{"D2HGDH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"D2HGDH","identifiers":{"aliases":["MGC25181","D2HGD","FLJ42195"],"approved_symbol":"D2HGDH","ensembl_gene_id":"ENSG00000180902","hgnc_id":"HGNC:28358","ncbi_gene_id":728294,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/D2HGDH","release_manifest":"api/v1.1/release_manifest.json"}},"DAAM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAAM1","identifiers":{"aliases":["KIAA0666"],"approved_symbol":"DAAM1","ensembl_gene_id":"ENSG00000100592","hgnc_id":"HGNC:18142","ncbi_gene_id":23002,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAAM1","release_manifest":"api/v1.1/release_manifest.json"}},"DAAM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAAM2","identifiers":{"aliases":["KIAA0381","NPHS24"],"approved_symbol":"DAAM2","ensembl_gene_id":"ENSG00000146122","hgnc_id":"HGNC:18143","ncbi_gene_id":23500,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAAM2","release_manifest":"api/v1.1/release_manifest.json"}},"DAB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAB1","identifiers":{"aliases":[],"approved_symbol":"DAB1","ensembl_gene_id":"ENSG00000173406","hgnc_id":"HGNC:2661","ncbi_gene_id":1600,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAB1","release_manifest":"api/v1.1/release_manifest.json"}},"DAB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAB2","identifiers":{"aliases":["DOC-2"],"approved_symbol":"DAB2","ensembl_gene_id":"ENSG00000153071","hgnc_id":"HGNC:2662","ncbi_gene_id":1601,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAB2","release_manifest":"api/v1.1/release_manifest.json"}},"DAB2IP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAB2IP","identifiers":{"aliases":["AF9Q34","DIP1/2","KIAA1743","AIP1"],"approved_symbol":"DAB2IP","ensembl_gene_id":"ENSG00000136848","hgnc_id":"HGNC:17294","ncbi_gene_id":153090,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAB2IP","release_manifest":"api/v1.1/release_manifest.json"}},"DACH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DACH1","identifiers":{"aliases":[],"approved_symbol":"DACH1","ensembl_gene_id":"ENSG00000276644","hgnc_id":"HGNC:2663","ncbi_gene_id":1602,"previous_symbols":["DACH"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DACH1","release_manifest":"api/v1.1/release_manifest.json"}},"DACH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DACH2","identifiers":{"aliases":[],"approved_symbol":"DACH2","ensembl_gene_id":"ENSG00000126733","hgnc_id":"HGNC:16814","ncbi_gene_id":117154,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DACH2","release_manifest":"api/v1.1/release_manifest.json"}},"DACT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DACT1","identifiers":{"aliases":["DAPPER1","THYEX3","HDPR1","DAPPER","FRODO"],"approved_symbol":"DACT1","ensembl_gene_id":"ENSG00000165617","hgnc_id":"HGNC:17748","ncbi_gene_id":51339,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DACT1","release_manifest":"api/v1.1/release_manifest.json"}},"DACT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DACT2","identifiers":{"aliases":["bA503C24.7","DAPPER2"],"approved_symbol":"DACT2","ensembl_gene_id":"ENSG00000164488","hgnc_id":"HGNC:21231","ncbi_gene_id":168002,"previous_symbols":["C6orf116"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DACT2","release_manifest":"api/v1.1/release_manifest.json"}},"DACT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DACT3","identifiers":{"aliases":["MGC15476","DAPPER3"],"approved_symbol":"DACT3","ensembl_gene_id":"ENSG00000197380","hgnc_id":"HGNC:30745","ncbi_gene_id":147906,"previous_symbols":["RRR1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DACT3","release_manifest":"api/v1.1/release_manifest.json"}},"DACT3-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DACT3-AS1","identifiers":{"aliases":[],"approved_symbol":"DACT3-AS1","ensembl_gene_id":"ENSG00000245598","hgnc_id":"HGNC:44120","ncbi_gene_id":100506068,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DACT3-