{"H19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H19","identifiers":{"aliases":["D11S813E","ASM","ASM1","NCRNA00008","LINC00008","MIR675HG","GMRSP"],"approved_symbol":"H19","ensembl_gene_id":"ENSG00000130600","hgnc_id":"HGNC:4713","ncbi_gene_id":283120,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/H19","release_manifest":"api/v1.1/release_manifest.json"}},"H1FX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H1FX","identifiers":{"approved_symbol":"H1FX","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/H1FX","release_manifest":"api/v1.1/release_manifest.json"}},"H2AFJ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H2AFJ","identifiers":{"approved_symbol":"H2AFJ","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/H2AFJ","release_manifest":"api/v1.1/release_manifest.json"}},"H2AFX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H2AFX","identifiers":{"approved_symbol":"H2AFX","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/H2AFX","release_manifest":"api/v1.1/release_manifest.json"}},"H2AFY":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H2AFY","identifiers":{"approved_symbol":"H2AFY","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/H2AFY","release_manifest":"api/v1.1/release_manifest.json"}},"H2AFY2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H2AFY2","identifiers":{"approved_symbol":"H2AFY2","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/H2AFY2","release_manifest":"api/v1.1/release_manifest.json"}},"H2AFZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H2AFZ","identifiers":{"approved_symbol":"H2AFZ","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/H2AFZ","release_manifest":"api/v1.1/release_manifest.json"}},"H6PD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"H6PD","identifiers":{"aliases":["H6PDH"],"approved_symbol":"H6PD","ensembl_gene_id":"ENSG00000049239","hgnc_id":"HGNC:4795","ncbi_gene_id":9563,"previous_symbols":["GDH"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/H6PD","release_manifest":"api/v1.1/release_manifest.json"}},"HAAO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAAO","identifiers":{"aliases":["3-HAO","HAO"],"approved_symbol":"HAAO","ensembl_gene_id":"ENSG00000162882","hgnc_id":"HGNC:4796","ncbi_gene_id":23498,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAAO","release_manifest":"api/v1.1/release_manifest.json"}},"HABP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HABP2","identifiers":{"aliases":["HABP","PHBP","HGFAL","FSAP"],"approved_symbol":"HABP2","ensembl_gene_id":"ENSG00000148702","hgnc_id":"HGNC:4798","ncbi_gene_id":3026,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HABP2","release_manifest":"api/v1.1/release_manifest.json"}},"HABP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HABP4","identifiers":{"aliases":["IHABP4","SERBP1L"],"approved_symbol":"HABP4","ensembl_gene_id":"ENSG00000130956","hgnc_id":"HGNC:17062","ncbi_gene_id":22927,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HABP4","release_manifest":"api/v1.1/release_manifest.json"}},"HACD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HACD1","identifiers":{"aliases":["CAP"],"approved_symbol":"HACD1","ensembl_gene_id":"ENSG00000165996","hgnc_id":"HGNC:9639","ncbi_gene_id":9200,"previous_symbols":["PTPLA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HACD1","release_manifest":"api/v1.1/release_manifest.json"}},"HACD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HACD2","identifiers":{"aliases":[],"approved_symbol":"HACD2","ensembl_gene_id":"ENSG00000206527","hgnc_id":"HGNC:9640","ncbi_gene_id":201562,"previous_symbols":["PTPLB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HACD2","release_manifest":"api/v1.1/release_manifest.json"}},"HACD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HACD3","identifiers":{"aliases":["B-ind1","HSPC121"],"approved_symbol":"HACD3","ensembl_gene_id":"ENSG00000074696","hgnc_id":"HGNC:24175","ncbi_gene_id":51495,"previous_symbols":["PTPLAD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HACD3","release_manifest":"api/v1.1/release_manifest.json"}},"HACD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HACD4","identifiers":{"aliases":["Em:AL662879.1","OTTHUMG00000021016"],"approved_symbol":"HACD4","ensembl_gene_id":"ENSG00000188921","hgnc_id":"HGNC:20920","ncbi_gene_id":401494,"previous_symbols":["PTPLAD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HACD4","release_manifest":"api/v1.1/release_manifest.json"}},"HACE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HACE1","identifiers":{"aliases":["KIAA1320"],"approved_symbol":"HACE1","ensembl_gene_id":"ENSG00000085382","hgnc_id":"HGNC:21033","ncbi_gene_id":57531,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HACE1","release_manifest":"api/v1.1/release_manifest.json"}},"HACL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HACL1","identifiers":{"aliases":["2-HPCL","PHYH2"],"approved_symbol":"HACL1","ensembl_gene_id":"ENSG00000131373","hgnc_id":"HGNC:17856","ncbi_gene_id":26061,"previous_symbols":["HPCL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HACL1","release_manifest":"api/v1.1/release_manifest.json"}},"HADH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HADH","identifiers":{"aliases":["HADH1","SCHAD"],"approved_symbol":"HADH","ensembl_gene_id":"ENSG00000138796","hgnc_id":"HGNC:4799","ncbi_gene_id":3033,"previous_symbols":["HADHSC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HADH","release_manifest":"api/v1.1/release_manifest.json"}},"HADHA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HADHA","identifiers":{"aliases":["GBP","LCEH","LCHAD","MTPA"],"approved_symbol":"HADHA","ensembl_gene_id":"ENSG00000084754","hgnc_id":"HGNC:4801","ncbi_gene_id":3030,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HADHA","release_manifest":"api/v1.1/release_manifest.json"}},"HADHB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HADHB","identifiers":{"aliases":["MTPB"],"approved_symbol":"HADHB","ensembl_gene_id":"ENSG00000138029","hgnc_id":"HGNC:4803","ncbi_gene_id":3032,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HADHB","release_manifest":"api/v1.1/release_manifest.json"}},"HAGH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAGH","identifiers":{"aliases":["GLO2","GLXII","HAGH1"],"approved_symbol":"HAGH","ensembl_gene_id":"ENSG00000063854","hgnc_id":"HGNC:4805","ncbi_gene_id":3029,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAGH","release_manifest":"api/v1.1/release_manifest.json"}},"HAGHL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAGHL","identifiers":{"aliases":["MGC2605"],"approved_symbol":"HAGHL","ensembl_gene_id":"ENSG00000103253","hgnc_id":"HGNC:14177","ncbi_gene_id":84264,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAGHL","release_manifest":"api/v1.1/release_manifest.json"}},"HAGLR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAGLR","identifiers":{"aliases":["Mdgt","MIR7704HG","STEEL"],"approved_symbol":"HAGLR","ensembl_gene_id":"ENSG00000224189","hgnc_id":"HGNC:43755","ncbi_gene_id":401022,"previous_symbols":["HOXD-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HAGLR","release_manifest":"api/v1.1/release_manifest.json"}},"HAGLROS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAGLROS","identifiers":{"aliases":[],"approved_symbol":"HAGLROS","ensembl_gene_id":"ENSG00000226363","hgnc_id":"HGNC:50646","ncbi_gene_id":102800310,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HAGLROS","release_manifest":"api/v1.1/release_manifest.json"}},"HAL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAL","identifiers":{"aliases":[],"approved_symbol":"HAL","ensembl_gene_id":"ENSG00000084110","hgnc_id":"HGNC:4806","ncbi_gene_id":3034,"previous_symbols":["HIS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAL","release_manifest":"api/v1.1/release_manifest.json"}},"HAMP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAMP","identifiers":{"aliases":["LEAP-1","HEPC","HFE2B","LEAP1"],"approved_symbol":"HAMP","ensembl_gene_id":"ENSG00000105697","hgnc_id":"HGNC:15598","ncbi_gene_id":57817,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAMP","release_manifest":"api/v1.1/release_manifest.json"}},"HAND2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAND2","identifiers":{"aliases":["dHand","Thing2","Hed","bHLHa26"],"approved_symbol":"HAND2","ensembl_gene_id":"ENSG00000164107","hgnc_id":"HGNC:4808","ncbi_gene_id":9464,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HAND2","release_manifest":"api/v1.1/release_manifest.json"}},"HAO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAO1","identifiers":{"aliases":["GOX"],"approved_symbol":"HAO1","ensembl_gene_id":"ENSG00000101323","hgnc_id":"HGNC:4809","ncbi_gene_id":54363,"previous_symbols":["GOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HAO1","release_manifest":"api/v1.1/release_manifest.json"}},"HAPLN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAPLN1","identifiers":{"aliases":[],"approved_symbol":"HAPLN1","ensembl_gene_id":"ENSG00000145681","hgnc_id":"HGNC:2380","ncbi_gene_id":1404,"previous_symbols":["CRTL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HAPLN1","release_manifest":"api/v1.1/release_manifest.json"}},"HAPLN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAPLN2","identifiers":{"aliases":["BRAL1"],"approved_symbol":"HAPLN2","ensembl_gene_id":"ENSG00000132702","hgnc_id":"HGNC:17410","ncbi_gene_id":60484,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HAPLN2","release_manifest":"api/v1.1/release_manifest.json"}},"HAPLN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAPLN3","identifiers":{"aliases":["HsT19883"],"approved_symbol":"HAPLN3","ensembl_gene_id":"ENSG00000140511","hgnc_id":"HGNC:21446","ncbi_gene_id":145864,"previous_symbols":["EXLD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAPLN3","release_manifest":"api/v1.1/release_manifest.json"}},"HAR1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAR1A","identifiers":{"aliases":["HAR1F","NCRNA00064","LINC00064"],"approved_symbol":"HAR1A","ensembl_gene_id":"ENSG00000225978","hgnc_id":"HGNC:33117","ncbi_gene_id":768096,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAR1A","release_manifest":"api/v1.1/release_manifest.json"}},"HAR1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAR1B","identifiers":{"aliases":["HAR1R","NCRNA00065","LINC00065"],"approved_symbol":"HAR1B","ensembl_gene_id":"ENSG00000231133","hgnc_id":"HGNC:33118","ncbi_gene_id":768097,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HAR1B","release_manifest":"api/v1.1/release_manifest.json"}},"HARBI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HARBI1","identifiers":{"aliases":["FLJ32675"],"approved_symbol":"HARBI1","ensembl_gene_id":"ENSG00000180423","hgnc_id":"HGNC:26522","ncbi_gene_id":283254,"previous_symbols":["C11orf77"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HARBI1","release_manifest":"api/v1.1/release_manifest.json"}},"HARS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HARS","identifiers":{"approved_symbol":"HARS","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HARS","release_manifest":"api/v1.1/release_manifest.json"}},"HARS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HARS2","identifiers":{"aliases":["HO3","HARSR"],"approved_symbol":"HARS2","ensembl_gene_id":"ENSG00000112855","hgnc_id":"HGNC:4817","ncbi_gene_id":23438,"previous_symbols":["HARSL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HARS2","release_manifest":"api/v1.1/release_manifest.json"}},"HAS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAS1","identifiers":{"aliases":[],"approved_symbol":"HAS1","ensembl_gene_id":"ENSG00000105509","hgnc_id":"HGNC:4818","ncbi_gene_id":3036,"previous_symbols":["HAS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HAS1","release_manifest":"api/v1.1/release_manifest.json"}},"HAS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAS2","identifiers":{"aliases":[],"approved_symbol":"HAS2","ensembl_gene_id":"ENSG00000170961","hgnc_id":"HGNC:4819","ncbi_gene_id":3037,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAS2","release_manifest":"api/v1.1/release_manifest.json"}},"HAS2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAS2-AS1","identifiers":{"aliases":["HASNT","NCRNA00077"],"approved_symbol":"HAS2-AS1","ensembl_gene_id":"ENSG00000248690","hgnc_id":"HGNC:34340","ncbi_gene_id":594842,"previous_symbols":["HAS2AS","HAS2-AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HAS2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HAS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAS3","identifiers":{"aliases":[],"approved_symbol":"HAS3","ensembl_gene_id":"ENSG00000103044","hgnc_id":"HGNC:4820","ncbi_gene_id":3038,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAS3","release_manifest":"api/v1.1/release_manifest.json"}},"HASPIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HASPIN","identifiers":{"aliases":[],"approved_symbol":"HASPIN","ensembl_gene_id":"ENSG00000177602","hgnc_id":"HGNC:19682","ncbi_gene_id":83903,"previous_symbols":["GSG2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HASPIN","release_manifest":"api/v1.1/release_manifest.json"}},"HAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAT1","identifiers":{"aliases":["KAT1"],"approved_symbol":"HAT1","ensembl_gene_id":"ENSG00000128708","hgnc_id":"HGNC:4821","ncbi_gene_id":8520,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAT1","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS1","identifiers":{"aliases":["HEI-C","HsT1461","FLJ40084"],"approved_symbol":"HAUS1","ensembl_gene_id":"ENSG00000152240","hgnc_id":"HGNC:25174","ncbi_gene_id":115106,"previous_symbols":["CCDC5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS1","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS2","identifiers":{"aliases":["FLJ10460","HsT17025"],"approved_symbol":"HAUS2","ensembl_gene_id":"ENSG00000137814","hgnc_id":"HGNC:25530","ncbi_gene_id":55142,"previous_symbols":["C15orf25","CEP27"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS2","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS3","identifiers":{"aliases":["MGC4701","IT1","dgt3"],"approved_symbol":"HAUS3","ensembl_gene_id":"ENSG00000214367","hgnc_id":"HGNC:28719","ncbi_gene_id":79441,"previous_symbols":["C4orf15"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS3","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS4","identifiers":{"aliases":["FLJ20424"],"approved_symbol":"HAUS4","ensembl_gene_id":"ENSG00000092036","hgnc_id":"HGNC:20163","ncbi_gene_id":54930,"previous_symbols":["C14orf94"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS4","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS5","identifiers":{"aliases":["dgt5"],"approved_symbol":"HAUS5","ensembl_gene_id":"ENSG00000249115","hgnc_id":"HGNC:29130","ncbi_gene_id":23354,"previous_symbols":["KIAA0841"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS5","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS6","identifiers":{"aliases":["FLJ20060","KIAA1574","dgt6"],"approved_symbol":"HAUS6","ensembl_gene_id":"ENSG00000147874","hgnc_id":"HGNC:25948","ncbi_gene_id":54801,"previous_symbols":["FAM29A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS6","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS7","identifiers":{"aliases":["UIP1"],"approved_symbol":"HAUS7","ensembl_gene_id":"ENSG00000213397","hgnc_id":"HGNC:32979","ncbi_gene_id":55559,"previous_symbols":["UCHL5IP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAUS7","release_manifest":"api/v1.1/release_manifest.json"}},"HAUS8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAUS8","identifiers":{"aliases":["MGC20533","NY-SAR-48"],"approved_symbol":"HAUS8","ensembl_gene_id":"ENSG00000131351","hgnc_id":"HGNC:30532","ncbi_gene_id":93323,"previous_symbols":["HICE1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HAUS8","release_manifest":"api/v1.1/release_manifest.json"}},"HAVCR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAVCR1","identifiers":{"aliases":["HAVCR-1","TIM-1","TIM1","HAVCR","TIMD1","CD365","KIM1"],"approved_symbol":"HAVCR1","ensembl_gene_id":"ENSG00000113249","hgnc_id":"HGNC:17866","ncbi_gene_id":26762,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAVCR1","release_manifest":"api/v1.1/release_manifest.json"}},"HAVCR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAVCR2","identifiers":{"aliases":["Tim-3","TIM3","FLJ14428","TIMD3","CD366"],"approved_symbol":"HAVCR2","ensembl_gene_id":"ENSG00000135077","hgnc_id":"HGNC:18437","ncbi_gene_id":84868,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAVCR2","release_manifest":"api/v1.1/release_manifest.json"}},"HAX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HAX1","identifiers":{"aliases":["HS1BP1","HCLSBP1","HAX-1"],"approved_symbol":"HAX1","ensembl_gene_id":"ENSG00000143575","hgnc_id":"HGNC:16915","ncbi_gene_id":10456,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HAX1","release_manifest":"api/v1.1/release_manifest.json"}},"HBA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBA1","identifiers":{"aliases":["HBA-T3"],"approved_symbol":"HBA1","ensembl_gene_id":"ENSG00000206172","hgnc_id":"HGNC:4823","ncbi_gene_id":3039,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HBA1","release_manifest":"api/v1.1/release_manifest.json"}},"HBA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBA2","identifiers":{"aliases":["HBA-T2"],"approved_symbol":"HBA2","ensembl_gene_id":"ENSG00000188536","hgnc_id":"HGNC:4824","ncbi_gene_id":3040,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HBA2","release_manifest":"api/v1.1/release_manifest.json"}},"HBB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBB","identifiers":{"aliases":["CD113t-C","beta-globin"],"approved_symbol":"HBB","ensembl_gene_id":"ENSG00000244734","hgnc_id":"HGNC:4827","ncbi_gene_id":3043,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HBB","release_manifest":"api/v1.1/release_manifest.json"}},"HBEGF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBEGF","identifiers":{"aliases":["HB-EGF"],"approved_symbol":"HBEGF","ensembl_gene_id":"ENSG00000113070","hgnc_id":"HGNC:3059","ncbi_gene_id":1839,"previous_symbols":["HEGFL","DTS","DTR"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HBEGF","release_manifest":"api/v1.1/release_manifest.json"}},"HBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBP1","identifiers":{"aliases":[],"approved_symbol":"HBP1","ensembl_gene_id":"ENSG00000105856","hgnc_id":"HGNC:23200","ncbi_gene_id":26959,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HBP1","release_manifest":"api/v1.1/release_manifest.json"}},"HBQ1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBQ1","identifiers":{"aliases":["HBQ"],"approved_symbol":"HBQ1","ensembl_gene_id":"ENSG00000086506","hgnc_id":"HGNC:4833","ncbi_gene_id":3049,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HBQ1","release_manifest":"api/v1.1/release_manifest.json"}},"HBS1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBS1L","identifiers":{"aliases":["ERFS","HBS1","HSPC276","KIAA1038","DKFZp434g247","EF-1a","eRF3c"],"approved_symbol":"HBS1L","ensembl_gene_id":"ENSG00000112339","hgnc_id":"HGNC:4834","ncbi_gene_id":10767,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HBS1L","release_manifest":"api/v1.1/release_manifest.json"}},"HBZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HBZ","identifiers":{"aliases":["HBZ1","HBZ-T1"],"approved_symbol":"HBZ","ensembl_gene_id":"ENSG00000130656","hgnc_id":"HGNC:4835","ncbi_gene_id":3050,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HBZ","release_manifest":"api/v1.1/release_manifest.json"}},"HCAR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCAR1","identifiers":{"aliases":["HCA1","FKSG80","TA-GPCR","LACR1"],"approved_symbol":"HCAR1","ensembl_gene_id":"ENSG00000196917","hgnc_id":"HGNC:4532","ncbi_gene_id":27198,"previous_symbols":["GPR104","GPR81"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HCAR1","release_manifest":"api/v1.1/release_manifest.json"}},"HCAR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCAR2","identifiers":{"aliases":["HCA2","HM74A","PUMAG","Puma-g","NIACR1"],"approved_symbol":"HCAR2","ensembl_gene_id":"ENSG00000182782","hgnc_id":"HGNC:24827","ncbi_gene_id":338442,"previous_symbols":["GPR109A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCAR2","release_manifest":"api/v1.1/release_manifest.json"}},"HCAR3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCAR3","identifiers":{"aliases":["HCA3","HM74"],"approved_symbol":"HCAR3","ensembl_gene_id":"ENSG00000255398","hgnc_id":"HGNC:16824","ncbi_gene_id":8843,"