[
  {
    "broad_essential_flag": "False",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "ALS4/ataxia",
    "gene": "SETX",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "rna_dna_helicase",
    "moderate_dependency_flag": "False",
    "n_cells": "92",
    "nar_claim_language": "Can support direct perturbation-response and benchmark interpretation in current HepG2 TRADE context.",
    "next_data_need": "Add disease-relevant muscle or neuron context for biological specificity.",
    "rescue_score": "-0.057956",
    "support_level": "direct_benchmarkable",
    "support_score": "3.3057",
    "top_neighbor_cosine": "0.385661",
    "top_neighbor_gene": "SCAP"
  },
  {
    "broad_essential_flag": "True",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "ALS",
    "gene": "TARDBP",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "rna_binding",
    "moderate_dependency_flag": "True",
    "n_cells": "262",
    "nar_claim_language": "Can support boundary analysis; direct response exists but needs caution from low cell count or safety/dependency flags.",
    "next_data_need": "Increase perturbation support or validate in a more relevant context.",
    "rescue_score": "0.000761",
    "support_level": "direct_low_power_or_caution",
    "support_score": "3.1551",
    "top_neighbor_cosine": "0.647534",
    "top_neighbor_gene": "TSG101"
  },
  {
    "broad_essential_flag": "True",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "ALS",
    "gene": "SOD1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "motor_neuron_oxidative",
    "moderate_dependency_flag": "True",
    "n_cells": "24",
    "nar_claim_language": "Only sparse perturbation evidence; use as coverage boundary, not a predictive claim.",
    "next_data_need": "Need stronger perturbation support before candidate prioritization.",
    "rescue_score": "-0.019093",
    "support_level": "direct_sparse_boundary",
    "support_score": "1.0546",
    "top_neighbor_cosine": "0.314620",
    "top_neighbor_gene": "PABPC1"
  },
  {
    "broad_essential_flag": "",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "ALS/FTD",
    "gene": "C9orf72",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "repeat_expansion",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "ALS",
    "gene": "FUS",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "rna_binding",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "distal myopathy/ALS overlap",
    "gene": "MATR3",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "rna_binding",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "CMT/ALS overlap",
    "gene": "NEFL",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "neurofilament",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "multisystem proteinopathy/ALS overlap",
    "gene": "SQSTM1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "autophagy",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "ALS/FTD-spectrum",
    "disease_group": "distal myopathy/ALS overlap",
    "gene": "TIA1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "rna_binding",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "CMT/peripheral-neuropathy",
    "disease_group": "centronuclear myopathy/CMT",
    "gene": "DNM2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "membrane_trafficking",
    "moderate_dependency_flag": "",
    "n_cells": "14",
    "nar_claim_language": "Only sparse perturbation evidence; use as coverage boundary, not a predictive claim.",
    "next_data_need": "Need stronger perturbation support before candidate prioritization.",
    "rescue_score": "",
    "support_level": "direct_sparse_boundary",
    "support_score": "2.7586",
    "top_neighbor_cosine": "0.618612",
    "top_neighbor_gene": "ATP6V1A"
  },
  {
    "broad_essential_flag": "",
    "disease_family": "CMT/peripheral-neuropathy",
    "disease_group": "CMT/dHMN",
    "gene": "HSPB1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "chaperone",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "CMT/peripheral-neuropathy",
    "disease_group": "CMT/dHMN",
    "gene": "HSPB8",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "chaperone",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "DMD/BMD",
    "disease_group": "Duchenne/Becker muscular dystrophy",
    "gene": "DMD",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "muscle_membrane",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "DMD/BMD",
    "disease_group": "sarcoglycanopathy/LGMD",
    "gene": "SGCA",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "dystrophin_complex",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "DMD/BMD",
    "disease_group": "sarcoglycanopathy/LGMD",
    "gene": "SGCB",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "dystrophin_complex",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "DMD/BMD",
    "disease_group": "sarcoglycanopathy/LGMD",
    "gene": "SGCD",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "dystrophin_complex",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "DMD/BMD",
    "disease_group": "sarcoglycanopathy/LGMD",
    "gene": "SGCG",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "dystrophin_complex",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "False",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "spinal muscular atrophy modifier",
    "gene": "SMN2",
    "in_candidate_screen_v2": "True",
    "in_hepg2_trade": "True",
    "mechanism_group": "motor_neuron_rna",
    "moderate_dependency_flag": "False",
    "n_cells": "452",
    "nar_claim_language": "Can support direct perturbation-response and benchmark interpretation in current HepG2 TRADE context.",
    "next_data_need": "Add disease-relevant muscle or neuron context for biological specificity.",
    "rescue_score": "-0.031394",
    "support_level": "direct_benchmarkable_candidate_queue",
    "support_score": "5.9073",
    "top_neighbor_cosine": "0.907321",
    "top_neighbor_gene": "GEMIN5"
  },
  {
    "broad_essential_flag": "True",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "SMA-LED/CMT",
    "gene": "DYNC1H1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "motor_neuron_transport",
    "moderate_dependency_flag": "True",
    "n_cells": "35",
    "nar_claim_language": "Can support boundary analysis; direct response exists but needs caution from low cell count or safety/dependency flags.",
    "next_data_need": "Increase perturbation support or validate in a more relevant context.",
    "rescue_score": "-0.026512",
    "support_level": "direct_low_power_or_caution",
    "support_score": "1.1187",
    "top_neighbor_cosine": "0.268720",
    "top_neighbor_gene": "TUBGCP2"
  },
  {
    "broad_essential_flag": "",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "SMA-LED",
    "gene": "BICD2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "motor_neuron_transport",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "CMT/SMA",
    "gene": "GARS1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "trna_synthetase",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "SMARD1",
    "gene": "IGHMBP2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "helicase",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "spinal muscular atrophy",