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DAD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAD1","identifiers":{"aliases":["OST2"],"approved_symbol":"DAD1","ensembl_gene_id":"ENSG00000129562","hgnc_id":"HGNC:2664","ncbi_gene_id":1603,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAD1","release_manifest":"api/v1.1/release_manifest.json"}},"DAG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAG1","identifiers":{"aliases":["A3a","156DAG","AGRNR","DAG"],"approved_symbol":"DAG1","ensembl_gene_id":"ENSG00000173402","hgnc_id":"HGNC:2666","ncbi_gene_id":1605,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAG1","release_manifest":"api/v1.1/release_manifest.json"}},"DAGLA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAGLA","identifiers":{"aliases":["KIAA0659","NSDDR","DAGLALPHA"],"approved_symbol":"DAGLA","ensembl_gene_id":"ENSG00000134780","hgnc_id":"HGNC:1165","ncbi_gene_id":747,"previous_symbols":["C11orf11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAGLA","release_manifest":"api/v1.1/release_manifest.json"}},"DAGLB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAGLB","identifiers":{"aliases":["KCCR13L","DAGLBETA"],"approved_symbol":"DAGLB","ensembl_gene_id":"ENSG00000164535","hgnc_id":"HGNC:28923","ncbi_gene_id":221955,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAGLB","release_manifest":"api/v1.1/release_manifest.json"}},"DALRD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DALRD3","identifiers":{"aliases":["FLJ10496"],"approved_symbol":"DALRD3","ensembl_gene_id":"ENSG00000178149","hgnc_id":"HGNC:25536","ncbi_gene_id":55152,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DALRD3","release_manifest":"api/v1.1/release_manifest.json"}},"DANCR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DANCR","identifiers":{"aliases":["ANCR","AGU2","lncRNA-ANCR"],"approved_symbol":"DANCR","ensembl_gene_id":"ENSG00000226950","hgnc_id":"HGNC:28964","ncbi_gene_id":57291,"previous_symbols":["KIAA0114","SNHG13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DANCR","release_manifest":"api/v1.1/release_manifest.json"}},"DAND5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAND5","identifiers":{"aliases":["FLJ38607","CKTSF1B3","DANTE","GREM3","CER2","DTE","Coco"],"approved_symbol":"DAND5","ensembl_gene_id":"ENSG00000179284","hgnc_id":"HGNC:26780","ncbi_gene_id":199699,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DAND5","release_manifest":"api/v1.1/release_manifest.json"}},"DANT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DANT1","identifiers":{"aliases":[],"approved_symbol":"DANT1","ensembl_gene_id":"ENSG00000229335","hgnc_id":"HGNC:50863","ncbi_gene_id":106029310,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DANT1","release_manifest":"api/v1.1/release_manifest.json"}},"DANT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DANT2","identifiers":{"aliases":[],"approved_symbol":"DANT2","ensembl_gene_id":"ENSG00000235244","hgnc_id":"HGNC:50862","ncbi_gene_id":642776,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DANT2","release_manifest":"api/v1.1/release_manifest.json"}},"DAP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAP","identifiers":{"aliases":["DAP1"],"approved_symbol":"DAP","ensembl_gene_id":"ENSG00000112977","hgnc_id":"HGNC:2672","ncbi_gene_id":1611,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAP","release_manifest":"api/v1.1/release_manifest.json"}},"DAP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAP3","identifiers":{"aliases":["MRPS29","DAP-3","MRP-S29","bMRP-10","MGC126058","MGC126059","DKFZp686G12159","mS29"],"approved_symbol":"DAP3","ensembl_gene_id":"ENSG00000132676","hgnc_id":"HGNC:2673","ncbi_gene_id":7818,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAP3","release_manifest":"api/v1.1/release_manifest.json"}},"DAPK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAPK1","identifiers":{"aliases":["DAPK"],"approved_symbol":"DAPK1","ensembl_gene_id":"ENSG00000196730","hgnc_id":"HGNC:2674","ncbi_gene_id":1612,