previous_symbols":["GPR109B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HCAR3","release_manifest":"api/v1.1/release_manifest.json"}},"HCCS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCCS","identifiers":{"aliases":["CCHL"],"approved_symbol":"HCCS","ensembl_gene_id":"ENSG00000004961","hgnc_id":"HGNC:4837","ncbi_gene_id":3052,"previous_symbols":["MLS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCCS","release_manifest":"api/v1.1/release_manifest.json"}},"HCFC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCFC1","identifiers":{"aliases":["HCF-1","HCF1","CFF","VCAF","MGC70925","PPP1R89"],"approved_symbol":"HCFC1","ensembl_gene_id":"ENSG00000172534","hgnc_id":"HGNC:4839","ncbi_gene_id":3054,"previous_symbols":["HFC1","MRX3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCFC1","release_manifest":"api/v1.1/release_manifest.json"}},"HCFC1R1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCFC1R1","identifiers":{"aliases":["HPIP","FLJ20568"],"approved_symbol":"HCFC1R1","ensembl_gene_id":"ENSG00000103145","hgnc_id":"HGNC:21198","ncbi_gene_id":54985,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCFC1R1","release_manifest":"api/v1.1/release_manifest.json"}},"HCFC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCFC2","identifiers":{"aliases":["HCF-2"],"approved_symbol":"HCFC2","ensembl_gene_id":"ENSG00000111727","hgnc_id":"HGNC:24972","ncbi_gene_id":29915,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCFC2","release_manifest":"api/v1.1/release_manifest.json"}},"HCG11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG11","identifiers":{"aliases":["bK14H9.3","FLJ14049","FLJ30357"],"approved_symbol":"HCG11","ensembl_gene_id":"ENSG00000228223","hgnc_id":"HGNC:17707","ncbi_gene_id":493812,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCG11","release_manifest":"api/v1.1/release_manifest.json"}},"HCG17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG17","identifiers":{"approved_symbol":"HCG17","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HCG17","release_manifest":"api/v1.1/release_manifest.json"}},"HCG18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG18","identifiers":{"aliases":["FLJ31598","FLJ25550","Em:AB014087.1"],"approved_symbol":"HCG18","ensembl_gene_id":"ENSG00000231074","hgnc_id":"HGNC:31337","ncbi_gene_id":414777,"previous_symbols":["HCG17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HCG18","release_manifest":"api/v1.1/release_manifest.json"}},"HCG20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG20","identifiers":{"aliases":["AB023051.1","NCRNA00149"],"approved_symbol":"HCG20","ensembl_gene_id":"ENSG00000228022","hgnc_id":"HGNC:31334","ncbi_gene_id":105375013,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCG20","release_manifest":"api/v1.1/release_manifest.json"}},"HCG22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG22","identifiers":{"aliases":["FLJ37114","PBMUCL2"],"approved_symbol":"HCG22","ensembl_gene_id":"ENSG00000228789","hgnc_id":"HGNC:27780","ncbi_gene_id":285834,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCG22","release_manifest":"api/v1.1/release_manifest.json"}},"HCG25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG25","identifiers":{"aliases":["dJ1033B10.16"],"approved_symbol":"HCG25","ensembl_gene_id":"ENSG00000232940","hgnc_id":"HGNC:20196","ncbi_gene_id":414765,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCG25","release_manifest":"api/v1.1/release_manifest.json"}},"HCG27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG27","identifiers":{"aliases":["bPG299F13.9","bCX101P6.9","bQB115I13.2","FLJ40123"],"approved_symbol":"HCG27","ensembl_gene_id":"ENSG00000206344","hgnc_id":"HGNC:27366","ncbi_gene_id":253018,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCG27","release_manifest":"api/v1.1/release_manifest.json"}},"HCG9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCG9","identifiers":{"aliases":["PERB11","HCGIX","HCGIX4","HCGIX-4"],"approved_symbol":"HCG9","ensembl_gene_id":"ENSG00000204625","hgnc_id":"HGNC:21243","ncbi_gene_id":10255,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCG9","release_manifest":"api/v1.1/release_manifest.json"}},"HCK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCK","identifiers":{"aliases":["JTK9"],"approved_symbol":"HCK","ensembl_gene_id":"ENSG00000101336","hgnc_id":"HGNC:4840","ncbi_gene_id":3055,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HCK","release_manifest":"api/v1.1/release_manifest.json"}},"HCLS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCLS1","identifiers":{"aliases":["HS1","CTTNL"],"approved_symbol":"HCLS1","ensembl_gene_id":"ENSG00000180353","hgnc_id":"HGNC:4844","ncbi_gene_id":3059,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HCLS1","release_manifest":"api/v1.1/release_manifest.json"}},"HCN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCN1","identifiers":{"aliases":["BCNG-1","HAC-2"],"approved_symbol":"HCN1","ensembl_gene_id":"ENSG00000164588","hgnc_id":"HGNC:4845","ncbi_gene_id":348980,"previous_symbols":["BCNG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCN1","release_manifest":"api/v1.1/release_manifest.json"}},"HCN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCN2","identifiers":{"aliases":["BCNG-2","HAC-1"],"approved_symbol":"HCN2","ensembl_gene_id":"ENSG00000099822","hgnc_id":"HGNC:4846","ncbi_gene_id":610,"previous_symbols":["BCNG2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCN2","release_manifest":"api/v1.1/release_manifest.json"}},"HCN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCN3","identifiers":{"aliases":["KIAA1535"],"approved_symbol":"HCN3","ensembl_gene_id":"ENSG00000143630","hgnc_id":"HGNC:19183","ncbi_gene_id":57657,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCN3","release_manifest":"api/v1.1/release_manifest.json"}},"HCN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCN4","identifiers":{"aliases":[],"approved_symbol":"HCN4","ensembl_gene_id":"ENSG00000138622","hgnc_id":"HGNC:16882","ncbi_gene_id":10021,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HCN4","release_manifest":"api/v1.1/release_manifest.json"}},"HCP5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCP5","identifiers":{"aliases":["D6S2650E","P5-1"],"approved_symbol":"HCP5","ensembl_gene_id":"ENSG00000206337","hgnc_id":"HGNC:21659","ncbi_gene_id":10866,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCP5","release_manifest":"api/v1.1/release_manifest.json"}},"HCRT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCRT","identifiers":{"aliases":["PPOX","OX"],"approved_symbol":"HCRT","ensembl_gene_id":"ENSG00000161610","hgnc_id":"HGNC:4847","ncbi_gene_id":3060,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HCRT","release_manifest":"api/v1.1/release_manifest.json"}},"HCRTR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCRTR1","identifiers":{"aliases":["OX1R","OXR1","ORXR1"],"approved_symbol":"HCRTR1","ensembl_gene_id":"ENSG00000121764","hgnc_id":"HGNC:4848","ncbi_gene_id":3061,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCRTR1","release_manifest":"api/v1.1/release_manifest.json"}},"HCRTR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCRTR2","identifiers":{"aliases":["OX2R","OXR2","ORXR2"],"approved_symbol":"HCRTR2","ensembl_gene_id":"ENSG00000137252","hgnc_id":"HGNC:4849","ncbi_gene_id":3062,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCRTR2","release_manifest":"api/v1.1/release_manifest.json"}},"HCST":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HCST","identifiers":{"aliases":["DAP10","DKFZP586C1522","KAP10"],"approved_symbol":"HCST","ensembl_gene_id":"ENSG00000126264","hgnc_id":"HGNC:16977","ncbi_gene_id":10870,"previous_symbols":["PIK3AP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HCST","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC1","identifiers":{"aliases":["HD1","GON-10","KDAC1"],"approved_symbol":"HDAC1","ensembl_gene_id":"ENSG00000116478","hgnc_id":"HGNC:4852","ncbi_gene_id":3065,"previous_symbols":["RPD3L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC1","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC10","identifiers":{"aliases":["DKFZP761B039"],"approved_symbol":"HDAC10","ensembl_gene_id":"ENSG00000100429","hgnc_id":"HGNC:18128","ncbi_gene_id":83933,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC10","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC11","identifiers":{"aliases":[],"approved_symbol":"HDAC11","ensembl_gene_id":"ENSG00000163517","hgnc_id":"HGNC:19086","ncbi_gene_id":79885,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC11","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC11-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC11-AS1","identifiers":{"aliases":[],"approved_symbol":"HDAC11-AS1","ensembl_gene_id":"ENSG00000244502","hgnc_id":"HGNC:40868","ncbi_gene_id":100874101,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC11-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC2","identifiers":{"aliases":["RPD3","YAF1","KDAC2"],"approved_symbol":"HDAC2","ensembl_gene_id":"ENSG00000196591","hgnc_id":"HGNC:4853","ncbi_gene_id":3066,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC2","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC2-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC2-AS2","identifiers":{"aliases":["ENST00000421891"],"approved_symbol":"HDAC2-AS2","ensembl_gene_id":"ENSG00000228624","hgnc_id":"HGNC:43590","ncbi_gene_id":101927768,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC2-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC3","identifiers":{"aliases":["RPD3","HD3","RPD3-2","KDAC3"],"approved_symbol":"HDAC3","ensembl_gene_id":"ENSG00000171720","hgnc_id":"HGNC:4854","ncbi_gene_id":8841,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HDAC3","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC4","identifiers":{"aliases":["KIAA0288","HDAC-A","HDACA","HD4","HA6116","HDAC-4"],"approved_symbol":"HDAC4","ensembl_gene_id":"ENSG00000068024","hgnc_id":"HGNC:14063","ncbi_gene_id":9759,"previous_symbols":["BDMR"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC4","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC4-AS1","identifiers":{"aliases":[],"approved_symbol":"HDAC4-AS1","ensembl_gene_id":"ENSG00000222020","hgnc_id":"HGNC:54064","ncbi_gene_id":101928111,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC5","identifiers":{"aliases":["KIAA0600","NY-CO-9","FLJ90614"],"approved_symbol":"HDAC5","ensembl_gene_id":"ENSG00000108840","hgnc_id":"HGNC:14068","ncbi_gene_id":10014,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC5","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC6","identifiers":{"aliases":["KIAA0901","JM21","HD6","FLJ16239","PPP1R90","KDAC6"],"approved_symbol":"HDAC6","ensembl_gene_id":"ENSG00000094631","hgnc_id":"HGNC:14064","ncbi_gene_id":10013,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC6","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC7","identifiers":{"aliases":["DKFZP586J0917"],"approved_symbol":"HDAC7","ensembl_gene_id":"ENSG00000061273","hgnc_id":"HGNC:14067","ncbi_gene_id":51564,"previous_symbols":["HDAC7A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC7","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC8","identifiers":{"aliases":["RPD3","KDAC8"],"approved_symbol":"HDAC8","ensembl_gene_id":"ENSG00000147099","hgnc_id":"HGNC:13315","ncbi_gene_id":55869,"previous_symbols":["HDACL1","WTS","MRXS6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC8","release_manifest":"api/v1.1/release_manifest.json"}},"HDAC9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDAC9","identifiers":{"aliases":["KIAA0744","HDAC","MITR","HD7","HDAC7B"],"approved_symbol":"HDAC9","ensembl_gene_id":"ENSG00000048052","hgnc_id":"HGNC:14065","ncbi_gene_id":9734,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDAC9","release_manifest":"api/v1.1/release_manifest.json"}},"HDDC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDDC2","identifiers":{"aliases":["CGI-130","dJ167O5.2"],"approved_symbol":"HDDC2","ensembl_gene_id":"ENSG00000111906","hgnc_id":"HGNC:21078","ncbi_gene_id":51020,"previous_symbols":["C6orf74"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDDC2","release_manifest":"api/v1.1/release_manifest.json"}},"HDDC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDDC3","identifiers":{"aliases":["MGC45386","MESH1","MYNRL15"],"approved_symbol":"HDDC3","ensembl_gene_id":"ENSG00000184508","hgnc_id":"HGNC:30522","ncbi_gene_id":374659,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDDC3","release_manifest":"api/v1.1/release_manifest.json"}},"HDGF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDGF","identifiers":{"aliases":["HMG1L2"],"approved_symbol":"HDGF","ensembl_gene_id":"ENSG00000143321","hgnc_id":"HGNC:4856","ncbi_gene_id":3068,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HDGF","release_manifest":"api/v1.1/release_manifest.json"}},"HDGFL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDGFL2","identifiers":{"aliases":["HRP2","Hdgfrp2"],"approved_symbol":"HDGFL2","ensembl_gene_id":"ENSG00000167674","hgnc_id":"HGNC:14680","ncbi_gene_id":84717,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDGFL2","release_manifest":"api/v1.1/release_manifest.json"}},"HDGFL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDGFL3","identifiers":{"aliases":["HRP-3","Hdgfrp3"],"approved_symbol":"HDGFL3","ensembl_gene_id":"ENSG00000166503","hgnc_id":"HGNC:24937","ncbi_gene_id":50810,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDGFL3","release_manifest":"api/v1.1/release_manifest.json"}},"HDHD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDHD2","identifiers":{"aliases":["DKFZP564D1378"],"approved_symbol":"HDHD2","ensembl_gene_id":"ENSG00000167220","hgnc_id":"HGNC:25364","ncbi_gene_id":84064,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDHD2","release_manifest":"api/v1.1/release_manifest.json"}},"HDHD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDHD3","identifiers":{"aliases":["MGC12904"],"approved_symbol":"HDHD3","ensembl_gene_id":"ENSG00000119431","hgnc_id":"HGNC:28171","ncbi_gene_id":81932,"previous_symbols":["C9orf158"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDHD3","release_manifest":"api/v1.1/release_manifest.json"}},"HDHD5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDHD5","identifiers":{"aliases":[],"approved_symbol":"HDHD5","ensembl_gene_id":"ENSG00000069998","hgnc_id":"HGNC:1843","ncbi_gene_id":27440,"previous_symbols":["CECR5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDHD5","release_manifest":"api/v1.1/release_manifest.json"}},"HDHD5-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDHD5-AS1","identifiers":{"aliases":["NCRNA00017"],"approved_symbol":"HDHD5-AS1","ensembl_gene_id":"ENSG00000185837","hgnc_id":"HGNC:1842","ncbi_gene_id":100130717,"previous_symbols":["CECR4","CECR5-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDHD5-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HDLBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDLBP","identifiers":{"aliases":["HBP"],"approved_symbol":"HDLBP","ensembl_gene_id":"ENSG00000115677","hgnc_id":"HGNC:4857","ncbi_gene_id":3069,"previous_symbols":["VGL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDLBP","release_manifest":"api/v1.1/release_manifest.json"}},"HDX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HDX","identifiers":{"aliases":["FLJ30678"],"approved_symbol":"HDX","ensembl_gene_id":"ENSG00000165259","hgnc_id":"HGNC:26411","ncbi_gene_id":139324,"previous_symbols":["CXorf43"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HDX","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR1","identifiers":{"aliases":["FLJ10359","BAP28","UTP10"],"approved_symbol":"HEATR1","ensembl_gene_id":"ENSG00000119285","hgnc_id":"HGNC:25517","ncbi_gene_id":55127,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEATR1","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR3","identifiers":{"aliases":["FLJ20718"],"approved_symbol":"HEATR3","ensembl_gene_id":"ENSG00000155393","hgnc_id":"HGNC:26087","ncbi_gene_id":55027,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEATR3","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR4","identifiers":{"aliases":["MGC48595"],"approved_symbol":"HEATR4","ensembl_gene_id":"ENSG00000187105","hgnc_id":"HGNC:16761","ncbi_gene_id":399671,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEATR4","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR5A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR5A","identifiers":{"aliases":["DKFZP434I1735","p200b"],"approved_symbol":"HEATR5A","ensembl_gene_id":"ENSG00000129493","hgnc_id":"HGNC:20276","ncbi_gene_id":25938,"previous_symbols":["C14orf125"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEATR5A","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR5B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR5B","identifiers":{"aliases":["KIAA1414","DKFZp686P15184","p200","p200a"],"approved_symbol":"HEATR5B","ensembl_gene_id":"ENSG00000008869","hgnc_id":"HGNC:29273","ncbi_gene_id":54497,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEATR5B","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR6","identifiers":{"aliases":["ABC1","FLJ22087"],"approved_symbol":"HEATR6","ensembl_gene_id":"ENSG00000068097","hgnc_id":"HGNC:24076","ncbi_gene_id":63897,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEATR6","release_manifest":"api/v1.1/release_manifest.json"}},"HEATR9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEATR9","identifiers":{"aliases":["FLJ32830"],"approved_symbol":"HEATR9","ensembl_gene_id":"ENSG00000270379","hgnc_id":"HGNC:26548","ncbi_gene_id":256957,"previous_symbols":["C17orf66"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HEATR9","release_manifest":"api/v1.1/release_manifest.json"}},"HEBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEBP1","identifiers":{"aliases":["HEBP","HBP"],"approved_symbol":"HEBP1","ensembl_gene_id":"ENSG00000013583","hgnc_id":"HGNC:17176","ncbi_gene_id":50865,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEBP1","release_manifest":"api/v1.1/release_manifest.json"}},"HEBP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEBP2","identifiers":{"aliases":["SOUL"],"approved_symbol":"HEBP2","ensembl_gene_id":"ENSG00000051620","hgnc_id":"HGNC:15716","ncbi_gene_id":23593,"previous_symbols":["C6orf34"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEBP2","release_manifest":"api/v1.1/release_manifest.json"}},"HECA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECA","identifiers":{"aliases":["HDCL","hHDC","HDC","dJ225E12.1"],"approved_symbol":"HECA","ensembl_gene_id":"ENSG00000112406","hgnc_id":"HGNC:21041","ncbi_gene_id":51696,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECA","release_manifest":"api/v1.1/release_manifest.json"}},"HECTD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECTD1","identifiers":{"aliases":["KIAA1131"],"approved_symbol":"HECTD1","ensembl_gene_id":"ENSG00000092148","hgnc_id":"HGNC:20157","ncbi_gene_id":25831,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECTD1","release_manifest":"api/v1.1/release_manifest.json"}},"HECTD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECTD2","identifiers":{"aliases":["FLJ37306"],"approved_symbol":"HECTD2","ensembl_gene_id":"ENSG00000165338","hgnc_id":"HGNC:26736","ncbi_gene_id":143279,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECTD2","release_manifest":"api/v1.1/release_manifest.json"}},"HECTD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECTD3","identifiers":{"aliases":["FLJ21156"],"approved_symbol":"HECTD3","ensembl_gene_id":"ENSG00000126107","hgnc_id":"HGNC:26117","ncbi_gene_id":79654,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECTD3","release_manifest":"api/v1.1/release_manifest.json"}},"HECTD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECTD4","identifiers":{"aliases":["FLJ34154","KIAA0614"],"approved_symbol":"HECTD4","ensembl_gene_id":"ENSG00000173064","hgnc_id":"HGNC:26611","ncbi_gene_id":283450,"previous_symbols":["C12orf51"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECTD4","release_manifest":"api/v1.1/release_manifest.json"}},"HECW1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECW1","identifiers":{"aliases":["KIAA0322","NEDL1"],"approved_symbol":"HECW1","ensembl_gene_id":"ENSG00000002746","hgnc_id":"HGNC:22195","ncbi_gene_id":23072,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECW1","release_manifest":"api/v1.1/release_manifest.json"}},"HECW2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HECW2","identifiers":{"aliases":["KIAA1301","NEDL2"],"approved_symbol":"HECW2","ensembl_gene_id":"ENSG00000138411","hgnc_id":"HGNC:29853","ncbi_gene_id":57520,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HECW2","release_manifest":"api/v1.1/release_manifest.json"}},"HEG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEG1","identifiers":{"aliases":["KIAA1237","HEG"],"approved_symbol":"HEG1","ensembl_gene_id":"ENSG00000173706","hgnc_id":"HGNC:29227","ncbi_gene_id":57493,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEG1","release_manifest":"api/v1.1/release_manifest.json"}},"HEIH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEIH","identifiers":{"aliases":["LINC-HEIH","lncRNA-HEIH","LINC00848","HCCAT2"],"approved_symbol":"HEIH","ensembl_gene_id":"ENSG00000278970","hgnc_id":"HGNC:45049","ncbi_gene_id":100859930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HEIH","release_manifest":"api/v1.1/release_manifest.json"}},"HELB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HELB","identifiers":{"aliases":[],"approved_symbol":"HELB","ensembl_gene_id":"ENSG00000127311","hgnc_id":"HGNC:17196","ncbi_gene_id":92797,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HELB","release_manifest":"api/v1.1/release_manifest.json"}},"HELLPAR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HELLPAR","identifiers":{"aliases":["LINC-HELLP"],"approved_symbol":"HELLPAR","ensembl_gene_id":"ENSG00000281344","hgnc_id":"HGNC:43984","ncbi_gene_id":101101692,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HELLPAR","release_manifest":"api/v1.1/release_manifest.json"}},"HELLS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HELLS","identifiers":{"aliases":["PASG","SMARCA6","LSH","Nbla10143","SALNR"],"approved_symbol":"HELLS","ensembl_gene_id":"ENSG00000119969","hgnc_id":"HGNC:4861","ncbi_gene_id":3070,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HELLS","release_manifest":"api/v1.1/release_manifest.json"}},"HELQ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HELQ","identifiers":{"aliases":["Hel308"],"approved_symbol":"HELQ","ensembl_gene_id":"ENSG00000163312","hgnc_id":"HGNC:18536","ncbi_gene_id":113510,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HELQ","release_manifest":"api/v1.1/release_manifest.json"}},"HELZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HELZ","identifiers":{"aliases":["KIAA0054","HUMORF5","DHRC"],"approved_symbol":"HELZ","ensembl_gene_id":"ENSG00000198265","hgnc_id":"HGNC:16878","ncbi_gene_id":9931,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HELZ","release_manifest":"api/v1.1/release_manifest.json"}},"HELZ2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HELZ2","identifiers":{"aliases":["PDIP1","PRIC285","KIAA1769"],"approved_symbol":"HELZ2","ensembl_gene_id":"ENSG00000130589","hgnc_id":"HGNC:30021","ncbi_gene_id":85441,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HELZ2","release_manifest":"api/v1.1/release_manifest.json"}},"HEMK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEMK1","identifiers":{"aliases":["MTQ1"],"approved_symbol":"HEMK1","ensembl_gene_id":"ENSG00000114735","hgnc_id":"HGNC:24923","ncbi_gene_id":51409,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HEMK1","release_manifest":"api/v1.1/release_manifest.json"}},"HENMT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HENMT1","identifiers":{"aliases":["FLJ30525","HEN1"],"approved_symbol":"HENMT1","ensembl_gene_id":"ENSG00000162639","hgnc_id":"HGNC:26400","ncbi_gene_id":113802,"previous_symbols":["C1orf59"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HENMT1","release_manifest":"api/v1.1/release_manifest.json"}},"HEPACAM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEPACAM2","identifiers":{"aliases":["FLJ38683"],"approved_symbol":"HEPACAM2","ensembl_gene_id":"ENSG00000188175","hgnc_id":"HGNC:27364","ncbi_gene_id":253012,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HEPACAM2","release_manifest":"api/v1.1/release_manifest.json"}},"HEPH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEPH","identifiers":{"aliases":["KIAA0698","CPL"],"approved_symbol":"HEPH","ensembl_gene_id":"ENSG00000089472","hgnc_id":"HGNC:4866","ncbi_gene_id":9843,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEPH","release_manifest":"api/v1.1/release_manifest.json"}},"HEPHL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEPHL1","identifiers":{"aliases":["DKFZp686F22190","Zp"],"approved_symbol":"HEPHL1","ensembl_gene_id":"ENSG00000181333","hgnc_id":"HGNC:30477","ncbi_gene_id":341208,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEPHL1","release_manifest":"api/v1.1/release_manifest.json"}},"HERC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERC1","identifiers":{"aliases":["p532","p619"],"approved_symbol":"HERC1","ensembl_gene_id":"ENSG00000103657","hgnc_id":"HGNC:4867","ncbi_gene_id":8925,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HERC1","release_manifest":"api/v1.1/release_manifest.json"}},"HERC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERC2","identifiers":{"aliases":["jdf2","p528","D15F37S1"],"approved_symbol":"HERC2","ensembl_gene_id":"ENSG00000128731","hgnc_id":"HGNC:4868","ncbi_gene_id":8924,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HERC2","release_manifest":"api/v1.1/release_manifest.json"}},"HERC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERC3","identifiers":{"aliases":["KIAA0032"],"approved_symbol":"HERC3","ensembl_gene_id":"ENSG00000138641","hgnc_id":"HGNC:4876","ncbi_gene_id":8916,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HERC3","release_manifest":"api/v1.1/release_manifest.json"}},"HERC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERC4","identifiers":{"aliases":["DKFZP564G092","KIAA1593"],"approved_symbol":"HERC4","ensembl_gene_id":"ENSG00000148634","hgnc_id":"HGNC:24521","ncbi_gene_id":26091,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HERC4","release_manifest":"api/v1.1/release_manifest.json"}},"HERC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERC5","identifiers":{"aliases":["CEB1"],"approved_symbol":"HERC5","ensembl_gene_id":"ENSG00000138646","hgnc_id":"HGNC:24368","ncbi_gene_id":51191,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HERC5","release_manifest":"api/v1.1/release_manifest.json"}},"HERC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERC6","identifiers":{"aliases":["FLJ20637"],"approved_symbol":"HERC6","ensembl_gene_id":"ENSG00000138642","hgnc_id":"HGNC:26072","ncbi_gene_id":55008,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HERC6","release_manifest":"api/v1.1/release_manifest.json"}},"HERPUD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERPUD1","identifiers":{"aliases":["KIAA0025","Mif1","HERP","SUP"],"approved_symbol":"HERPUD1","ensembl_gene_id":"ENSG00000051108","hgnc_id":"HGNC:13744","ncbi_gene_id":9709,"previous_symbols":["HERPUD1-IT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HERPUD1","release_manifest":"api/v1.1/release_manifest.json"}},"HERPUD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HERPUD2","identifiers":{"aliases":["FLJ22313"],"approved_symbol":"HERPUD2","ensembl_gene_id":"ENSG00000122557","hgnc_id":"HGNC:21915","ncbi_gene_id":64224,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HERPUD2","release_manifest":"api/v1.1/release_manifest.json"}},"HES1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HES1","identifiers":{"aliases":["FLJ20408","HES-1","bHLHb39"],"approved_symbol":"HES1","ensembl_gene_id":"ENSG00000114315","hgnc_id":"HGNC:5192","ncbi_gene_id":3280,"previous_symbols":["HRY"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HES1","release_manifest":"api/v1.1/release_manifest.json"}},"HES4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HES4","identifiers":{"aliases":["bHLHb42"],"approved_symbol":"HES4","ensembl_gene_id":"ENSG00000188290","hgnc_id":"HGNC:24149","ncbi_gene_id":57801,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HES4","release_manifest":"api/v1.1/release_manifest.json"}},"HES5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HES5","identifiers":{"aliases":["bHLHb38"],"approved_symbol":"HES5","ensembl_gene_id":"ENSG00000197921","hgnc_id":"HGNC:19764","ncbi_gene_id":388585,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HES5","release_manifest":"api/v1.1/release_manifest.json"}},"HES6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HES6","identifiers":{"aliases":["bHLHb41"],"approved_symbol":"HES6","ensembl_gene_id":"ENSG00000144485","hgnc_id":"HGNC:18254","ncbi_gene_id":55502,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HES6","release_manifest":"api/v1.1/release_manifest.json"}},"HES7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HES7","identifiers":{"aliases":["bHLHb37"],"approved_symbol":"HES7","ensembl_gene_id":"ENSG00000179111","hgnc_id":"HGNC:15977","ncbi_gene_id":84667,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HES7","release_manifest":"api/v1.1/release_manifest.json"}},"HESX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HESX1","identifiers":{"aliases":["RPX","ANF"],"approved_symbol":"HESX1","ensembl_gene_id":"ENSG00000163666","hgnc_id":"HGNC:4877","ncbi_gene_id":8820,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HESX1","release_manifest":"api/v1.1/release_manifest.json"}},"HEXA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXA","identifiers":{"aliases":[],"approved_symbol":"HEXA","ensembl_gene_id":"ENSG00000213614","hgnc_id":"HGNC:4878","ncbi_gene_id":3073,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEXA","release_manifest":"api/v1.1/release_manifest.json"}},"HEXA-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXA-AS1","identifiers":{"aliases":["FLJ13315"],"approved_symbol":"HEXA-AS1","ensembl_gene_id":"ENSG00000260339","hgnc_id":"HGNC:25810","ncbi_gene_id":80072,"previous_symbols":["C15orf34"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEXA-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HEXB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXB","identifiers":{"aliases":[],"approved_symbol":"HEXB","ensembl_gene_id":"ENSG00000049860","hgnc_id":"HGNC:4879","ncbi_gene_id":3074,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEXB","release_manifest":"api/v1.1/release_manifest.json"}},"HEXD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXD","identifiers":{"aliases":["FLJ23825"],"approved_symbol":"HEXD","ensembl_gene_id":"ENSG00000169660","hgnc_id":"HGNC:26307","ncbi_gene_id":284004,"previous_symbols":["HEXDC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEXD","release_manifest":"api/v1.1/release_manifest.json"}},"HEXD-IT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXD-IT1","identifiers":{"aliases":[],"approved_symbol":"HEXD-IT1","ensembl_gene_id":"ENSG00000279066","hgnc_id":"HGNC:43650","ncbi_gene_id":100505970,"previous_symbols":["HEXDC-IT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HEXD-IT1","release_manifest":"api/v1.1/release_manifest.json"}},"HEXIM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXIM1","identifiers":{"aliases":["CLP-1","HIS1","MAQ1","EDG1"],"approved_symbol":"HEXIM1","ensembl_gene_id":"ENSG00000186834","hgnc_id":"HGNC:24953","ncbi_gene_id":10614,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEXIM1","release_manifest":"api/v1.1/release_manifest.json"}},"HEXIM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEXIM2","identifiers":{"aliases":["FLJ32384"],"approved_symbol":"HEXIM2","ensembl_gene_id":"ENSG00000168517","hgnc_id":"HGNC:28591","ncbi_gene_id":124790,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEXIM2","release_manifest":"api/v1.1/release_manifest.json"}},"HEY1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEY1","identifiers":{"aliases":["HESR-1","CHF2","HESR1","HRT-1","CHF-2","HERP2","bHLHb31"],"approved_symbol":"HEY1","ensembl_gene_id":"ENSG00000164683","hgnc_id":"HGNC:4880","ncbi_gene_id":23462,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEY1","release_manifest":"api/v1.1/release_manifest.json"}},"HEY2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEY2","identifiers":{"aliases":["bHLHb32","HERP1","HESR2"],"approved_symbol":"HEY2","ensembl_gene_id":"ENSG00000135547","hgnc_id":"HGNC:4881","ncbi_gene_id":23493,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEY2","release_manifest":"api/v1.1/release_manifest.json"}},"HEYL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HEYL","identifiers":{"aliases":["bHLHb33","HEY3","HESR3"],"approved_symbol":"HEYL","ensembl_gene_id":"ENSG00000163909","hgnc_id":"HGNC:4882","ncbi_gene_id":26508,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HEYL","release_manifest":"api/v1.1/release_manifest.json"}},"HFE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HFE","identifiers":{"aliases":["HLA-H","HFE1"],"approved_symbol":"HFE","ensembl_gene_id":"ENSG00000010704","hgnc_id":"HGNC:4886","ncbi_gene_id":3077,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HFE","release_manifest":"api/v1.1/release_manifest.json"}},"HFM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HFM1","identifiers":{"aliases":["MER3","FLJ39011","FLJ36760"],"approved_symbol":"HFM1","ensembl_gene_id":"ENSG00000162669","hgnc_id":"HGNC:20193","ncbi_gene_id":164045,"previous_symbols":["SEC63D1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HFM1","release_manifest":"api/v1.1/release_manifest.json"}},"HGD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HGD","identifiers":{"aliases":["HGO"],"approved_symbol":"HGD","ensembl_gene_id":"ENSG00000113924","hgnc_id":"HGNC:4892","ncbi_gene_id":3081,"previous_symbols":["AKU"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HGD","release_manifest":"api/v1.1/release_manifest.json"}},"HGF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HGF","identifiers":{"aliases":["SF","F-TCF","HGFB","HPTA"],"approved_symbol":"HGF","ensembl_gene_id":"ENSG00000019991","hgnc_id":"HGNC:4893","ncbi_gene_id":3082,"previous_symbols":["DFNB39"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HGF","release_manifest":"api/v1.1/release_manifest.json"}},"HGH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HGH1","identifiers":{"aliases":["FLJ40907","LOC51236","Brp16"],"approved_symbol":"HGH1","ensembl_gene_id":"ENSG00000235173","hgnc_id":"HGNC:24161","ncbi_gene_id":51236,"previous_symbols":["C8orf30A","FAM203B","C8orf30B","FAM203A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HGH1","release_manifest":"api/v1.1/release_manifest.json"}},"HGS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HGS","identifiers":{"aliases":["Hrs","ZFYVE8","Vps27"],"approved_symbol":"HGS","ensembl_gene_id":"ENSG00000185359","hgnc_id":"HGNC:4897","ncbi_gene_id":9146,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HGS","release_manifest":"api/v1.1/release_manifest.json"}},"HGSNAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HGSNAT","identifiers":{"aliases":["FLJ32731","HGNAT"],"approved_symbol":"HGSNAT","ensembl_gene_id":"ENSG00000165102","hgnc_id":"HGNC:26527","ncbi_gene_id":138050,"previous_symbols":["TMEM76"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HGSNAT","release_manifest":"api/v1.1/release_manifest.json"}},"HHAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHAT","identifiers":{"aliases":["FLJ10724","MART-2","MART2","Skn","ski","rasp","sit","GUP2"],"approved_symbol":"HHAT","ensembl_gene_id":"ENSG00000054392","hgnc_id":"HGNC:18270","ncbi_gene_id":55733,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HHAT","release_manifest":"api/v1.1/release_manifest.json"}},"HHATL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHATL","identifiers":{"aliases":["MG56","KIAA1173","OACT3","MSTP002","MBOAT3"],"approved_symbol":"HHATL","ensembl_gene_id":"ENSG00000010282","hgnc_id":"HGNC:13242","ncbi_gene_id":57467,"previous_symbols":["C3orf3","GUP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HHATL","release_manifest":"api/v1.1/release_manifest.json"}},"HHEX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHEX","identifiers":{"aliases":["HEX","HOX11L-PEN"],"approved_symbol":"HHEX","ensembl_gene_id":"ENSG00000152804","hgnc_id":"HGNC:4901","ncbi_gene_id":3087,"previous_symbols":["PRHX"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HHEX","release_manifest":"api/v1.1/release_manifest.json"}},"HHIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHIP","identifiers":{"aliases":["HIP","FLJ20992"],"approved_symbol":"HHIP","ensembl_gene_id":"ENSG00000164161","hgnc_id":"HGNC:14866","ncbi_gene_id":64399,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HHIP","release_manifest":"api/v1.1/release_manifest.json"}},"HHIP-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHIP-AS1","identifiers":{"aliases":["HHAS1"],"approved_symbol":"HHIP-AS1","ensembl_gene_id":"ENSG00000248890","hgnc_id":"HGNC:44182","ncbi_gene_id":646576,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HHIP-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HHIPL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHIPL1","identifiers":{"aliases":[],"approved_symbol":"HHIPL1","ensembl_gene_id":"ENSG00000182218","hgnc_id":"HGNC:19710","ncbi_gene_id":84439,"previous_symbols":["KIAA1822"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HHIPL1","release_manifest":"api/v1.1/release_manifest.json"}},"HHIPL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHIPL2","identifiers":{"aliases":["FLJ13840"],"approved_symbol":"HHIPL2","ensembl_gene_id":"ENSG00000143512","hgnc_id":"HGNC:25842","ncbi_gene_id":79802,"previous_symbols":["KIAA1822L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HHIPL2","release_manifest":"api/v1.1/release_manifest.json"}},"HHLA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HHLA3","identifiers":{"approved_symbol":"HHLA3","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HHLA3","release_manifest":"api/v1.1/release_manifest.json"}},"HIBADH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIBADH","identifiers":{"aliases":["NS5ATP1"],"approved_symbol":"HIBADH","ensembl_gene_id":"ENSG00000106049","hgnc_id":"HGNC:4907","ncbi_gene_id":11112,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIBADH","release_manifest":"api/v1.1/release_manifest.json"}},"HIBCH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIBCH","identifiers":{"aliases":[],"approved_symbol":"HIBCH","ensembl_gene_id":"ENSG00000198130","hgnc_id":"HGNC:4908","ncbi_gene_id":26275,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIBCH","release_manifest":"api/v1.1/release_manifest.json"}},"HIC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIC1","identifiers":{"aliases":["ZBTB29","ZNF901"],"approved_symbol":"HIC1","ensembl_gene_id":"ENSG00000177374","hgnc_id":"HGNC:4909","ncbi_gene_id":3090,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIC1","release_manifest":"api/v1.1/release_manifest.json"}},"HIC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIC2","identifiers":{"aliases":["KIAA1020","HRG22","ZBTB30","ZNF907"],"approved_symbol":"HIC2","ensembl_gene_id":"ENSG00000169635","hgnc_id":"HGNC:18595","ncbi_gene_id":23119,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIC2","release_manifest":"api/v1.1/release_manifest.json"}},"HID1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HID1","identifiers":{"aliases":["DMC1","HID-1"],"approved_symbol":"HID1","ensembl_gene_id":"ENSG00000167861","hgnc_id":"HGNC:15736","ncbi_gene_id":283987,"previous_symbols":["C17orf28"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HID1","release_manifest":"api/v1.1/release_manifest.json"}},"HID1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HID1-AS1","identifiers":{"aliases":[],"approved_symbol":"HID1-AS1","ensembl_gene_id":"ENSG00000263586","hgnc_id":"HGNC:51181","ncbi_gene_id":102723641,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HID1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HIF1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIF1A","identifiers":{"aliases":["MOP1","HIF-1alpha","PASD8","HIF1","bHLHe78"],"approved_symbol":"HIF1A","ensembl_gene_id":"ENSG00000100644","hgnc_id":"HGNC:4910","ncbi_gene_id":3091,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HIF1A","release_manifest":"api/v1.1/release_manifest.json"}},"HIF1A-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIF1A-AS1","identifiers":{"aliases":["HIFAL","5'aHIF-1A"],"approved_symbol":"HIF1A-AS1","ensembl_gene_id":"ENSG00000258777","hgnc_id":"HGNC:43014","ncbi_gene_id":100750246,"previous_symbols":["HIF1A-AS3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIF1A-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HIF1A-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIF1A-AS3","identifiers":{"approved_symbol":"HIF1A-AS3","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIF1A-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"HIF1AN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIF1AN","identifiers":{"aliases":["FLJ20615","DKFZp762F1811","FLJ22027","FIH1"],"approved_symbol":"HIF1AN","ensembl_gene_id":"ENSG00000166135","hgnc_id":"HGNC:17113","ncbi_gene_id":55662,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIF1AN","release_manifest":"api/v1.1/release_manifest.json"}},"HIF3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIF3A","identifiers":{"aliases":["IPAS","MOP7","PASD7","bHLHe17"],"approved_symbol":"HIF3A","ensembl_gene_id":"ENSG00000124440","hgnc_id":"HGNC:15825","ncbi_gene_id":64344,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIF3A","detailed_audit_record":"gene/HIF3A/audit","legacy_api_record":"api/v1/genes/HIF3A.json","release_manifest":"api/v1.1/release_manifest.json"}},"HIGD1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIGD1A","identifiers":{"aliases":["HIG1","DKFZP564K247","RCF1A"],"approved_symbol":"HIGD1A","ensembl_gene_id":"ENSG00000181061","hgnc_id":"HGNC:29527","ncbi_gene_id":25994,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIGD1A","release_manifest":"api/v1.1/release_manifest.json"}},"HIGD1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIGD1B","identifiers":{"aliases":["CLST11240","CLST11240-15"],"approved_symbol":"HIGD1B","ensembl_gene_id":"ENSG00000131097","hgnc_id":"HGNC:24318","ncbi_gene_id":51751,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HIGD1B","release_manifest":"api/v1.1/release_manifest.json"}},"HIGD1C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIGD1C","identifiers":{"aliases":["Gm921"],"approved_symbol":"HIGD1C","ensembl_gene_id":"ENSG00000214511","hgnc_id":"HGNC:28044","ncbi_gene_id":613227,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIGD1C","release_manifest":"api/v1.1/release_manifest.json"}},"HIGD2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIGD2A","identifiers":{"aliases":["MGC2198","RCF1B"],"approved_symbol":"HIGD2A","ensembl_gene_id":"ENSG00000146066","hgnc_id":"HGNC:28311","ncbi_gene_id":192286,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIGD2A","release_manifest":"api/v1.1/release_manifest.json"}},"HIKESHI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIKESHI","identifiers":{"aliases":["HSPC138","HSPC179","OPI10"],"approved_symbol":"HIKESHI","ensembl_gene_id":"ENSG00000149196","hgnc_id":"HGNC:26938","ncbi_gene_id":51501,"previous_symbols":["C11orf73"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HIKESHI","release_manifest":"api/v1.1/release_manifest.json"}},"HILPDA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HILPDA","identifiers":{"aliases":["FLJ21076","HIG-2","HIG2"],"approved_symbol":"HILPDA","ensembl_gene_id":"ENSG00000135245","hgnc_id":"HGNC:28859","ncbi_gene_id":29923,"previous_symbols":["C7orf68"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HILPDA","release_manifest":"api/v1.1/release_manifest.json"}},"HINFP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HINFP","identifiers":{"aliases":["DKFZP434F162","HiNF-P","ZNF743"],"approved_symbol":"HINFP","ensembl_gene_id":"ENSG00000172273","hgnc_id":"HGNC:17850","ncbi_gene_id":25988,"previous_symbols":["MIZF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HINFP","release_manifest":"api/v1.1/release_manifest.json"}},"HINT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HINT1","identifiers":{"aliases":["PKCI-1"],"approved_symbol":"HINT1","ensembl_gene_id":"ENSG00000169567","hgnc_id":"HGNC:4912","ncbi_gene_id":3094,"previous_symbols":["PRKCNH1","HINT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HINT1","release_manifest":"api/v1.1/release_manifest.json"}},"HINT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HINT2","identifiers":{"aliases":[],"approved_symbol":"HINT2","ensembl_gene_id":"ENSG00000137133","hgnc_id":"HGNC:18344","ncbi_gene_id":84681,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HINT2","release_manifest":"api/v1.1/release_manifest.json"}},"HINT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HINT3","identifiers":{"aliases":["FLJ33126","HINT4"],"approved_symbol":"HINT3","ensembl_gene_id":"ENSG00000111911","hgnc_id":"HGNC:18468","ncbi_gene_id":135114,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HINT3","release_manifest":"api/v1.1/release_manifest.json"}},"HIP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIP1","identifiers":{"aliases":["ILWEQ"],"approved_symbol":"HIP1","ensembl_gene_id":"ENSG00000127946","hgnc_id":"HGNC:4913","ncbi_gene_id":3092,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIP1","release_manifest":"api/v1.1/release_manifest.json"}},"HIP1R":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIP1R","identifiers":{"aliases":["KIAA0655","HIP3","HIP12","FLJ14000","ILWEQ"],"approved_symbol":"HIP1R","ensembl_gene_id":"ENSG00000130787","hgnc_id":"HGNC:18415","ncbi_gene_id":9026,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIP1R","release_manifest":"api/v1.1/release_manifest.json"}},"HIPK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIPK1","identifiers":{"aliases":["KIAA0630","Myak","MGC26642","Nbak2","MGC33446","MGC33548"],"approved_symbol":"HIPK1","ensembl_gene_id":"ENSG00000163349","hgnc_id":"HGNC:19006","ncbi_gene_id":204851,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIPK1","release_manifest":"api/v1.1/release_manifest.json"}},"HIPK1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIPK1-AS1","identifiers":{"aliases":[],"approved_symbol":"HIPK1-AS1","ensembl_gene_id":"ENSG00000235527","hgnc_id":"HGNC:50576","ncbi_gene_id":101928846,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIPK1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HIPK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIPK2","identifiers":{"aliases":[],"approved_symbol":"HIPK2","ensembl_gene_id":"ENSG00000064393","hgnc_id":"HGNC:14402","ncbi_gene_id":28996,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HIPK2","release_manifest":"api/v1.1/release_manifest.json"}},"HIPK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIPK3","identifiers":{"aliases":["PKY","DYRK6","YAK1","FIST3"],"approved_symbol":"HIPK3","ensembl_gene_id":"ENSG00000110422","hgnc_id":"HGNC:4915","ncbi_gene_id":10114,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIPK3","release_manifest":"api/v1.1/release_manifest.json"}},"HIPK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIPK4","identifiers":{"aliases":["FLJ32818"],"approved_symbol":"HIPK4","ensembl_gene_id":"ENSG00000160396","hgnc_id":"HGNC:19007","ncbi_gene_id":147746,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIPK4","release_manifest":"api/v1.1/release_manifest.json"}},"HIRA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIRA","identifiers":{"aliases":["DGCR1","TUP1"],"approved_symbol":"HIRA","ensembl_gene_id":"ENSG00000100084","hgnc_id":"HGNC:4916","ncbi_gene_id":7290,"previous_symbols":["TUPLE1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIRA","release_manifest":"api/v1.1/release_manifest.json"}},"HIRIP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIRIP3","identifiers":{"aliases":[],"approved_symbol":"HIRIP3","ensembl_gene_id":"ENSG00000149929","hgnc_id":"HGNC:4917","ncbi_gene_id":8479,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIRIP3","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H1A","identifiers":{"approved_symbol":"HIST1H1A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST1H1A","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H1B","identifiers":{"approved_symbol":"HIST1H1B","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST1H1B","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H1D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H1D","identifiers":{"approved_symbol":"HIST1H1D","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST1H1D","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H2AC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H2AC","identifiers":{"approved_symbol":"HIST1H2AC","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST1H2AC","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H2AD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H2AD","identifiers":{"approved_symbol":"HIST1H2AD","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST1H2AD","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H2AE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H2AE","identifiers":{"approved_symbol":"HIST1H2AE","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST1H2AE","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H2BH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H2BH","identifiers":{"approved_symbol":"HIST1H2BH","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST1H2BH","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H2BJ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H2BJ","identifiers":{"approved_symbol":"HIST1H2BJ","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST1H2BJ","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H2BK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H2BK","identifiers":{"approved_symbol":"HIST1H2BK","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST1H2BK","release_manifest":"api/v1.1/release_manifest.json"}},"HIST1H3D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST1H3D","identifiers":{"approved_symbol":"HIST1H3D","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST1H3D","release_manifest":"api/v1.1/release_manifest.json"}},"HIST2H2AB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST2H2AB","identifiers":{"approved_symbol":"HIST2H2AB","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST2H2AB","release_manifest":"api/v1.1/release_manifest.json"}},"HIST2H2AC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST2H2AC","identifiers":{"approved_symbol":"HIST2H2AC","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST2H2AC","release_manifest":"api/v1.1/release_manifest.json"}},"HIST2H3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST2H3A","identifiers":{"approved_symbol":"HIST2H3A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HIST2H3A","release_manifest":"api/v1.1/release_manifest.json"}},"HIST3H2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST3H2A","identifiers":{"approved_symbol":"HIST3H2A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST3H2A","release_manifest":"api/v1.1/release_manifest.json"}},"HIST3H2BB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIST3H2BB","identifiers":{"approved_symbol":"HIST3H2BB","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HIST3H2BB","release_manifest":"api/v1.1/release_manifest.json"}},"HIVEP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIVEP1","identifiers":{"aliases":["CIRIP","MBP-1","CRYBP1","PRDII-BF1","ZAS1","Schnurri-1","ZNF40A"],"approved_symbol":"HIVEP1","ensembl_gene_id":"ENSG00000095951","hgnc_id":"HGNC:4920","ncbi_gene_id":3096,"previous_symbols":["ZNF40"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIVEP1","release_manifest":"api/v1.1/release_manifest.json"}},"HIVEP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIVEP2","identifiers":{"aliases":["MBP-2","HIV-EP2","MIBP1","ZAS2","Schnurri-2","ZNF40B"],"approved_symbol":"HIVEP2","ensembl_gene_id":"ENSG00000010818","hgnc_id":"HGNC:4921","ncbi_gene_id":3097,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIVEP2","release_manifest":"api/v1.1/release_manifest.json"}},"HIVEP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HIVEP3","identifiers":{"aliases":["KRC","KBP1","KBP-1","SHN3","FLJ16752","KIAA1555","ZAS3","Schnurri-3","ZNF40C"],"approved_symbol":"HIVEP3","ensembl_gene_id":"ENSG00000127124","hgnc_id":"HGNC:13561","ncbi_gene_id":59269,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HIVEP3","release_manifest":"api/v1.1/release_manifest.json"}},"HJURP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HJURP","identifiers":{"aliases":["DKFZp762E1312","URLC9","hFLEG1","FAKTS"],"approved_symbol":"HJURP","ensembl_gene_id":"ENSG00000123485","hgnc_id":"HGNC:25444","ncbi_gene_id":55355,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HJURP","release_manifest":"api/v1.1/release_manifest.json"}},"HJV":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HJV","identifiers":{"aliases":["JH","HFE2A","RGMC","hemojuvelin","haemojuvelin"],"approved_symbol":"HJV","ensembl_gene_id":"ENSG00000168509","hgnc_id":"HGNC:4887","ncbi_gene_id":148738,"previous_symbols":["HFE2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HJV","release_manifest":"api/v1.1/release_manifest.json"}},"HK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HK1","identifiers":{"aliases":["HKI"],"approved_symbol":"HK1","ensembl_gene_id":"ENSG00000156515","hgnc_id":"HGNC:4922","ncbi_gene_id":3098,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HK1","release_manifest":"api/v1.1/release_manifest.json"}},"HK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HK2","identifiers":{"aliases":["HKII"],"approved_symbol":"HK2","ensembl_gene_id":"ENSG00000159399","hgnc_id":"HGNC:4923","ncbi_gene_id":3099,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HK2","release_manifest":"api/v1.1/release_manifest.json"}},"HK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HK3","identifiers":{"aliases":["HKIII"],"approved_symbol":"HK3","ensembl_gene_id":"ENSG00000160883","hgnc_id":"HGNC:4925","ncbi_gene_id":3101,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HK3","release_manifest":"api/v1.1/release_manifest.json"}},"HKDC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HKDC1","identifiers":{"aliases":["FLJ37767","FLJ22761"],"approved_symbol":"HKDC1","ensembl_gene_id":"ENSG00000156510","hgnc_id":"HGNC:23302","ncbi_gene_id":80201,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HKDC1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-A","identifiers":{"aliases":[],"approved_symbol":"HLA-A","ensembl_gene_id":"ENSG00000206503","hgnc_id":"HGNC:4931","ncbi_gene_id":3105,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-A","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-B","identifiers":{"aliases":[],"approved_symbol":"HLA-B","ensembl_gene_id":"ENSG00000234745","hgnc_id":"HGNC:4932","ncbi_gene_id":3106,"previous_symbols":["AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-B","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-C","identifiers":{"aliases":[],"approved_symbol":"HLA-C","ensembl_gene_id":"ENSG00000204525","hgnc_id":"HGNC:4933","ncbi_gene_id":3107,"previous_symbols":["HLA-JY3","D6S204","PSORS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-C","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DMA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DMA","identifiers":{"aliases":["D6S222E","RING6"],"approved_symbol":"HLA-DMA","ensembl_gene_id":"ENSG00000204257","hgnc_id":"HGNC:4934","ncbi_gene_id":3108,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DMA","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DMB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DMB","identifiers":{"aliases":["D6S221E","RING7"],"approved_symbol":"HLA-DMB","ensembl_gene_id":"ENSG00000242574","hgnc_id":"HGNC:4935","ncbi_gene_id":3109,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DMB","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DOA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DOA","identifiers":{"aliases":["HLA-D0-alpha"],"approved_symbol":"HLA-DOA","ensembl_gene_id":"ENSG00000204252","hgnc_id":"HGNC:4936","ncbi_gene_id":3111,"previous_symbols":["HLA-DZA","HLA-DNA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-DOA","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DOB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DOB","identifiers":{"aliases":[],"approved_symbol":"HLA-DOB","ensembl_gene_id":"ENSG00000241106","hgnc_id":"HGNC:4937","ncbi_gene_id":3112,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-DOB","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DPA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DPA1","identifiers":{"aliases":[],"approved_symbol":"HLA-DPA1","ensembl_gene_id":"ENSG00000231389","hgnc_id":"HGNC:4938","ncbi_gene_id":3113,"previous_symbols":["HLA-DP1A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DPA1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DPB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DPB1","identifiers":{"aliases":[],"approved_symbol":"HLA-DPB1","ensembl_gene_id":"ENSG00000223865","hgnc_id":"HGNC:4940","ncbi_gene_id":3115,"previous_symbols":["HLA-DP1B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DPB1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DQA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DQA1","identifiers":{"aliases":["CELIAC1"],"approved_symbol":"HLA-DQA1","ensembl_gene_id":"ENSG00000196735","hgnc_id":"HGNC:4942","ncbi_gene_id":3117,"previous_symbols":["HLA-DQA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-DQA1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DQA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DQA2","identifiers":{"aliases":[],"approved_symbol":"HLA-DQA2","ensembl_gene_id":"ENSG00000237541","hgnc_id":"HGNC:4943","ncbi_gene_id":3118,"previous_symbols":["HLA-DXA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DQA2","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DQB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DQB1","identifiers":{"aliases":["IDDM1","CELIAC1"],"approved_symbol":"HLA-DQB1","ensembl_gene_id":"ENSG00000179344","hgnc_id":"HGNC:4944","ncbi_gene_id":3119,"previous_symbols":["HLA-DQB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DQB1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DQB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DQB2","identifiers":{"aliases":[],"approved_symbol":"HLA-DQB2","ensembl_gene_id":"ENSG00000232629","hgnc_id":"HGNC:4945","ncbi_gene_id":3120,"previous_symbols":["HLA-DXB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-DQB2","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DRA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DRA","identifiers":{"aliases":[],"approved_symbol":"HLA-DRA","ensembl_gene_id":"ENSG00000204287","hgnc_id":"HGNC:4947","ncbi_gene_id":3122,"previous_symbols":["HLA-DRA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-DRA","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DRB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DRB1","identifiers":{"aliases":[],"approved_symbol":"HLA-DRB1","ensembl_gene_id":"ENSG00000196126","hgnc_id":"HGNC:4948","ncbi_gene_id":3123,"previous_symbols":["HLA-DR1B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-DRB1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-DRB5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-DRB5","identifiers":{"aliases":[],"approved_symbol":"HLA-DRB5","ensembl_gene_id":"ENSG00000198502","hgnc_id":"HGNC:4953","ncbi_gene_id":3127,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-DRB5","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-E":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-E","identifiers":{"aliases":[],"approved_symbol":"HLA-E","ensembl_gene_id":"ENSG00000204592","hgnc_id":"HGNC:4962","ncbi_gene_id":3133,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-E","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-F":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-F","identifiers":{"aliases":[],"approved_symbol":"HLA-F","ensembl_gene_id":"ENSG00000204642","hgnc_id":"HGNC:4963","ncbi_gene_id":3134,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-F","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-F-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-F-AS1","identifiers":{"aliases":[],"approved_symbol":"HLA-F-AS1","ensembl_gene_id":"ENSG00000214922","hgnc_id":"HGNC:26645","ncbi_gene_id":285830,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLA-F-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HLA-G":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLA-G","identifiers":{"aliases":[],"approved_symbol":"HLA-G","ensembl_gene_id":"ENSG00000204632","hgnc_id":"HGNC:4964","ncbi_gene_id":3135,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLA-G","release_manifest":"api/v1.1/release_manifest.json"}},"HLCS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLCS","identifiers":{"aliases":["HCS"],"approved_symbol":"HLCS","ensembl_gene_id":"ENSG00000159267","hgnc_id":"HGNC:4976","ncbi_gene_id":3141,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLCS","release_manifest":"api/v1.1