:1.5-DRAFT StudyCardRAC3DRAFT Risk/context review
SC:v1.0.0-database-resource:RNASEH2C:1.5-DRAFT StudyCardRNASEH2CDRAFT Risk/context review
SC:v1.0.0-database-resource:RNF8:1.5-DRAFT StudyCardRNF8DRAFT Risk/context review
SC:v1.0.0-database-resource:WDR4:1.5-DRAFT StudyCardWDR4DRAFT Risk/context review
SC:v1.0.0-database-resource:ZFP69B:1.5-DRAFT StudyCardZFP69BDRAFT Verify expression
SC:v1.0.0-database-resource:ZNF133:1.5-DRAFT StudyCardZNF133DRAFT Muscle-context assay
SC:v1.0.0-database-resource:ZNF236:1.5-DRAFT StudyCardZNF236DRAFT Risk/context review

Machine contract

Strict object schemas, transition rules and null semantics are published separately from the frozen schema 1.1 gene API.

Manifest · Schemas · Registry JSON

Operational readiness

Reproducibility, maintenance, structured-metadata and accessibility targets are explicit objects, including unresolved institutional gates.

Reproducibility · Maintenance · Accessibility