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAPK1","release_manifest":"api/v1.1/release_manifest.json"}},"DAPK1-IT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAPK1-IT1","identifiers":{"aliases":[],"approved_symbol":"DAPK1-IT1","ensembl_gene_id":"ENSG00000236709","hgnc_id":"HGNC:43591","ncbi_gene_id":100506897,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAPK1-IT1","release_manifest":"api/v1.1/release_manifest.json"}},"DAPK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAPK2","identifiers":{"aliases":["DRP-1","MGC119312"],"approved_symbol":"DAPK2","ensembl_gene_id":"ENSG00000035664","hgnc_id":"HGNC:2675","ncbi_gene_id":23604,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAPK2","release_manifest":"api/v1.1/release_manifest.json"}},"DAPK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAPK3","identifiers":{"aliases":["ZIP","ZIPK"],"approved_symbol":"DAPK3","ensembl_gene_id":"ENSG00000167657","hgnc_id":"HGNC:2676","ncbi_gene_id":1613,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAPK3","release_manifest":"api/v1.1/release_manifest.json"}},"DAPL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAPL1","identifiers":{"aliases":[],"approved_symbol":"DAPL1","ensembl_gene_id":"ENSG00000163331","hgnc_id":"HGNC:21490","ncbi_gene_id":92196,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DAPL1","release_manifest":"api/v1.1/release_manifest.json"}},"DAPP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAPP1","identifiers":{"aliases":["BAM32"],"approved_symbol":"DAPP1","ensembl_gene_id":"ENSG00000070190","hgnc_id":"HGNC:16500","ncbi_gene_id":27071,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAPP1","release_manifest":"api/v1.1/release_manifest.json"}},"DARS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DARS","identifiers":{"approved_symbol":"DARS","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DARS","release_manifest":"api/v1.1/release_manifest.json"}},"DARS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DARS2","identifiers":{"aliases":["FLJ10514","mtAspRS"],"approved_symbol":"DARS2","ensembl_gene_id":"ENSG00000117593","hgnc_id":"HGNC:25538","ncbi_gene_id":55157,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DARS2","release_manifest":"api/v1.1/release_manifest.json"}},"DAW1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAW1","identifiers":{"aliases":["FLJ25955","ODA16","DNAAF18"],"approved_symbol":"DAW1","ensembl_gene_id":"ENSG00000123977","hgnc_id":"HGNC:26383","ncbi_gene_id":164781,"previous_symbols":["WDR69"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAW1","release_manifest":"api/v1.1/release_manifest.json"}},"DAXX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAXX","identifiers":{"aliases":["DAP6"],"approved_symbol":"DAXX","ensembl_gene_id":"ENSG00000204209","hgnc_id":"HGNC:2681","ncbi_gene_id":1616,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAXX","release_manifest":"api/v1.1/release_manifest.json"}},"DAZAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAZAP1","identifiers":{"aliases":["MGC19907"],"approved_symbol":"DAZAP1","ensembl_gene_id":"ENSG00000071626","hgnc_id":"HGNC:2683","ncbi_gene_id":26528,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAZAP1","release_manifest":"api/v1.1/release_manifest.json"}},"DAZAP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DAZAP2","identifiers":{"aliases":["KIAA0058"],"approved_symbol":"DAZAP2","ensembl_gene_id":"ENSG00000183283","hgnc_id":"HGNC:2684","ncbi_gene_id":9802,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DAZAP2","release_manifest":"api/v1.1/release_manifest.json"}},"DBF4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBF4","identifiers":{"aliases":["ASK","chif","ZDBF1","DBF4A"],"approved_symbol":"DBF4","ensembl_gene_id":"ENSG00000006634","hgnc_id":"HGNC:17364","ncbi_gene_id":10926,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBF4","release_manifest":"api/v1.1/release_manifest.json"}},"DBF4B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBF4B","identifiers":{"aliases":["FLJ13087","DRF1","ASKL1","chifb","ZDBF1B"],"approved_symbol":"DBF4B","ensembl_gene_id":"ENSG00000161692","hgnc_id":"HGNC:17883","ncbi_gene_id":80174,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBF4B","release_manifest":"api/v1.1/release_manifest.json"}},"DBH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBH","identifiers":{"aliases":["DBM"],"approved_symbol":"DBH","ensembl_gene_id":"ENSG00000123454","hgnc_id":"HGNC:2689","ncbi_gene_id":1621,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DBH","release_manifest":"api/v1.1/release_manifest.json"}},"DBH-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBH-AS1","identifiers":{"aliases":["BPR"],"approved_symbol":"DBH-AS1","ensembl_gene_id":"ENSG00000225756","hgnc_id":"HGNC:24155","ncbi_gene_id":138948,"previous_symbols":["NCRNA00118"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DBH-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DBI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBI","identifiers":{"aliases":["ACBP","ACBD1"],"approved_symbol":"DBI","ensembl_gene_id":"ENSG00000155368","hgnc_id":"HGNC:2690","ncbi_gene_id":1622,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBI","release_manifest":"api/v1.1/release_manifest.json"}},"DBN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBN1","identifiers":{"aliases":[],"approved_symbol":"DBN1","ensembl_gene_id":"ENSG00000113758","hgnc_id":"HGNC:2695","ncbi_gene_id":1627,"previous_symbols":["D0S117E"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBN1","release_manifest":"api/v1.1/release_manifest.json"}},"DBNDD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBNDD1","identifiers":{"aliases":["MGC3101","FLJ12582"],"approved_symbol":"DBNDD1","ensembl_gene_id":"ENSG00000003249","hgnc_id":"HGNC:28455","ncbi_gene_id":79007,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DBNDD1","release_manifest":"api/v1.1/release_manifest.json"}},"DBNDD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBNDD2","identifiers":{"aliases":["HSMNP1"],"approved_symbol":"DBNDD2","ensembl_gene_id":"ENSG00000244274","hgnc_id":"HGNC:15881","ncbi_gene_id":55861,"previous_symbols":["C20orf35"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBNDD2","release_manifest":"api/v1.1/release_manifest.json"}},"DBNL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBNL","identifiers":{"aliases":["SH3P7","HIP-55","ABP1"],"approved_symbol":"DBNL","ensembl_gene_id":"ENSG00000136279","hgnc_id":"HGNC:2696","ncbi_gene_id":28988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DBNL","release_manifest":"api/v1.1/release_manifest.json"}},"DBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBP","identifiers":{"aliases":["DABP"],"approved_symbol":"DBP","ensembl_gene_id":"ENSG00000105516","hgnc_id":"HGNC:2697","ncbi_gene_id":1628,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBP","release_manifest":"api/v1.1/release_manifest.json"}},"DBR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBR1","identifiers":{"aliases":[],"approved_symbol":"DBR1","ensembl_gene_id":"ENSG00000138231","hgnc_id":"HGNC:15594","ncbi_gene_id":51163,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBR1","release_manifest":"api/v1.1/release_manifest.json"}},"DBT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBT","identifiers":{"aliases":["BCOADC-E2","BCKAD-E2","BCKDH-E2"],"approved_symbol":"DBT","ensembl_gene_id":"ENSG00000137992","hgnc_id":"HGNC:2698","ncbi_gene_id":1629,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DBT","release_manifest":"api/v1.1/release_manifest.json"}},"DBX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBX1","identifiers":{"aliases":[],"approved_symbol":"DBX1","ensembl_gene_id":"ENSG00000109851","hgnc_id":"HGNC:33185","ncbi_gene_id":120237,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DBX1","release_manifest":"api/v1.1/release_manifest.json"}},"DBX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DBX2","identifiers":{"aliases":["FLJ16139"],"approved_symbol":"DBX2","ensembl_gene_id":