/release_manifest.json"}},"HLF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLF","identifiers":{"aliases":["MGC33822"],"approved_symbol":"HLF","ensembl_gene_id":"ENSG00000108924","hgnc_id":"HGNC:4977","ncbi_gene_id":3131,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLF","release_manifest":"api/v1.1/release_manifest.json"}},"HLTF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLTF","identifiers":{"aliases":["HIP116A","HLTF1","RNF80"],"approved_symbol":"HLTF","ensembl_gene_id":"ENSG00000071794","hgnc_id":"HGNC:11099","ncbi_gene_id":6596,"previous_symbols":["SNF2L3","SMARCA3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLTF","release_manifest":"api/v1.1/release_manifest.json"}},"HLX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLX","identifiers":{"aliases":["HB24"],"approved_symbol":"HLX","ensembl_gene_id":"ENSG00000136630","hgnc_id":"HGNC:4978","ncbi_gene_id":3142,"previous_symbols":["HLX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HLX","release_manifest":"api/v1.1/release_manifest.json"}},"HLX-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HLX-AS1","identifiers":{"aliases":[],"approved_symbol":"HLX-AS1","ensembl_gene_id":"ENSG00000257551","hgnc_id":"HGNC:42509","ncbi_gene_id":100873924,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HLX-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HM13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HM13","identifiers":{"aliases":["H13","dJ324O17.1","SPP","PSL3","IMP1","IMPAS","PSENL3","SPPL1"],"approved_symbol":"HM13","ensembl_gene_id":"ENSG00000101294","hgnc_id":"HGNC:16435","ncbi_gene_id":81502,"previous_symbols":["HM13-IT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HM13","release_manifest":"api/v1.1/release_manifest.json"}},"HM13-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HM13-AS1","identifiers":{"aliases":[],"approved_symbol":"HM13-AS1","ensembl_gene_id":"ENSG00000230613","hgnc_id":"HGNC:41940","ncbi_gene_id":100874042,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HM13-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HMBOX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMBOX1","identifiers":{"aliases":["HNF1LA","PBHNF","FLJ21616","HOT1"],"approved_symbol":"HMBOX1","ensembl_gene_id":"ENSG00000147421","hgnc_id":"HGNC:26137","ncbi_gene_id":79618,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMBOX1","release_manifest":"api/v1.1/release_manifest.json"}},"HMBS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMBS","identifiers":{"aliases":[],"approved_symbol":"HMBS","ensembl_gene_id":"ENSG00000256269","hgnc_id":"HGNC:4982","ncbi_gene_id":3145,"previous_symbols":["PBGD","UPS","PORC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMBS","release_manifest":"api/v1.1/release_manifest.json"}},"HMCES":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMCES","identifiers":{"aliases":["DC12","SRAPD1"],"approved_symbol":"HMCES","ensembl_gene_id":"ENSG00000183624","hgnc_id":"HGNC:24446","ncbi_gene_id":56941,"previous_symbols":["C3orf37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMCES","release_manifest":"api/v1.1/release_manifest.json"}},"HMCN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMCN1","identifiers":{"aliases":["FBLN6","FIBL6","FIBL-6"],"approved_symbol":"HMCN1","ensembl_gene_id":"ENSG00000143341","hgnc_id":"HGNC:19194","ncbi_gene_id":83872,"previous_symbols":["ARMD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMCN1","release_manifest":"api/v1.1/release_manifest.json"}},"HMCN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMCN2","identifiers":{"aliases":["DKFZp434P0216","FLJ23816"],"approved_symbol":"HMCN2","ensembl_gene_id":"ENSG00000148357","hgnc_id":"HGNC:21293","ncbi_gene_id":256158,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMCN2","release_manifest":"api/v1.1/release_manifest.json"}},"HMG20A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMG20A","identifiers":{"aliases":["HMGX1","FLJ10739","HMGXB1"],"approved_symbol":"HMG20A","ensembl_gene_id":"ENSG00000140382","hgnc_id":"HGNC:5001","ncbi_gene_id":10363,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMG20A","release_manifest":"api/v1.1/release_manifest.json"}},"HMG20B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMG20B","identifiers":{"aliases":["SOXL","HMGX2","BRAF35","SMARCE1r","BRAF25","HMGXB2"],"approved_symbol":"HMG20B","ensembl_gene_id":"ENSG00000064961","hgnc_id":"HGNC:5002","ncbi_gene_id":10362,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMG20B","release_manifest":"api/v1.1/release_manifest.json"}},"HMGA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGA1","identifiers":{"aliases":[],"approved_symbol":"HMGA1","ensembl_gene_id":"ENSG00000137309","hgnc_id":"HGNC:5010","ncbi_gene_id":3159,"previous_symbols":["HMGIY"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGA1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGA1P4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGA1P4","identifiers":{"aliases":[],"approved_symbol":"HMGA1P4","ensembl_gene_id":"ENSG00000234705","hgnc_id":"HGNC:39093","ncbi_gene_id":100506080,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGA1P4","release_manifest":"api/v1.1/release_manifest.json"}},"HMGA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGA2","identifiers":{"aliases":["BABL","LIPO"],"approved_symbol":"HMGA2","ensembl_gene_id":"ENSG00000149948","hgnc_id":"HGNC:5009","ncbi_gene_id":8091,"previous_symbols":["HMGIC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGA2","release_manifest":"api/v1.1/release_manifest.json"}},"HMGA2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGA2-AS1","identifiers":{"aliases":["RP11-366L20.2"],"approved_symbol":"HMGA2-AS1","ensembl_gene_id":"ENSG00000197301","hgnc_id":"HGNC:53973","ncbi_gene_id":100129940,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HMGA2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGB1","identifiers":{"aliases":["HMG3","SBP-1","DKFZp686A04236"],"approved_symbol":"HMGB1","ensembl_gene_id":"ENSG00000189403","hgnc_id":"HGNC:4983","ncbi_gene_id":3146,"previous_symbols":["HMG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGB1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGB2","identifiers":{"aliases":[],"approved_symbol":"HMGB2","ensembl_gene_id":"ENSG00000164104","hgnc_id":"HGNC:5000","ncbi_gene_id":3148,"previous_symbols":["HMG2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGB2","release_manifest":"api/v1.1/release_manifest.json"}},"HMGB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGB3","identifiers":{"aliases":["HMG2A","MGC90319"],"approved_symbol":"HMGB3","ensembl_gene_id":"ENSG00000029993","hgnc_id":"HGNC:5004","ncbi_gene_id":3149,"previous_symbols":["HMG4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGB3","release_manifest":"api/v1.1/release_manifest.json"}},"HMGCL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGCL","identifiers":{"aliases":["HL","HMGCL1"],"approved_symbol":"HMGCL","ensembl_gene_id":"ENSG00000117305","hgnc_id":"HGNC:5005","ncbi_gene_id":3155,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGCL","release_manifest":"api/v1.1/release_manifest.json"}},"HMGCLL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGCLL1","identifiers":{"aliases":["DKFZP434G1411","bA418P12.1","er-cHL"],"approved_symbol":"HMGCLL1","ensembl_gene_id":"ENSG00000146151","hgnc_id":"HGNC:21359","ncbi_gene_id":54511,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGCLL1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGCR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGCR","identifiers":{"aliases":[],"approved_symbol":"HMGCR","ensembl_gene_id":"ENSG00000113161","hgnc_id":"HGNC:5006","ncbi_gene_id":3156,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGCR","release_manifest":"api/v1.1/release_manifest.json"}},"HMGCS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGCS1","identifiers":{"aliases":[],"approved_symbol":"HMGCS1","ensembl_gene_id":"ENSG00000112972","hgnc_id":"HGNC:5007","ncbi_gene_id":3157,"previous_symbols":["HMGCS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGCS1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGCS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGCS2","identifiers":{"aliases":[],"approved_symbol":"HMGCS2","ensembl_gene_id":"ENSG00000134240","hgnc_id":"HGNC:5008","ncbi_gene_id":3158,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HMGCS2","release_manifest":"api/v1.1/release_manifest.json"}},"HMGN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGN1","identifiers":{"aliases":["FLJ27265","FLJ31471","MGC104230","MGC117425"],"approved_symbol":"HMGN1","ensembl_gene_id":"ENSG00000205581","hgnc_id":"HGNC:4984","ncbi_gene_id":3150,"previous_symbols":["HMG14"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGN1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGN2","identifiers":{"aliases":[],"approved_symbol":"HMGN2","ensembl_gene_id":"ENSG00000198830","hgnc_id":"HGNC:4986","ncbi_gene_id":3151,"previous_symbols":["HMG17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGN2","release_manifest":"api/v1.1/release_manifest.json"}},"HMGN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGN3","identifiers":{"aliases":[],"approved_symbol":"HMGN3","ensembl_gene_id":"ENSG00000118418","hgnc_id":"HGNC:12312","ncbi_gene_id":9324,"previous_symbols":["TRIP7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGN3","release_manifest":"api/v1.1/release_manifest.json"}},"HMGN3-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGN3-AS1","identifiers":{"aliases":[],"approved_symbol":"HMGN3-AS1","ensembl_gene_id":"ENSG00000270362","hgnc_id":"HGNC:48984","ncbi_gene_id":100288198,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGN3-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HMGN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGN4","identifiers":{"aliases":["NHC"],"approved_symbol":"HMGN4","ensembl_gene_id":"ENSG00000182952","hgnc_id":"HGNC:4989","ncbi_gene_id":10473,"previous_symbols":["HMG17L3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGN4","release_manifest":"api/v1.1/release_manifest.json"}},"HMGN5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGN5","identifiers":{"aliases":[],"approved_symbol":"HMGN5","ensembl_gene_id":"ENSG00000198157","hgnc_id":"HGNC:8013","ncbi_gene_id":79366,"previous_symbols":["NSBP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGN5","release_manifest":"api/v1.1/release_manifest.json"}},"HMGXB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGXB3","identifiers":{"aliases":["SMF","KIAA0194"],"approved_symbol":"HMGXB3","ensembl_gene_id":"ENSG00000113716","hgnc_id":"HGNC:28982","ncbi_gene_id":22993,"previous_symbols":["HMGX3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGXB3","release_manifest":"api/v1.1/release_manifest.json"}},"HMGXB4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMGXB4","identifiers":{"aliases":["THC211630","P53N"],"approved_symbol":"HMGXB4","ensembl_gene_id":"ENSG00000100281","hgnc_id":"HGNC:5003","ncbi_gene_id":10042,"previous_symbols":["HMG2L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMGXB4","release_manifest":"api/v1.1/release_manifest.json"}},"HMMR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMMR","identifiers":{"aliases":["RHAMM","CD168"],"approved_symbol":"HMMR","ensembl_gene_id":"ENSG00000072571","hgnc_id":"HGNC:5012","ncbi_gene_id":3161,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMMR","release_manifest":"api/v1.1/release_manifest.json"}},"HMOX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMOX1","identifiers":{"aliases":["bK286B10","HO-1"],"approved_symbol":"HMOX1","ensembl_gene_id":"ENSG00000100292","hgnc_id":"HGNC:5013","ncbi_gene_id":3162,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMOX1","release_manifest":"api/v1.1/release_manifest.json"}},"HMOX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMOX2","identifiers":{"aliases":["HO-2"],"approved_symbol":"HMOX2","ensembl_gene_id":"ENSG00000103415","hgnc_id":"HGNC:5014","ncbi_gene_id":3163,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HMOX2","release_manifest":"api/v1.1/release_manifest.json"}},"HMX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HMX1","identifiers":{"aliases":["H6","NKX5-3"],"approved_symbol":"HMX1","ensembl_gene_id":"ENSG00000215612","hgnc_id":"HGNC:5017","ncbi_gene_id":3166,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HMX1","release_manifest":"api/v1.1/release_manifest.json"}},"HNF1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNF1A","identifiers":{"aliases":["HNF1","LFB1","HNF1α"],"approved_symbol":"HNF1A","ensembl_gene_id":"ENSG00000135100","hgnc_id":"HGNC:11621","ncbi_gene_id":6927,"previous_symbols":["MODY3","TCF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HNF1A","release_manifest":"api/v1.1/release_manifest.json"}},"HNF1A-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNF1A-AS1","identifiers":{"aliases":["FLJ38690","HAS1","HASTER"],"approved_symbol":"HNF1A-AS1","ensembl_gene_id":"ENSG00000241388","hgnc_id":"HGNC:26785","ncbi_gene_id":283460,"previous_symbols":["C12orf27","NCRNA00262"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HNF1A-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HNF1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNF1B","identifiers":{"aliases":["LFB3","VHNF1","HNF1beta","MODY5","HNF1β"],"approved_symbol":"HNF1B","ensembl_gene_id":"ENSG00000275410","hgnc_id":"HGNC:11630","ncbi_gene_id":6928,"previous_symbols":["TCF2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HNF1B","release_manifest":"api/v1.1/release_manifest.json"}},"HNF4G":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNF4G","identifiers":{"aliases":["NR2A2"],"approved_symbol":"HNF4G","ensembl_gene_id":"ENSG00000164749","hgnc_id":"HGNC:5026","ncbi_gene_id":3174,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNF4G","release_manifest":"api/v1.1/release_manifest.json"}},"HNMT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNMT","identifiers":{"aliases":["HMT"],"approved_symbol":"HNMT","ensembl_gene_id":"ENSG00000150540","hgnc_id":"HGNC:5028","ncbi_gene_id":3176,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNMT","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPA0":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPA0","identifiers":{"aliases":[],"approved_symbol":"HNRNPA0","ensembl_gene_id":"ENSG00000177733","hgnc_id":"HGNC:5030","ncbi_gene_id":10949,"previous_symbols":["HNRPA0"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPA0","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPA1","identifiers":{"aliases":["hnRNP-A1","ALS20"],"approved_symbol":"HNRNPA1","ensembl_gene_id":"ENSG00000135486","hgnc_id":"HGNC:5031","ncbi_gene_id":3178,"previous_symbols":["HNRPA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPA1","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPA1L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPA1L2","identifiers":{"aliases":["LOC144983"],"approved_symbol":"HNRNPA1L2","ensembl_gene_id":"ENSG00000139675","hgnc_id":"HGNC:27067","ncbi_gene_id":144983,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HNRNPA1L2","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPA2B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPA2B1","identifiers":{"aliases":["HNRNPA2","HNRNPB1"],"approved_symbol":"HNRNPA2B1","ensembl_gene_id":"ENSG00000122566","hgnc_id":"HGNC:5033","ncbi_gene_id":3181,"previous_symbols":["HNRPA2B1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPA2B1","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPA3","identifiers":{"aliases":[],"approved_symbol":"HNRNPA3","ensembl_gene_id":"ENSG00000170144","hgnc_id":"HGNC:24941","ncbi_gene_id":220988,"previous_symbols":["HNRPA3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPA3","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPAB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPAB","identifiers":{"aliases":["ABBP1","FLJ40338"],"approved_symbol":"HNRNPAB","ensembl_gene_id":"ENSG00000197451","hgnc_id":"HGNC:5034","ncbi_gene_id":3182,"previous_symbols":["HNRPAB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPAB","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPC","identifiers":{"aliases":[],"approved_symbol":"HNRNPC","ensembl_gene_id":"ENSG00000092199","hgnc_id":"HGNC:5035","ncbi_gene_id":3183,"previous_symbols":["HNRPC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPC","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPD","identifiers":{"aliases":[],"approved_symbol":"HNRNPD","ensembl_gene_id":"ENSG00000138668","hgnc_id":"HGNC:5036","ncbi_gene_id":3184,"previous_symbols":["AUF1","HNRPD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPD","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPDL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPDL","identifiers":{"aliases":["JKTBP","laAUF1"],"approved_symbol":"HNRNPDL","ensembl_gene_id":"ENSG00000152795","hgnc_id":"HGNC:5037","ncbi_gene_id":9987,"previous_symbols":["HNRPDL","LGMD1G"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPDL","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPF","identifiers":{"aliases":[],"approved_symbol":"HNRNPF","ensembl_gene_id":"ENSG00000169813","hgnc_id":"HGNC:5039","ncbi_gene_id":3185,"previous_symbols":["HNRPF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPF","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPH1","identifiers":{"aliases":["hnRNPH"],"approved_symbol":"HNRNPH1","ensembl_gene_id":"ENSG00000169045","hgnc_id":"HGNC:5041","ncbi_gene_id":3187,"previous_symbols":["HNRPH1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPH1","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPH2","identifiers":{"aliases":["hnRNPH'","FTP3","HNRPH'"],"approved_symbol":"HNRNPH2","ensembl_gene_id":"ENSG00000126945","hgnc_id":"HGNC:5042","ncbi_gene_id":3188,"previous_symbols":["HNRPH2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPH2","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPH3","identifiers":{"aliases":["2H9"],"approved_symbol":"HNRNPH3","ensembl_gene_id":"ENSG00000096746","hgnc_id":"HGNC:5043","ncbi_gene_id":3189,"previous_symbols":["HNRPH3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPH3","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPK","identifiers":{"aliases":["CSBP","TUNP"],"approved_symbol":"HNRNPK","ensembl_gene_id":"ENSG00000165119","hgnc_id":"HGNC:5044","ncbi_gene_id":3190,"previous_symbols":["HNRPK"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPK","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPL","identifiers":{"aliases":[],"approved_symbol":"HNRNPL","ensembl_gene_id":"ENSG00000104824","hgnc_id":"HGNC:5045","ncbi_gene_id":3191,"previous_symbols":["HNRPL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPL","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPLL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPLL","identifiers":{"aliases":[],"approved_symbol":"HNRNPLL","ensembl_gene_id":"ENSG00000143889","hgnc_id":"HGNC:25127","ncbi_gene_id":92906,"previous_symbols":["HNRPLL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPLL","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPM","identifiers":{"aliases":["HTGR1","HNRNPM4","HNRPM4","CEAR"],"approved_symbol":"HNRNPM","ensembl_gene_id":"ENSG00000099783","hgnc_id":"HGNC:5046","ncbi_gene_id":4670,"previous_symbols":["NAGR1","HNRPM"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPM","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPR","identifiers":{"aliases":["hnRNP-R"],"approved_symbol":"HNRNPR","ensembl_gene_id":"ENSG00000125944","hgnc_id":"HGNC:5047","ncbi_gene_id":10236,"previous_symbols":["HNRPR"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPR","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPU":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPU","identifiers":{"aliases":["SAF-A","FLJ37978","FLJ30202"],"approved_symbol":"HNRNPU","ensembl_gene_id":"ENSG00000153187","hgnc_id":"HGNC:5048","ncbi_gene_id":3192,"previous_symbols":["HNRPU","HNRNPU-AS1","C1orf199","NCRNA00201"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPU","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPUL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPUL1","identifiers":{"aliases":["E1B-AP5","E1BAP5","FLJ12944"],"approved_symbol":"HNRNPUL1","ensembl_gene_id":"ENSG00000105323","hgnc_id":"HGNC:17011","ncbi_gene_id":11100,"previous_symbols":["HNRPUL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPUL1","release_manifest":"api/v1.1/release_manifest.json"}},"HNRNPUL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HNRNPUL2","identifiers