    "gene": "SMN1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "motor_neuron_rna",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "SMA/motor-neuron",
    "disease_group": "motor neuron disease",
    "gene": "VRK1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "kinase",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "True",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "GMPPB",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "True",
    "n_cells": "36",
    "nar_claim_language": "Can support boundary analysis; direct response exists but needs caution from low cell count or safety/dependency flags.",
    "next_data_need": "Increase perturbation support or validate in a more relevant context.",
    "rescue_score": "0.036720",
    "support_level": "direct_low_power_or_caution",
    "support_score": "1.7548",
    "top_neighbor_cosine": "0.527556",
    "top_neighbor_gene": "DHDDS"
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "actin myopathy/nemaline myopathy",
    "gene": "ACTA1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "ANO5 myopathy/LGMD",
    "gene": "ANO5",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "membrane_repair",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "B3GALNT2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "myofibrillar myopathy",
    "gene": "BAG3",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "protein_quality_control",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "centronuclear myopathy",
    "gene": "BIN1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "t_tubule",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "calpainopathy/LGMD",
    "gene": "CAPN3",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "protease_sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "collagen VI myopathy",
    "gene": "COL6A1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "extracellular_matrix",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "collagen VI myopathy",
    "gene": "COL6A2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "extracellular_matrix",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "collagen VI myopathy",
    "gene": "COL6A3",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "extracellular_matrix",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "CRPPA",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "LGMD/myofibrillar myopathy",
    "gene": "DNAJB6",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "protein_quality_control",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dysferlinopathy/LGMD",
    "gene": "DYSF",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "membrane_repair",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "FHL1 myopathy",
    "gene": "FHL1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy/LGMD",
    "gene": "FKRP",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "GNE myopathy",
    "gene": "GNE",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sialic_acid",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "LARGE1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "LMNA-related muscular dystrophy/cardiomyopathy",
    "gene": "LMNA",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "nuclear_envelope",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "myotubular myopathy",
    "gene": "MTM1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "phosphoinositide",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "myosin myopathy",
    "gene": "MYH2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "myosin myopathy/cardiomyopathy",
    "gene": "MYH7",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "nemaline myopathy",
    "gene": "NEB",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "POMGNT1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "POMGNT2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "POMT1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "dystroglycanopathy",
    "gene": "POMT2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "glycosylation",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "RYR1 congenital myopathy",
    "gene": "RYR1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "excitation_contraction",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "SEPN1-related myopathy",
    "gene": "SELENON",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "er_stress",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "distal arthrogryposis/myopathy",
    "gene": "TNNI2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "nemaline myopathy",
    "gene": "TNNT1",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "nemaline/congenital myopathy",
    "gene": "TPM2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "nemaline/congenital myopathy",
    "gene": "TPM3",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "muscular-dystrophy/myopathy",
    "disease_group": "titinopathy",
    "gene": "TTN",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "sarcomere",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "multisystem proteinopathy/IBM",
    "gene": "VCP",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "True",
    "mechanism_group": "protein_quality_control",
    "moderate_dependency_flag": "",
    "n_cells": "8",
    "nar_claim_language": "Only sparse perturbation evidence; use as coverage boundary, not a predictive claim.",
    "next_data_need": "Need stronger perturbation support before candidate prioritization.",
    "rescue_score": "",
    "support_level": "direct_sparse_boundary",
    "support_score": "2.8117",
    "top_neighbor_cosine": "0.731718",
    "top_neighbor_gene": "NPLOC4"
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "caveolinopathy",
    "gene": "CAV3",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "membrane",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "desminopathy",
    "gene": "DES",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "myofibrillar",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "filaminopathy",
    "gene": "FLNC",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "myofibrillar",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "merosin-deficient congenital muscular dystrophy",
    "gene": "LAMA2",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "extracellular_matrix",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "myotilinopathy",
    "gene": "MYOT",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "myofibrillar",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  },
  {
    "broad_essential_flag": "",
    "disease_family": "other-neuromuscular",
    "disease_group": "plectinopathy",
    "gene": "PLEC",
    "in_candidate_screen_v2": "False",
    "in_hepg2_trade": "False",
    "mechanism_group": "cytoskeleton",
    "moderate_dependency_flag": "",
    "n_cells": "",
    "nar_claim_language": "Not supported by the current HepG2 perturbation atlas.",
    "next_data_need": "Need disease-relevant external signature or perturbation dataset.",
    "rescue_score": "",
    "support_level": "not_supported_current_atlas",
    "support_score": "0.0000",
    "top_neighbor_cosine": "",
    "top_neighbor_gene": ""
  }
]
