{
  "contract_schema": "nmd-vcell-generalization-ladder/1.0",
  "object_id": "GENLADDER:v1.0.0-database-resource:EA-20260729-15",
  "resource_release": "v1.0.0-database-resource",
  "interface_build": "EA-20260729-15",
  "tracks": [
    "competition_generalist",
    "dmd_scientific"
  ],
  "levels": [
    {
      "level": "G0",
      "task": "Random-cell split in one context",
      "state": "DEBUG_ONLY_NOT_PRIMARY"
    },
    {
      "level": "G1",
      "task": "Same context, unseen perturbation target",
      "state": "IMPLEMENTED_HEPG2"
    },
    {
      "level": "G2",
      "task": "Unseen gene family or pathway",
      "state": "REGISTERED_SPLIT_DATA_NOT_EXECUTED"
    },
    {
      "level": "G3",
      "task": "Unseen donor",
      "state": "REGISTERED_DONOR_RESOLVED_TRUTH_MISSING"
    },
    {
      "level": "G4",
      "task": "Unseen cell type or differentiation state",
      "state": "REGISTERED_MATCHED_TRUTH_MISSING"
    },
    {
      "level": "G5",
      "task": "Unseen dataset or laboratory",
      "state": "REGISTERED_HARMONIZED_TRUTH_MISSING"
    },
    {
      "level": "G6",
      "task": "Unseen disease background",
      "state": "REGISTERED_DMD_PERTURBATION_TRUTH_MISSING"
    },
    {
      "level": "G7",
      "task": "Unseen modality or combination",
      "state": "REGISTERED_OBSERVED_DOUBLE_TRUTH_MISSING"
    }
  ],
  "baseline_zoo": [
    {
      "baseline_id": "zero_change",
      "state": "IMPLEMENTED_NATIVE"
    },
    {
      "baseline_id": "training_response_mean",
      "state": "IMPLEMENTED_NATIVE"
    },
    {
      "baseline_id": "ridge_residual",
      "state": "IMPLEMENTED_NATIVE"
    },
    {
      "baseline_id": "nearest_neighbour_transfer",
      "state": "REGISTERED_NOT_IMPLEMENTED"
    },
    {
      "baseline_id": "pathway_module_mean",
      "state": "REGISTERED_NOT_IMPLEMENTED"
    },
    {
      "baseline_id": "similarity_weighted_pseudobulk_transfer",
      "state": "REGISTERED_NOT_IMPLEMENTED"
    },
    {
      "baseline_id": "additive_double_perturbation",
      "state": "IMPLEMENTED_NULL_PREVIEW_NO_OBSERVED_DOUBLE"
    }
  ],
  "model_system": {
    "architecture_state": "REGISTERED_NOT_TRAINED",
    "shared_encoder": "context cell-set encoder",
    "perturbation_encoder": "gene identity + protein representation + knowledge-graph features + modality/dose/time",
    "heads": [
      "deterministic pseudobulk residual head",
      "generative population-distribution head"
    ],
    "experts": [
      "ridge residual",
      "summary transfer",
      "context-set model",
      "knowledge-graph residual",
      "flow or diffusion population model"
    ],
    "uncertainty_outputs": [
      "aleatoric uncertainty",
      "epistemic uncertainty",
      "context OOD",
      "perturbation OOD",
      "model disagreement",
      "prediction interval",
      "abstention"
    ]
  },
  "leaderboards": [
    {
      "board": "official_vcc_style",
      "metrics": [
        "DES",
        "PDS",
        "MAE"
      ],
      "state": "PARTIAL_AGGREGATE_ADAPTER_DES_LOCKED"
    },
    {
      "board": "generalist",
      "metrics": [
        "DES",
        "PDS",
        "MAE",
        "delta Pearson",
        "logFC Spearman",
        "DEG AUPRC",
        "effect-size Spearman"
      ],
      "state": "PARTIAL_AGGREGATE_ADAPTER"
    },
    {
      "board": "robustness",
      "metrics": [
        "G1–G7",
        "calibration",
        "interval coverage",
        "abstention risk",
        "worst-decile performance",
        "per-pathway performance",
        "donor fairness",
        "compute and memory"
      ],
      "state": "REGISTERED_DATA_MISSING"
    },
    {
      "board": "dmd_biological",
      "metrics": [
        "fusion",
        "myotube morphology",
        "membrane integrity",
        "calcium",
        "viability",
        "donor replication",
        "reagent replication",
        "disease-specific interaction"
      ],
      "state": "REGISTERED_NO_DMD_OUTCOMES"
    }
  ],
  "error_archetypes": [
    "common_response_collapse",
    "wrong_perturbation_identity",
    "correct_direction_wrong_magnitude",
    "correct_mean_wrong_distribution",
    "donor_failure",
    "state_failure",
    "toxicity_miss",
    "ood_overconfidence"
  ],
  "task_adapter": {
    "input_schema": null,
    "output_schema": null,
    "cell_scale": null,
    "gene_universe": null,
    "task_splits": null,
    "metric_weights": null,
    "submission_format": null,
    "binding_state": "WAITING_FOR_OFFICIAL_TASK_SPECIFICATION"
  },
  "cell_eval": {
    "target_pin": "0.8.2",
    "current_execution": "INTERNAL_FORMULA_ALIGNED_AGGREGATE_ADAPTER_NOT_OFFICIAL_ANNData_SUITE",
    "golden_tests_required": true
  },
  "boundary": "Registered tasks and model architecture are not benchmark results. Missing donor, state, disease and cell-distribution truth remains null and locked."
}