":{"aliases":["DKFZp762N1910"],"approved_symbol":"HNRNPUL2","ensembl_gene_id":"ENSG00000214753","hgnc_id":"HGNC:25451","ncbi_gene_id":221092,"previous_symbols":["HNRPUL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HNRNPUL2","release_manifest":"api/v1.1/release_manifest.json"}},"HOGA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOGA1","identifiers":{"aliases":["FLJ37472","DHDPS2","NPL2"],"approved_symbol":"HOGA1","ensembl_gene_id":"ENSG00000241935","hgnc_id":"HGNC:25155","ncbi_gene_id":112817,"previous_symbols":["C10orf65","DHDPSL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOGA1","release_manifest":"api/v1.1/release_manifest.json"}},"HOMER1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOMER1","identifiers":{"aliases":["Ves-1","SYN47","HOMER-1B"],"approved_symbol":"HOMER1","ensembl_gene_id":"ENSG00000152413","hgnc_id":"HGNC:17512","ncbi_gene_id":9456,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOMER1","release_manifest":"api/v1.1/release_manifest.json"}},"HOMER2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOMER2","identifiers":{"aliases":["CPD","Cupidin","Vesl-2","HOMER-2B","HOMER-2","HOMER-2A","DFNA68"],"approved_symbol":"HOMER2","ensembl_gene_id":"ENSG00000103942","hgnc_id":"HGNC:17513","ncbi_gene_id":9455,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOMER2","release_manifest":"api/v1.1/release_manifest.json"}},"HOMER3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOMER3","identifiers":{"aliases":["HOMER-3"],"approved_symbol":"HOMER3","ensembl_gene_id":"ENSG00000051128","hgnc_id":"HGNC:17514","ncbi_gene_id":9454,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOMER3","release_manifest":"api/v1.1/release_manifest.json"}},"HOMER3-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOMER3-AS1","identifiers":{"aliases":[],"approved_symbol":"HOMER3-AS1","ensembl_gene_id":"ENSG00000269019","hgnc_id":"HGNC:53775","ncbi_gene_id":102724360,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOMER3-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HOMEZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOMEZ","identifiers":{"aliases":[],"approved_symbol":"HOMEZ","ensembl_gene_id":"ENSG00000290292","hgnc_id":"HGNC:20164","ncbi_gene_id":57594,"previous_symbols":["KIAA1443"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOMEZ","release_manifest":"api/v1.1/release_manifest.json"}},"HOOK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOOK1","identifiers":{"aliases":["HK1"],"approved_symbol":"HOOK1","ensembl_gene_id":"ENSG00000134709","hgnc_id":"HGNC:19884","ncbi_gene_id":51361,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HOOK1","release_manifest":"api/v1.1/release_manifest.json"}},"HOOK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOOK2","identifiers":{"aliases":["HK2"],"approved_symbol":"HOOK2","ensembl_gene_id":"ENSG00000095066","hgnc_id":"HGNC:19885","ncbi_gene_id":29911,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOOK2","release_manifest":"api/v1.1/release_manifest.json"}},"HOOK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOOK3","identifiers":{"aliases":["HK3"],"approved_symbol":"HOOK3","ensembl_gene_id":"ENSG00000168172","hgnc_id":"HGNC:23576","ncbi_gene_id":84376,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOOK3","release_manifest":"api/v1.1/release_manifest.json"}},"HOPX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOPX","identifiers":{"aliases":["LAGY","HOP","OB1","NECC1","SMAP31"],"approved_symbol":"HOPX","ensembl_gene_id":"ENSG00000171476","hgnc_id":"HGNC:24961","ncbi_gene_id":84525,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOPX","release_manifest":"api/v1.1/release_manifest.json"}},"HORMAD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HORMAD1","identifiers":{"aliases":["DKFZP434A1315","CT46"],"approved_symbol":"HORMAD1","ensembl_gene_id":"ENSG00000143452","hgnc_id":"HGNC:25245","ncbi_gene_id":84072,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HORMAD1","release_manifest":"api/v1.1/release_manifest.json"}},"HORMAD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HORMAD2","identifiers":{"aliases":["MGC26710","CT46.2"],"approved_symbol":"HORMAD2","ensembl_gene_id":"ENSG00000176635","hgnc_id":"HGNC:28383","ncbi_gene_id":150280,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HORMAD2","release_manifest":"api/v1.1/release_manifest.json"}},"HORMAD2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HORMAD2-AS1","identifiers":{"aliases":["MTMR3-AS1","NONHSAG033653"],"approved_symbol":"HORMAD2-AS1","ensembl_gene_id":"ENSG00000227117","hgnc_id":"HGNC:50729","ncbi_gene_id":101929664,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HORMAD2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HOTAIR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOTAIR","identifiers":{"aliases":["HOXC-AS4","HOXC11-AS1","NCRNA00072"],"approved_symbol":"HOTAIR","ensembl_gene_id":"ENSG00000228630","hgnc_id":"HGNC:33510","ncbi_gene_id":100124700,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOTAIR","release_manifest":"api/v1.1/release_manifest.json"}},"HOTAIRM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOTAIRM1","identifiers":{"aliases":["HOXA-AS1","NCRNA00179","HOXA1-AS1"],"approved_symbol":"HOTAIRM1","ensembl_gene_id":"ENSG00000233429","hgnc_id":"HGNC:37117","ncbi_gene_id":100506311,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOTAIRM1","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA-AS2","identifiers":{"aliases":["HOXA3as"],"approved_symbol":"HOXA-AS2","ensembl_gene_id":"ENSG00000253552","hgnc_id":"HGNC:43745","ncbi_gene_id":285943,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA-AS3","identifiers":{"aliases":["HOXA6as"],"approved_symbol":"HOXA-AS3","ensembl_gene_id":"ENSG00000254369","hgnc_id":"HGNC:43748","ncbi_gene_id":100133311,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HOXA-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA1","identifiers":{"aliases":[],"approved_symbol":"HOXA1","ensembl_gene_id":"ENSG00000105991","hgnc_id":"HGNC:5099","ncbi_gene_id":3198,"previous_symbols":["HOX1F","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HOXA1","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA10","identifiers":{"aliases":[],"approved_symbol":"HOXA10","ensembl_gene_id":"ENSG00000253293","hgnc_id":"HGNC:5100","ncbi_gene_id":3206,"previous_symbols":["HOX1H","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA10","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA10-AS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA10-AS","identifiers":{"aliases":[],"approved_symbol":"HOXA10-AS","ensembl_gene_id":"ENSG00000253187","hgnc_id":"HGNC:40281","ncbi_gene_id":100874323,"previous_symbols":["HOXA-AS4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HOXA10-AS","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA11","identifiers":{"aliases":[],"approved_symbol":"HOXA11","ensembl_gene_id":"ENSG00000005073","hgnc_id":"HGNC:5101","ncbi_gene_id":3207,"previous_symbols":["HOX1I","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA11","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA11-AS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA11-AS","identifiers":{"aliases":["HOXA11-AS1","HOXA11S","HOXA-AS5","NCRNA00076","LncHOXA11"],"approved_symbol":"HOXA11-AS","ensembl_gene_id":"ENSG00000240990","hgnc_id":"HGNC:24957","ncbi_gene_id":221883,"previous_symbols":["HOXA11AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HOXA11-AS","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA13","identifiers":{"aliases":[],"approved_symbol":"HOXA13","ensembl_gene_id":"ENSG00000106031","hgnc_id":"HGNC:5102","ncbi_gene_id":3209,"previous_symbols":["HOX1J","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HOXA13","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA2","identifiers":{"aliases":[],"approved_symbol":"HOXA2","ensembl_gene_id":"ENSG00000105996","hgnc_id":"HGNC:5103","ncbi_gene_id":3199,"previous_symbols":["HOX1K"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA2","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA3","identifiers":{"aliases":[],"approved_symbol":"HOXA3","ensembl_gene_id":"ENSG00000105997","hgnc_id":"HGNC:5104","ncbi_gene_id":3200,"previous_symbols":["HOX1E","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA3","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA4","identifiers":{"aliases":[],"approved_symbol":"HOXA4","ensembl_gene_id":"ENSG00000197576","hgnc_id":"HGNC:5105","ncbi_gene_id":3201,"previous_symbols":["HOX1D","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HOXA4","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA5","identifiers":{"aliases":[],"approved_symbol":"HOXA5","ensembl_gene_id":"ENSG00000106004","hgnc_id":"HGNC:5106","ncbi_gene_id":3202,"previous_symbols":["HOX1C","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA5","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA6","identifiers":{"aliases":[],"approved_symbol":"HOXA6","ensembl_gene_id":"ENSG00000106006","hgnc_id":"HGNC:5107","ncbi_gene_id":3203,"previous_symbols":["HOX1B","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA6","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA7","identifiers":{"aliases":[],"approved_symbol":"HOXA7","ensembl_gene_id":"ENSG00000122592","hgnc_id":"HGNC:5108","ncbi_gene_id":3204,"previous_symbols":["HOX1A","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HOXA7","release_manifest":"api/v1.1/release_manifest.json"}},"HOXA9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXA9","identifiers":{"aliases":[],"approved_symbol":"HOXA9","ensembl_gene_id":"ENSG00000078399","hgnc_id":"HGNC:5109","ncbi_gene_id":3205,"previous_symbols":["HOX1G","HOX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXA9","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB-AS1","identifiers":{"aliases":[],"approved_symbol":"HOXB-AS1","ensembl_gene_id":"ENSG00000230148","hgnc_id":"HGNC:43744","ncbi_gene_id":100874362,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB-AS3","identifiers":{"aliases":[],"approved_symbol":"HOXB-AS3","ensembl_gene_id":"ENSG00000233101","hgnc_id":"HGNC:40283","ncbi_gene_id":404266,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB2","identifiers":{"aliases":[],"approved_symbol":"HOXB2","ensembl_gene_id":"ENSG00000173917","hgnc_id":"HGNC:5113","ncbi_gene_id":3212,"previous_symbols":["HOX2","HOX2H"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB2","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB3","identifiers":{"aliases":[],"approved_symbol":"HOXB3","ensembl_gene_id":"ENSG00000120093","hgnc_id":"HGNC:5114","ncbi_gene_id":3213,"previous_symbols":["HOX2","HOX2G"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HOXB3","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB4","identifiers":{"aliases":[],"approved_symbol":"HOXB4","ensembl_gene_id":"ENSG00000182742","hgnc_id":"HGNC:5115","ncbi_gene_id":3214,"previous_symbols":["HOX2","HOX2F"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB4","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB5","identifiers":{"aliases":[],"approved_symbol":"HOXB5","ensembl_gene_id":"ENSG00000120075","hgnc_id":"HGNC:5116","ncbi_gene_id":3215,"previous_symbols":["HOX2","HOX2A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB5","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB6","identifiers":{"aliases":[],"approved_symbol":"HOXB6","ensembl_gene_id":"ENSG00000108511","hgnc_id":"HGNC:5117","ncbi_gene_id":3216,"previous_symbols":["HOX2","HOX2B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB6","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB7","identifiers":{"aliases":[],"approved_symbol":"HOXB7","ensembl_gene_id":"ENSG00000260027","hgnc_id":"HGNC:5118","ncbi_gene_id":3217,"previous_symbols":["HOX2","HOX2C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXB7","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB8","identifiers":{"aliases":[],"approved_symbol":"HOXB8","ensembl_gene_id":"ENSG00000120068","hgnc_id":"HGNC:5119","ncbi_gene_id":3218,"previous_symbols":["HOX2","HOX2D"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HOXB8","release_manifest":"api/v1.1/release_manifest.json"}},"HOXB9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXB9","identifiers":{"aliases":[],"approved_symbol":"HOXB9","ensembl_gene_id":"ENSG00000170689","hgnc_id":"HGNC:5120","ncbi_gene_id":3219,"previous_symbols":["HOX2E","HOX2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HOXB9","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC-AS1","identifiers":{"aliases":[],"approved_symbol":"HOXC-AS1","ensembl_gene_id":"ENSG00000250451","hgnc_id":"HGNC:43749","ncbi_gene_id":100874363,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC-AS2","identifiers":{"aliases":[],"approved_symbol":"HOXC-AS2","ensembl_gene_id":"ENSG00000250133","hgnc_id":"HGNC:43750","ncbi_gene_id":100874364,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC-AS3","identifiers":{"aliases":[],"approved_symbol":"HOXC-AS3","ensembl_gene_id":"ENSG00000251151","hgnc_id":"HGNC:43751","ncbi_gene_id":100874365,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC10","identifiers":{"aliases":[],"approved_symbol":"HOXC10","ensembl_gene_id":"ENSG00000180818","hgnc_id":"HGNC:5122","ncbi_gene_id":3226,"previous_symbols":["HOX3I"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.12747,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC10","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC11","identifiers":{"aliases":[],"approved_symbol":"HOXC11","ensembl_gene_id":"ENSG00000123388","hgnc_id":"HGNC:5123","ncbi_gene_id":3227,"previous_symbols":["HOX3H"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC11","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC4","identifiers":{"aliases":[],"approved_symbol":"HOXC4","ensembl_gene_id":"ENSG00000198353","hgnc_id":"HGNC:5126","ncbi_gene_id":3221,"previous_symbols":["HOX3","HOX3E"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC4","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC5","identifiers":{"aliases":[],"approved_symbol":"HOXC5","ensembl_gene_id":"ENSG00000172789","hgnc_id":"HGNC:5127","ncbi_gene_id":3222,"previous_symbols":["HOX3D","HOX3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC5","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC6","identifiers":{"aliases":[],"approved_symbol":"HOXC6","ensembl_gene_id":"ENSG00000197757","hgnc_id":"HGNC:5128","ncbi_gene_id":3223,"previous_symbols":["HOX3C","HOX3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC6","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC8","identifiers":{"aliases":[],"approved_symbol":"HOXC8","ensembl_gene_id":"ENSG00000037965","hgnc_id":"HGNC:5129","ncbi_gene_id":3224,"previous_symbols":["HOX3","HOX3A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HOXC8","release_manifest":"api/v1.1/release_manifest.json"}},"HOXC9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXC9","identifiers":{"aliases":[],"approved_symbol":"HOXC9","ensembl_gene_id":"ENSG00000180806","hgnc_id":"HGNC:5130","ncbi_gene_id":3225,"previous_symbols":["HOX3","HOX3B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXC9","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD-AS2","identifiers":{"aliases":[],"approved_symbol":"HOXD-AS2","ensembl_gene_id":"ENSG00000237380","hgnc_id":"HGNC:43756","ncbi_gene_id":100506783,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXD-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD1","identifiers":{"aliases":[],"approved_symbol":"HOXD1","ensembl_gene_id":"ENSG00000128645","hgnc_id":"HGNC:5132","ncbi_gene_id":3231,"previous_symbols":["HOX4","HOX4G"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXD1","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD10","identifiers":{"aliases":[],"approved_symbol":"HOXD10","ensembl_gene_id":"ENSG00000128710","hgnc_id":"HGNC:5133","ncbi_gene_id":3236,"previous_symbols":["HOX4","HOX4D"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HOXD10","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD11","identifiers":{"aliases":[],"approved_symbol":"HOXD11","ensembl_gene_id":"ENSG00000128713","hgnc_id":"HGNC:5134","ncbi_gene_id":3237,"previous_symbols":["HOX4","HOX4F"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HOXD11","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD3","identifiers":{"aliases":[],"approved_symbol":"HOXD3","ensembl_gene_id":"ENSG00000128652","hgnc_id":"HGNC:5137","ncbi_gene_id":3232,"previous_symbols":["HOX4A","HOX4","HOX1D"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXD3","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD4","identifiers":{"aliases":[],"approved_symbol":"HOXD4","ensembl_gene_id":"ENSG00000170166","hgnc_id":"HGNC:5138","ncbi_gene_id":3233,"previous_symbols":["HOX4B","HOX4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HOXD4","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD8","identifiers":{"aliases":[],"approved_symbol":"HOXD8","ensembl_gene_id":"ENSG00000175879","hgnc_id":"HGNC:5139","ncbi_gene_id":3234,"previous_symbols":["HOX4","HOX4E"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXD8","release_manifest":"api/v1.1/release_manifest.json"}},"HOXD9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HOXD9","identifiers":{"aliases":[],"approved_symbol":"HOXD9","ensembl_gene_id":"ENSG00000128709","hgnc_id":"HGNC:5140","ncbi_gene_id":3235,"previous_symbols":["HOX4C","HOX4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HOXD9","release_manifest":"api/v1.1/release_manifest.json"}},"HP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HP","identifiers":{"aliases":[],"approved_symbol":"HP","ensembl_gene_id":"ENSG00000257017","hgnc_id":"HGNC:5141","ncbi_gene_id":3240,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HP","release_manifest":"api/v1.1/release_manifest.json"}},"HP1BP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HP1BP3","identifiers":{"aliases":["HP1-BP74"],"approved_symbol":"HP1BP3","ensembl_gene_id":"ENSG00000127483","hgnc_id":"HGNC:24973","ncbi_gene_id":50809,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HP1BP3","release_manifest":"api/v1.1/release_manifest.json"}},"HPCA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPCA","identifiers":{"aliases":[],"approved_symbol":"HPCA","ensembl_gene_id":"ENSG00000121905","hgnc_id":"HGNC:5144","ncbi_gene_id":3208,"previous_symbols":["DYT2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPCA","release_manifest":"api/v1.1/release_manifest.json"}},"HPCAL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPCAL1","identifiers":{"aliases":["BDR1","HLP2","VILIP-3"],"approved_symbol":"HPCAL1","ensembl_gene_id":"ENSG00000115756","hgnc_id":"HGNC:5145","ncbi_gene_id":3241,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPCAL1","release_manifest":"api/v1.1/release_manifest.json"}},"HPCAL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPCAL4","identifiers":{"aliases":["HLP4","DKFZp761G122"],"approved_symbol":"HPCAL4","ensembl_gene_id":"ENSG00000116983","hgnc_id":"HGNC:18212","ncbi_gene_id":51440,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HPCAL4","release_manifest":"api/v1.1/release_manifest.json"}},"HPD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPD","identifiers":{"aliases":["4-HPPD","4HPPD","GLOD3","HPPD"],"approved_symbol":"HPD","ensembl_gene_id":"ENSG00000158104","hgnc_id":"HGNC:5147","ncbi_gene_id":3242,"previous_symbols":["PPD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPD","release_manifest":"api/v1.1/release_manifest.json"}},"HPDL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPDL","identifiers":{"aliases":["MGC15668","4-HPPD-L"],"approved_symbol":"HPDL","ensembl_gene_id":"ENSG00000186603","hgnc_id":"HGNC:28242","ncbi_gene_id":84842,"previous_symbols":["GLOXD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HPDL","release_manifest":"api/v1.1/release_manifest.json"}},"HPF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPF1","identifiers":{"aliases":["FLJ20534"],"approved_symbol":"HPF1","ensembl_gene_id":"ENSG00000056050","hgnc_id":"HGNC:26051","ncbi_gene_id":54969,"previous_symbols":["C4orf27"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HPF1","release_manifest":"api/v1.1/release_manifest.json"}},"HPGD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPGD","identifiers":{"aliases":["SDR36C1"],"approved_symbol":"HPGD","ensembl_gene_id":"ENSG00000164120","hgnc_id":"HGNC:5154","ncbi_gene_id":3248,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPGD","release_manifest":"api/v1.1/release_manifest.json"}},"HPGDS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPGDS","identifiers":{"aliases":["GSTS","PGDS","H-PGDS","PGD2","GSTS1-1","GSTS1"],"approved_symbol":"HPGDS","ensembl_gene_id":"ENSG00000163106","hgnc_id":"HGNC:17890","ncbi_gene_id":27306,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HPGDS","release_manifest":"api/v1.1/release_manifest.json"}},"HPN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPN","identifiers":{"aliases":["TMPRSS1"],"approved_symbol":"HPN","ensembl_gene_id":"ENSG00000105707","hgnc_id":"HGNC:5155","ncbi_gene_id":3249,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPN","release_manifest":"api/v1.1/release_manifest.json"}},"HPN-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPN-AS1","identifiers":{"aliases":[],"approved_symbol":"HPN-AS1","ensembl_gene_id":"ENSG00000227392","hgnc_id":"HGNC:47041","ncbi_gene_id":100128675,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HPN-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HPR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPR","identifiers":{"aliases":[],"approved_symbol":"HPR","ensembl_gene_id":"ENSG00000261701","hgnc_id":"HGNC:5156","ncbi_gene_id":3250,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HPR","release_manifest":"api/v1.1/release_manifest.json"}},"HPRT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPRT1","identifiers":{"aliases":["HGPRT"],"approved_symbol":"HPRT1","ensembl_gene_id":"ENSG00000165704","hgnc_id":"HGNC:5157","ncbi_gene_id":3251,"previous_symbols":["HPRT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPRT1","release_manifest":"api/v1.1/release_manifest.json"}},"HPS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPS1","identifiers":{"aliases":["BLOC3S1"],"approved_symbol":"HPS1","ensembl_gene_id":"ENSG00000107521","hgnc_id":"HGNC:5163","ncbi_gene_id":3257,"previous_symbols":["HPS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPS1","release_manifest":"api/v1.1/release_manifest.json"}},"HPS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPS3","identifiers":{"aliases":["SUTAL","BLOC2S1"],"approved_symbol":"HPS3","ensembl_gene_id":"ENSG00000163755","hgnc_id":"HGNC:15597","ncbi_gene_id":84343,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPS3","release_manifest":"api/v1.1/release_manifest.json"}},"HPS4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPS4","identifiers":{"aliases":["KIAA1667","LE","BLOC3S2"],"approved_symbol":"HPS4","ensembl_gene_id":"ENSG00000100099","hgnc_id":"HGNC:15844","ncbi_gene_id":89781,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPS4","release_manifest":"api/v1.1/release_manifest.json"}},"HPS5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPS5","identifiers":{"aliases":["BLOC2S2","AIBP63","RU2"],"approved_symbol":"HPS5","ensembl_gene_id":"ENSG00000110756","hgnc_id":"HGNC:17022","ncbi_gene_id":11234,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPS5","release_manifest":"api/v1.1/release_manifest.json"}},"HPS6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPS6","identifiers":{"aliases":["FLJ22501","BLOC2S3"],"approved_symbol":"HPS6","ensembl_gene_id":"ENSG00000166189","hgnc_id":"HGNC:18817","ncbi_gene_id":79803,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPS6","release_manifest":"api/v1.1/release_manifest.json"}},"HPSE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPSE","identifiers":{"aliases":["HPA","HSE1","HPSE1"],"approved_symbol":"HPSE","ensembl_gene_id":"ENSG00000173083","hgnc_id":"HGNC:5164","ncbi_gene_id":10855,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HPSE","release_manifest":"api/v1.1/release_manifest.json"}},"HPSE2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPSE2","identifiers":{"aliases":["HPA2","HPR2"],"approved_symbol":"HPSE2","ensembl_gene_id":"ENSG00000172987","hgnc_id":"HGNC:18374","ncbi_gene_id":60495,"previous_symbols":["UFS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPSE2","release_manifest":"api/v1.1/release_manifest.json"}},"HPX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPX","identifiers":{"aliases":[],"approved_symbol":"HPX","ensembl_gene_id":"ENSG00000110169","hgnc_id":"HGNC:5171","ncbi_gene_id":3263,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPX","release_manifest":"api/v1.1/release_manifest.json"}},"HPYR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HPYR1","identifiers":{"aliases":["HPRG1","NCRNA00027","LINC00027"],"approved_symbol":"HPYR1","ensembl_gene_id":"ENSG00000253521","hgnc_id":"HGNC:16071","ncbi_gene_id":93668,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HPYR1","release_manifest":"api/v1.1/release_manifest.json"}},"HR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HR","identifiers":{"aliases":["KDM3D","AU"],"approved_symbol":"HR","ensembl_gene_id":"ENSG00000168453","hgnc_id":"HGNC:5172","ncbi_gene_id":55806,"previous_symbols":["ALUNC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HR","release_manifest":"api/v1.1/release_manifest.json"}},"HRAS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRAS","identifiers":{"aliases":[],"approved_symbol":"HRAS","ensembl_gene_id":"ENSG00000174775","hgnc_id":"HGNC:5173","ncbi_gene_id":3265,"previous_symbols":["HRAS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HRAS","release_manifest":"api/v1.1/release_manifest.json"}},"HRC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRC","identifiers":{"aliases":["MGC133236"],"approved_symbol":"HRC","ensembl_gene_id":"ENSG00000130528","hgnc_id":"HGNC:5178","ncbi_gene_id":3270,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HRC","release_manifest":"api/v1.1/release_manifest.json"}},"HRCT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRCT1","identifiers":{"aliases":["LGLL338","PRO537","UNQ338"],"approved_symbol":"HRCT1","ensembl_gene_id":"ENSG00000196196","hgnc_id":"HGNC:33872","ncbi_gene_id":646962,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HRCT1","release_manifest":"api/v1.1/release_manifest.json"}},"HRH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRH1","identifiers":{"aliases":[],"approved_symbol":"HRH1","ensembl_gene_id":"ENSG00000196639","hgnc_id":"HGNC:5182","ncbi_gene_id":3269,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HRH1","release_manifest":"api/v1.1/release_manifest.json"}},"HRH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRH2","identifiers":{"aliases":[],"approved_symbol":"HRH2","ensembl_gene_id":"ENSG00000113749","hgnc_id":"HGNC:5183","ncbi_gene_id":3274,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HRH2","release_manifest":"api/v1.1/release_manifest.json"}},"HRH4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRH4","identifiers":{"aliases":["H4R","HH4R","AXOR35","GPCR105","GPRv53"],"approved_symbol":"HRH4","ensembl_gene_id":"ENSG00000134489","hgnc_id":"HGNC:17383","ncbi_gene_id":59340,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HRH4","release_manifest":"api/v1.1/release_manifest.json"}},"HRK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRK","identifiers":{"aliases":["DP5"],"approved_symbol":"HRK","ensembl_gene_id":"ENSG00000135116","hgnc_id":"HGNC:5185","ncbi_gene_id":8739,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HRK","release_manifest":"api/v1.1/release_manifest.json"}},"HRNR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HRNR","identifiers":{"aliases":["S100a18","S100A16","FLG3"],"approved_symbol":"HRNR","ensembl_gene_id":"ENSG00000197915","hgnc_id":"HGNC:20846","ncbi_gene_id":388697,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HRNR","release_manifest":"api/v1.1/release_manifest.json"}},"HS1BP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS1BP3","identifiers":{"aliases":["HS1-BP3","FLJ14249"],"approved_symbol":"HS1BP3","ensembl_gene_id":"ENSG00000118960","hgnc_id":"HGNC:24979","ncbi_gene_id":64342,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS1BP3","release_manifest":"api/v1.1/release_manifest.json"}},"HS2ST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS2ST1","identifiers":{"aliases":["KIAA0448"],"approved_symbol":"HS2ST1","ensembl_gene_id":"ENSG00000153936","hgnc_id":"HGNC:5193","ncbi_gene_id":9653,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS2ST1","release_manifest":"api/v1.1/release_manifest.json"}},"HS3ST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS3ST1","identifiers":{"aliases":["3OST1"],"approved_symbol":"HS3ST1","ensembl_gene_id":"ENSG00000002587","hgnc_id":"HGNC:5194","ncbi_gene_id":9957,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS3ST1","release_manifest":"api/v1.1/release_manifest.json"}},"HS3ST2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS3ST2","identifiers":{"aliases":["3OST2"],"approved_symbol":"HS3ST2","ensembl_gene_id":"ENSG00000122254","hgnc_id":"HGNC:5195","ncbi_gene_id":9956,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS3ST2","release_manifest":"api/v1.1/release_manifest.json"}},"HS3ST3A1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS3ST3A1","identifiers":{"aliases":["3OST3A1","30ST3A1"],"approved_symbol":"HS3ST3A1","ensembl_gene_id":"ENSG00000153976","hgnc_id":"HGNC:5196","ncbi_gene_id":9955,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS3ST3A1","release_manifest":"api/v1.1/release_manifest.json"}},"HS3ST3B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS3ST3B1","identifiers":{"aliases":["3OST3B1","30ST3B1"],"approved_symbol":"HS3ST3B1","ensembl_gene_id":"ENSG00000125430","hgnc_id":"HGNC:5198","ncbi_gene_id":9953,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HS3ST3B1","release_manifest":"api/v1.1/release_manifest.json"}},"HS3ST4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS3ST4","identifiers":{"aliases":["3OST4"],"approved_symbol":"HS3ST4","ensembl_gene_id":"ENSG00000182601","hgnc_id":"HGNC:5200","ncbi_gene_id":9951,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HS3ST4","release_manifest":"api/v1.1/release_manifest.json"}},"HS3ST5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS3ST5","identifiers":{"aliases":["3-OST-5"],"approved_symbol":"HS3ST5","ensembl_gene_id":"ENSG00000249853","hgnc_id":"HGNC:19419","ncbi_gene_id":222537,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS3ST5","release_manifest":"api/v1.1/release_manifest.json"}},"HS6ST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS6ST1","identifiers":{"aliases":[],"approved_symbol":"HS6ST1","ensembl_gene_id":"ENSG00000136720","hgnc_id":"HGNC:5201","ncbi_gene_id":9394,"previous_symbols":["HS6ST"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS6ST1","release_manifest":"api/v1.1/release_manifest.json"}},"HS6ST2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS6ST2","identifiers":{"aliases":["HS6ST-2"],"approved_symbol":"HS6ST2","ensembl_gene_id":"ENSG00000171004","hgnc_id":"HGNC:19133","ncbi_gene_id":90161,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HS6ST2","release_manifest":"api/v1.1/release_manifest.json"}},"HS6ST3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HS6ST3","identifiers":{"aliases":[],"approved_symbol":"HS6ST3","ensembl_gene_id":"ENSG00000185352","hgnc_id":"HGNC:19134","ncbi_gene_id":266722,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HS6ST3","release_manifest":"api/v1.1/release_manifest.json"}},"HSBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSBP1","identifiers":{"aliases":[],"approved_symbol":"HSBP1","ensembl_gene_id":"ENSG00000230989","hgnc_id":"HGNC:5203","ncbi_gene_id":3281,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSBP1","release_manifest":"api/v1.1/release_manifest.json"}},"HSBP1L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSBP1L1","identifiers":{"aliases":["FLJ10967","MGC189743"],"approved_symbol":"HSBP1L1","ensembl_gene_id":"ENSG00000226742","hgnc_id":"HGNC:37243","ncbi_gene_id":440498,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSBP1L1","release_manifest":"api/v1.1/release_manifest.json"}},"HSCB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSCB","identifiers":{"aliases":["HSC20","DNAJC20","Jac1"],"approved_symbol":"HSCB","ensembl_gene_id":"ENSG00000100209","hgnc_id":"HGNC:28913","ncbi_gene_id":150274,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSCB","release_manifest":"api/v1.1/release_manifest.json"}},"HSD11B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD11B1","identifiers":{"aliases":["SDR26C1"],"approved_symbol":"HSD11B1","ensembl_gene_id":"ENSG00000117594","hgnc_id":"HGNC:5208","ncbi_gene_id":3290,"previous_symbols":["HSD11B","HSD11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD11B1","release_manifest":"api/v1.1/release_manifest.json"}},"HSD11B1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD11B1-AS1","identifiers":{"aliases":[],"approved_symbol":"HSD11B1-AS1","ensembl_gene_id":"ENSG00000227591","hgnc_id":"HGNC:54053","ncbi_gene_id":101930114,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD11B1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HSD11B1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD11B1L","identifiers":{"aliases":["SCDR10","SDR26C2","HSD1L"],"approved_symbol":"HSD11B1L","ensembl_gene_id":"ENSG00000167733","hgnc_id":"HGNC:30419","ncbi_gene_id":374875,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD11B1L","release_manifest":"api/v1.1/release_manifest.json"}},"HSD11B2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD11B2","identifiers":{"aliases":["SDR9C3"],"approved_symbol":"HSD11B2","ensembl_gene_id":"ENSG00000176387","hgnc_id":"HGNC:5209","ncbi_gene_id":3291,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD11B2","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B1","identifiers":{"aliases":["HSD17","MGC138140","SDR28C1"],"approved_symbol":"HSD17B1","ensembl_gene_id":"ENSG00000108786","hgnc_id":"HGNC:5210","ncbi_gene_id":3292,"previous_symbols":["EDHB17","EDH17B2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B1","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B10","identifiers":{"aliases":["ERAB","MHBD","17b-HSD10","ABAD","SDR5C1","MRPP2","CAMR"],"approved_symbol":"HSD17B10","ensembl_gene_id":"ENSG00000072506","hgnc_id":"HGNC:4800","ncbi_gene_id":3028,"previous_symbols":["HADH2","MRXS10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B10","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B11","identifiers":{"aliases":["RetSDR2","17-BETA-HSD11","17-BETA-HSDXI","PAN1B","SDR16C2"],"approved_symbol":"HSD17B11","ensembl_gene_id":"ENSG00000198189","hgnc_id":"HGNC:22960","ncbi_gene_id":51170,"previous_symbols":["DHRS8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B11","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B12","identifiers":{"aliases":["KAR","SDR12C1"],"approved_symbol":"HSD17B12","ensembl_gene_id":"ENSG00000149084","hgnc_id":"HGNC:18646","ncbi_gene_id":51144,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B12","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B13","identifiers":{"aliases":["SCDR9","SDR16C3"],"approved_symbol":"HSD17B13","ensembl_gene_id":"ENSG00000170509","hgnc_id":"HGNC:18685","ncbi_gene_id":345275,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B13","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B14","identifiers":{"aliases":["retSDR3","SDR47C1"],"approved_symbol":"HSD17B14","ensembl_gene_id":"ENSG00000087076","hgnc_id":"HGNC:23238","ncbi_gene_id":51171,"previous_symbols":["DHRS10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B14","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B3","identifiers":{"aliases":["SDR12C2"],"approved_symbol":"HSD17B3","ensembl_gene_id":"ENSG00000130948","hgnc_id":"HGNC:5212","ncbi_gene_id":3293,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B3","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B4","identifiers":{"aliases":["MFE-2","DBP","SDR8C1"],"approved_symbol":"HSD17B4","ensembl_gene_id":"ENSG00000133835","hgnc_id":"HGNC:5213","ncbi_gene_id":3295,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B4","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B6","identifiers":{"aliases":["HSE","RODH","SDR9C6"],"approved_symbol":"HSD17B6","ensembl_gene_id":"ENSG00000025423","hgnc_id":"HGNC:23316","ncbi_gene_id":8630,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B6","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B7","identifiers":{"aliases":["PRAP","SDR37C1"],"approved_symbol":"HSD17B7","ensembl_gene_id":"ENSG00000132196","hgnc_id":"HGNC:5215","ncbi_gene_id":51478,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B7","release_manifest":"api/v1.1/release_manifest.json"}},"HSD17B8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD17B8","identifiers":{"aliases":["HKE6","D6S2245E","RING2","KE6","H2-KE6","SDR30C1"],"approved_symbol":"HSD17B8","ensembl_gene_id":"ENSG00000204228","hgnc_id":"HGNC:3554","ncbi_gene_id":7923,"previous_symbols":["FABGL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD17B8","release_manifest":"api/v1.1/release_manifest.json"}},"HSD3B7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSD3B7","identifiers":{"aliases":["C(27)-3BETA-HSD","SDR11E3"],"approved_symbol":"HSD3B7","ensembl_gene_id":"ENSG00000099377","hgnc_id":"HGNC:18324","ncbi_gene_id":80270,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSD3B7","release_manifest":"api/v1.1/release_manifest.json"}},"HSDL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSDL1","identifiers":{"aliases":["SDR12C3"],"approved_symbol":"HSDL1","ensembl_gene_id":"ENSG00000103160","hgnc_id":"HGNC:16475","ncbi_gene_id":83693,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSDL1","release_manifest":"api/v1.1/release_manifest.json"}},"HSDL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSDL2","identifiers":{"aliases":["SDR13C1"],"approved_symbol":"HSDL2","ensembl_gene_id":"ENSG00000119471","hgnc_id":"HGNC:18572","ncbi_gene_id":84263,"previous_symbols":["C9orf99"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSDL2","release_manifest":"api/v1.1/release_manifest.json"}},"HSF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSF1","identifiers":{"aliases":["HSTF1"],"approved_symbol":"HSF1","ensembl_gene_id":"ENSG00000185122","hgnc_id":"HGNC:5224","ncbi_gene_id":3297,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.035523,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSF1","release_manifest":"api/v1.1/release_manifest.json"}},"HSF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSF2","identifiers":{"aliases":[],"approved_symbol":"HSF2","ensembl_gene_id":"ENSG00000025156","hgnc_id":"HGNC:5225","ncbi_gene_id":3298,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSF2","release_manifest":"api/v1.1/release_manifest.json"}},"HSF2BP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSF2BP","identifiers":{"aliases":["MEILB2"],"approved_symbol":"HSF2BP","ensembl_gene_id":"ENSG00000160207","hgnc_id":"HGNC:5226","ncbi_gene_id":11077,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSF2BP","release_manifest":"api/v1.1/release_manifest.json"}},"HSF4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSF4","identifiers":{"aliases":[],"approved_symbol":"HSF4","ensembl_gene_id":"ENSG00000102878","hgnc_id":"HGNC:5227","ncbi_gene_id":3299,"previous_symbols":["CTM"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSF4","release_manifest":"api/v1.1/release_manifest.json"}},"HSF5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSF5","identifiers":{"aliases":["FLJ40311"],"approved_symbol":"HSF5","ensembl_gene_id":"ENSG00000176160","hgnc_id":"HGNC:26862","ncbi_gene_id":124535,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSF5","release_manifest":"api/v1.1/release_manifest.json"}},"HSH2D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSH2D","identifiers":{"aliases":["ALX","HSH2","FLJ14886"],"approved_symbol":"HSH2D","ensembl_gene_id":"ENSG00000196684","hgnc_id":"HGNC:24920","ncbi_gene_id":84941,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSH2D","release_manifest":"api/v1.1/release_manifest.json"}},"HSP90AA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSP90AA1","identifiers":{"aliases":["Hsp89","Hsp90","FLJ31884","HSP90N"],"approved_symbol":"HSP90AA1","ensembl_gene_id":"ENSG00000080824","hgnc_id":"HGNC:5253","ncbi_gene_id":3320,"previous_symbols":["HSPC1","HSPCA","HSPCAL4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSP90AA1","release_manifest":"api/v1.1/release_manifest.json"}},"HSP90AB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSP90AB1","identifiers":{"aliases":[],"approved_symbol":"HSP90AB1","ensembl_gene_id":"ENSG00000096384","hgnc_id":"HGNC:5258","ncbi_gene_id":3326,"previous_symbols":["HSPC2","HSPCB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSP90AB1","release_manifest":"api/v1.1/release_manifest.json"}},"HSP90B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSP90B1","identifiers":{"aliases":["GP96","GRP94"],"approved_symbol":"HSP90B1","ensembl_gene_id":"ENSG00000166598","hgnc_id":"HGNC:12028","ncbi_gene_id":7184,"previous_symbols":["TRA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSP90B1","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA12A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA12A","identifiers":{"aliases":["FLJ13874","KIAA0417"],"approved_symbol":"HSPA12A","ensembl_gene_id":"ENSG00000165868","hgnc_id":"HGNC:19022","ncbi_gene_id":259217,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA12A","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA12B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA12B","identifiers":{"aliases":["dJ1009E24.2"],"approved_symbol":"HSPA12B","ensembl_gene_id":"ENSG00000132622","hgnc_id":"HGNC:16193","ncbi_gene_id":116835,"previous_symbols":["C20orf60"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA12B","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA13","identifiers":{"aliases":[],"approved_symbol":"HSPA13","ensembl_gene_id":"ENSG00000155304","hgnc_id":"HGNC:11375","ncbi_gene_id":6782,"previous_symbols":["STCH"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA13","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA14","identifiers":{"aliases":["HSP70-4","HSP70L1"],"approved_symbol":"HSPA14","ensembl_gene_id":"ENSG00000187522","hgnc_id":"HGNC:29526","ncbi_gene_id":51182,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":true,"effect_size":1.1322,"fdr":0.055718,"context":"GSE293514_myoblast_fusion_screen","interpretation":"screen_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA14","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA1A","identifiers":{"aliases":["HSP70-1"],"approved_symbol":"HSPA1A","ensembl_gene_id":"ENSG00000204389","hgnc_id":"HGNC:5232","ncbi_gene_id":3303,"previous_symbols":["HSPA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA1A","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA1B","identifiers":{"aliases":["HSP70-2"],"approved_symbol":"HSPA1B","ensembl_gene_id":"ENSG00000204388","hgnc_id":"HGNC:5233","ncbi_gene_id":3304,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA1B","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA1L","identifiers":{"aliases":["HSP70-HOM","hum70t"],"approved_symbol":"HSPA1L","ensembl_gene_id":"ENSG00000204390","hgnc_id":"HGNC:5234","ncbi_gene_id":3305,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA1L","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA2","identifiers":{"aliases":[],"approved_symbol":"HSPA2","ensembl_gene_id":"ENSG00000126803","hgnc_id":"HGNC:5235","ncbi_gene_id":3306,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA2","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA4","identifiers":{"aliases":["HS24/P52","HSPH2"],"approved_symbol":"HSPA4","ensembl_gene_id":"ENSG00000170606","hgnc_id":"HGNC:5237","ncbi_gene_id":3308,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA4","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA4L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA4L","identifiers":{"aliases":["APG-1","Osp94","HSPH3"],"approved_symbol":"HSPA4L","ensembl_gene_id":"ENSG00000164070","hgnc_id":"HGNC:17041","ncbi_gene_id":22824,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA4L","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA5","identifiers":{"aliases":["BiP"],"approved_symbol":"HSPA5","ensembl_gene_id":"ENSG00000044574","hgnc_id":"HGNC:5238","ncbi_gene_id":3309,"previous_symbols":["GRP78"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA5","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA6","identifiers":{"aliases":["HSP70B'"],"approved_symbol":"HSPA6","ensembl_gene_id":"ENSG00000173110","hgnc_id":"HGNC:5239","ncbi_gene_id":3310,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA6","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA8","identifiers":{"aliases":["HSC71","HSC70","HSP73"],"approved_symbol":"HSPA8","ensembl_gene_id":"ENSG00000109971","hgnc_id":"HGNC:5241","ncbi_gene_id":3312,"previous_symbols":["HSPA10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA8","release_manifest":"api/v1.1/release_manifest.json"}},"HSPA9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPA9","identifiers":{"aliases":["GRP75","PBP74","mot-2","mthsp75"],"approved_symbol":"HSPA9","ensembl_gene_id":"ENSG00000113013","hgnc_id":"HGNC:5244","ncbi_gene_id":3313,"previous_symbols":["HSPA9B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPA9","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB1","identifiers":{"aliases":["HSP27","HSP28","Hs.76067","Hsp25","CMT2F"],"approved_symbol":"HSPB1","ensembl_gene_id":"ENSG00000106211","hgnc_id":"HGNC:5246","ncbi_gene_id":3315,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/HSPB1","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB11","identifiers":{"approved_symbol":"HSPB11","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HSPB11","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB2","identifiers":{"aliases":["Hs.78846","MKBP"],"approved_symbol":"HSPB2","ensembl_gene_id":"ENSG00000170276","hgnc_id":"HGNC:5247","ncbi_gene_id":3316,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPB2","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB3","identifiers":{"aliases":["HSPL27"],"approved_symbol":"HSPB3","ensembl_gene_id":"ENSG00000169271","hgnc_id":"HGNC:5248","ncbi_gene_id":8988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HSPB3","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB6","identifiers":{"aliases":["FLJ32389","Hsp20","PPP1R91"],"approved_symbol":"HSPB6","ensembl_gene_id":"ENSG00000004776","hgnc_id":"HGNC:26511","ncbi_gene_id":126393,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPB6","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB7","identifiers":{"aliases":["cvHSP"],"approved_symbol":"HSPB7","ensembl_gene_id":"ENSG00000173641","hgnc_id":"HGNC:5249","ncbi_gene_id":27129,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPB7","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB8","identifiers":{"aliases":["H11","E2IG1","HSP22","CMT2L"],"approved_symbol":"HSPB8","ensembl_gene_id":"ENSG00000152137","hgnc_id":"HGNC:30171","ncbi_gene_id":26353,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/HSPB8","release_manifest":"api/v1.1/release_manifest.json"}},"HSPB9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPB9","identifiers":{"aliases":["CT51"],"approved_symbol":"HSPB9","ensembl_gene_id":"ENSG00000260325","hgnc_id":"HGNC:30589","ncbi_gene_id":94086,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HSPB9","release_manifest":"api/v1.1/release_manifest.json"}},"HSPBAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPBAP1","identifiers":{"aliases":["FLJ22623","PASS1"],"approved_symbol":"HSPBAP1","ensembl_gene_id":"ENSG00000169087","hgnc_id":"HGNC:16389","ncbi_gene_id":79663,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPBAP1","release_manifest":"api/v1.1/release_manifest.json"}},"HSPBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPBP1","identifiers":{"aliases":["FES1"],"approved_symbol":"HSPBP1","ensembl_gene_id":"ENSG00000133265","hgnc_id":"HGNC:24989","ncbi_gene_id":23640,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPBP1","release_manifest":"api/v1.1/release_manifest.json"}},"HSPD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPD1","identifiers":{"aliases":["GroEL","HSP60"],"approved_symbol":"HSPD1","ensembl_gene_id":"ENSG00000144381","hgnc_id":"HGNC:5261","ncbi_gene_id":3329,"previous_symbols":["SPG13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPD1","release_manifest":"api/v1.1/release_manifest.json"}},"HSPE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPE1","identifiers":{"aliases":["CPN10","GroES","HSP10","EPF"],"approved_symbol":"HSPE1","ensembl_gene_id":"ENSG00000115541","hgnc_id":"HGNC:5269","ncbi_gene_id":3336,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPE1","release_manifest":"api/v1.1/release_manifest.json"}},"HSPG2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPG2","identifiers":{"aliases":["perlecan","PRCAN"],"approved_symbol":"HSPG2","ensembl_gene_id":"ENSG00000142798","hgnc_id":"HGNC:5273","ncbi_gene_id":3339,"previous_symbols":["SJS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPG2","release_manifest":"api/v1.1/release_manifest.json"}},"HSPH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HSPH1","identifiers":{"aliases":["HSP105B","KIAA0201","HSP105A","NY-CO-25"],"approved_symbol":"HSPH1","ensembl_gene_id":"ENSG00000120694","hgnc_id":"HGNC:16969","ncbi_gene_id":10808,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HSPH1","release_manifest":"api/v1.1/release_manifest.json"}},"HTATIP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTATIP2","identifiers":{"aliases":["TIP30","CC3","FLJ26963","SDR44U1"],"approved_symbol":"HTATIP2","ensembl_gene_id":"ENSG00000109854","hgnc_id":"HGNC:16637","ncbi_gene_id":10553,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTATIP2","release_manifest":"api/v1.1/release_manifest.json"}},"HTATSF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTATSF1","identifiers":{"aliases":["TAT-SF1"],"approved_symbol":"HTATSF1","ensembl_gene_id":"ENSG00000102241","hgnc_id":"HGNC:5276","ncbi_gene_id":27336,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTATSF1","release_manifest":"api/v1.1/release_manifest.json"}},"HTR1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR1B","identifiers":{"aliases":["S12","5-HT1B","HTR1D2","5-HT1DB"],"approved_symbol":"HTR1B","ensembl_gene_id":"ENSG00000135312","hgnc_id":"HGNC:5287","ncbi_gene_id":3351,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HTR1B","release_manifest":"api/v1.1/release_manifest.json"}},"HTR1D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR1D","identifiers":{"aliases":["RDC4","HT1DA","5-HT1D"],"approved_symbol":"HTR1D","ensembl_gene_id":"ENSG00000179546","hgnc_id":"HGNC:5289","ncbi_gene_id":3352,"previous_symbols":["HTRL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/HTR1D","release_manifest":"api/v1.1/release_manifest.json"}},"HTR1F":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR1F","identifiers":{"aliases":["HTR1EL","5-HT1F"],"approved_symbol":"HTR1F","ensembl_gene_id":"ENSG00000179097","hgnc_id":"HGNC:5292","ncbi_gene_id":3355,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTR1F","release_manifest":"api/v1.1/release_manifest.json"}},"HTR2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR2A","identifiers":{"aliases":["5-HT2A"],"approved_symbol":"HTR2A","ensembl_gene_id":"ENSG00000102468","hgnc_id":"HGNC:5293","ncbi_gene_id":3356,"previous_symbols":["HTR2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTR2A","release_manifest":"api/v1.1/release_manifest.json"}},"HTR2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR2B","identifiers":{"aliases":["5-HT(2B)","5-HT2B"],"approved_symbol":"HTR2B","ensembl_gene_id":"ENSG00000135914","hgnc_id":"HGNC:5294","ncbi_gene_id":3357,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTR2B","release_manifest":"api/v1.1/release_manifest.json"}},"HTR2C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR2C","identifiers":{"aliases":["5-HT2C","5HTR2C"],"approved_symbol":"HTR2C","ensembl_gene_id":"ENSG00000147246","hgnc_id":"HGNC:5295","ncbi_gene_id":3358,"previous_symbols":["HTR1C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HTR2C","release_manifest":"api/v1.1/release_manifest.json"}},"HTR4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR4","identifiers":{"aliases":["5-HT4"],"approved_symbol":"HTR4","ensembl_gene_id":"ENSG00000164270","hgnc_id":"HGNC:5299","ncbi_gene_id":3360,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTR4","release_manifest":"api/v1.1/release_manifest.json"}},"HTR5A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR5A","identifiers":{"aliases":["5-HT5A"],"approved_symbol":"HTR5A","ensembl_gene_id":"ENSG00000157219","hgnc_id":"HGNC:5300","ncbi_gene_id":3361,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HTR5A","release_manifest":"api/v1.1/release_manifest.json"}},"HTR6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR6","identifiers":{"aliases":["5-HT6","5-HT6R"],"approved_symbol":"HTR6","ensembl_gene_id":"ENSG00000158748","hgnc_id":"HGNC:5301","ncbi_gene_id":3362,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HTR6","release_manifest":"api/v1.1/release_manifest.json"}},"HTR7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTR7","identifiers":{"aliases":["5-HT7"],"approved_symbol":"HTR7","ensembl_gene_id":"ENSG00000148680","hgnc_id":"HGNC:5302","ncbi_gene_id":3363,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTR7","release_manifest":"api/v1.1/release_manifest.json"}},"HTRA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTRA1","identifiers":{"aliases":["HtrA","IGFBP5-protease","ARMD7"],"approved_symbol":"HTRA1","ensembl_gene_id":"ENSG00000166033","hgnc_id":"HGNC:9476","ncbi_gene_id":5654,"previous_symbols":["PRSS11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTRA1","release_manifest":"api/v1.1/release_manifest.json"}},"HTRA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTRA2","identifiers":{"aliases":["OMI","PARK13"],"approved_symbol":"HTRA2","ensembl_gene_id":"ENSG00000115317","hgnc_id":"HGNC:14348","ncbi_gene_id":27429,"previous_symbols":["PRSS25"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTRA2","release_manifest":"api/v1.1/release_manifest.json"}},"HTRA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTRA3","identifiers":{"aliases":["Tasp","Prsp"],"approved_symbol":"HTRA3","ensembl_gene_id":"ENSG00000170801","hgnc_id":"HGNC:30406","ncbi_gene_id":94031,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/HTRA3","release_manifest":"api/v1.1/release_manifest.json"}},"HTRA4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTRA4","identifiers":{"aliases":["FLJ90724"],"approved_symbol":"HTRA4","ensembl_gene_id":"ENSG00000169495","hgnc_id":"HGNC:26909","ncbi_gene_id":203100,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTRA4","release_manifest":"api/v1.1/release_manifest.json"}},"HTT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTT","identifiers":{"aliases":["IT15"],"approved_symbol":"HTT","ensembl_gene_id":"ENSG00000197386","hgnc_id":"HGNC:4851","ncbi_gene_id":3064,"previous_symbols":["HD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HTT","release_manifest":"api/v1.1/release_manifest.json"}},"HTT-AS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HTT-AS","identifiers":{"aliases":["HTTAS"],"approved_symbol":"HTT-AS","ensembl_gene_id":"ENSG00000251075","hgnc_id":"HGNC:37118","ncbi_gene_id":100750326,"previous_symbols":["HTT-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/HTT-AS","release_manifest":"api/v1.1/release_manifest.json"}},"HULC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HULC","identifiers":{"aliases":["NCRNA00078","LINC00078","HCCAT1"],"approved_symbol":"HULC","ensembl_gene_id":"ENSG00000285219","hgnc_id":"HGNC:34232","ncbi_gene_id":728655,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HULC","release_manifest":"api/v1.1/release_manifest.json"}},"HUNK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HUNK","identifiers":{"aliases":[],"approved_symbol":"HUNK","ensembl_gene_id":"ENSG00000142149","hgnc_id":"HGNC:13326","ncbi_gene_id":30811,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HUNK","release_manifest":"api/v1.1/release_manifest.json"}},"HUS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HUS1","identifiers":{"aliases":[],"approved_symbol":"HUS1","ensembl_gene_id":"ENSG00000136273","hgnc_id":"HGNC:5309","ncbi_gene_id":3364,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.20499,"fdr":0.422867,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HUS1","release_manifest":"api/v1.1/release_manifest.json"}},"HUS1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HUS1B","identifiers":{"aliases":[],"approved_symbol":"HUS1B","ensembl_gene_id":"ENSG00000188996","hgnc_id":"HGNC:16485","ncbi_gene_id":135458,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HUS1B","release_manifest":"api/v1.1/release_manifest.json"}},"HUWE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HUWE1","identifiers":{"aliases":["Ib772","KIAA0312","UREB1"],"approved_symbol":"HUWE1","ensembl_gene_id":"ENSG00000086758","hgnc_id":"HGNC:30892","ncbi_gene_id":10075,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HUWE1","release_manifest":"api/v1.1/release_manifest.json"}},"HVCN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HVCN1","identifiers":{"aliases":["MGC15619","Hv1","VSOP"],"approved_symbol":"HVCN1","ensembl_gene_id":"ENSG00000122986","hgnc_id":"HGNC:28240","ncbi_gene_id":84329,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HVCN1","release_manifest":"api/v1.1/release_manifest.json"}},"HYAL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYAL1","identifiers":{"aliases":["LUCA1","HYAL-1"],"approved_symbol":"HYAL1","ensembl_gene_id":"ENSG00000114378","hgnc_id":"HGNC:5320","ncbi_gene_id":3373,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYAL1","release_manifest":"api/v1.1/release_manifest.json"}},"HYAL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYAL2","identifiers":{"aliases":["LuCa-2","LUCA2"],"approved_symbol":"HYAL2","ensembl_gene_id":"ENSG00000068001","hgnc_id":"HGNC:5321","ncbi_gene_id":8692,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYAL2","release_manifest":"api/v1.1/release_manifest.json"}},"HYAL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYAL3","identifiers":{"aliases":["LUCA-3","LUCA14","Minna14"],"approved_symbol":"HYAL3","ensembl_gene_id":"ENSG00000186792","hgnc_id":"HGNC:5322","ncbi_gene_id":8372,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYAL3","release_manifest":"api/v1.1/release_manifest.json"}},"HYDIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYDIN","identifiers":{"aliases":["DKFZp434D0513","KIAA1864","PPP1R31","CILD5"],"approved_symbol":"HYDIN","ensembl_gene_id":"ENSG00000157423","hgnc_id":"HGNC:19368","ncbi_gene_id":54768,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYDIN","release_manifest":"api/v1.1/release_manifest.json"}},"HYI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYI","identifiers":{"aliases":["HT036"],"approved_symbol":"HYI","ensembl_gene_id":"ENSG00000178922","hgnc_id":"HGNC:26948","ncbi_gene_id":81888,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYI","release_manifest":"api/v1.1/release_manifest.json"}},"HYI-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYI-AS1","identifiers":{"aliases":[],"approved_symbol":"HYI-AS1","ensembl_gene_id":"ENSG00000229348","hgnc_id":"HGNC:41173","ncbi_gene_id":100873923,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/HYI-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"HYKK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYKK","identifiers":{"aliases":["LOC123688"],"approved_symbol":"HYKK","ensembl_gene_id":"ENSG00000188266","hgnc_id":"HGNC:34403","ncbi_gene_id":123688,"previous_symbols":["AGPHD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYKK","release_manifest":"api/v1.1/release_manifest.json"}},"HYLS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYLS1","identifiers":{"aliases":["FLJ32915"],"approved_symbol":"HYLS1","ensembl_gene_id":"ENSG00000198331","hgnc_id":"HGNC:26558","ncbi_gene_id":219844,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYLS1","release_manifest":"api/v1.1/release_manifest.json"}},"HYMAI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYMAI","identifiers":{"aliases":["NCRNA00020"],"approved_symbol":"HYMAI","ensembl_gene_id":"ENSG00000283122","hgnc_id":"HGNC:5326","ncbi_gene_id":57061,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYMAI","release_manifest":"api/v1.1/release_manifest.json"}},"HYOU1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYOU1","identifiers":{"aliases":["ORP150","HSP12A","Grp170"],"approved_symbol":"HYOU1","ensembl_gene_id":"ENSG00000149428","hgnc_id":"HGNC:16931","ncbi_gene_id":10525,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYOU1","release_manifest":"api/v1.1/release_manifest.json"}},"HYPK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"HYPK","identifiers":{"aliases":["HSPC136","FLJ20431"],"approved_symbol":"HYPK","ensembl_gene_id":"ENSG00000242028","hgnc_id":"HGNC:18418","ncbi_gene_id":25764,"previous_symbols":["C15orf63"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/HYPK","release_manifest":"api/v1.1/release_manifest.json"}}}