"ENSG00000185610","hgnc_id":"HGNC:33186","ncbi_gene_id":440097,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DBX2","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF1","identifiers":{"aliases":["KIAA0800","MGC102804"],"approved_symbol":"DCAF1","ensembl_gene_id":"ENSG00000145041","hgnc_id":"HGNC:30911","ncbi_gene_id":9730,"previous_symbols":["VPRBP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF1","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF10","identifiers":{"aliases":["MGC10765","FLJ23201"],"approved_symbol":"DCAF10","ensembl_gene_id":"ENSG00000122741","hgnc_id":"HGNC:23686","ncbi_gene_id":79269,"previous_symbols":["WDR32"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF10","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF11","identifiers":{"aliases":["PRO2389","GL014"],"approved_symbol":"DCAF11","ensembl_gene_id":"ENSG00000100897","hgnc_id":"HGNC:20258","ncbi_gene_id":80344,"previous_symbols":["WDR23"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF11","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF12","identifiers":{"aliases":["DKFZP434O125","MGC1058","CT102","TCC52"],"approved_symbol":"DCAF12","ensembl_gene_id":"ENSG00000198876","hgnc_id":"HGNC:19911","ncbi_gene_id":25853,"previous_symbols":["KIAA1892","WDR40A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF12","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF12L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF12L1","identifiers":{"aliases":["KIAA1892L"],"approved_symbol":"DCAF12L1","ensembl_gene_id":"ENSG00000198889","hgnc_id":"HGNC:29395","ncbi_gene_id":139170,"previous_symbols":["WDR40B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DCAF12L1","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF12L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF12L2","identifiers":{"aliases":[],"approved_symbol":"DCAF12L2","ensembl_gene_id":"ENSG00000198354","hgnc_id":"HGNC:32950","ncbi_gene_id":340578,"previous_symbols":["WDR40C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF12L2","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF13","identifiers":{"aliases":["DKFZP564O0463","Gm83","HSPC064","Sof1"],"approved_symbol":"DCAF13","ensembl_gene_id":"ENSG00000164934","hgnc_id":"HGNC:24535","ncbi_gene_id":25879,"previous_symbols":["WDSOF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DCAF13","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF15","identifiers":{"aliases":["MGC99481"],"approved_symbol":"DCAF15","ensembl_gene_id":"ENSG00000132017","hgnc_id":"HGNC:25095","ncbi_gene_id":90379,"previous_symbols":["C19orf72"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF15","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF16","identifiers":{"aliases":["FLJ20280"],"approved_symbol":"DCAF16","ensembl_gene_id":"ENSG00000163257","hgnc_id":"HGNC:25987","ncbi_gene_id":54876,"previous_symbols":["C4orf30"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF16","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF17","identifiers":{"aliases":["FLJ13096"],"approved_symbol":"DCAF17","ensembl_gene_id":"ENSG00000115827","hgnc_id":"HGNC:25784","ncbi_gene_id":80067,"previous_symbols":["C2orf37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF17","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF4","identifiers":{"aliases":["DKFZp434K114"],"approved_symbol":"DCAF4","ensembl_gene_id":"ENSG00000119599","hgnc_id":"HGNC:20229","ncbi_gene_id":26094,"previous_symbols":["WDR21","WDR21A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF4","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF4L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF4L1","identifiers":{"aliases":[],"approved_symbol":"DCAF4L1","ensembl_gene_id":"ENSG00000182308","hgnc_id":"HGNC:27723","ncbi_gene_id":285429,"previous_symbols":["WDR21B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DCAF4L1","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF5","identifiers":{"aliases":["BCRP2","D14S1461E","BCRG2","KIAA1824"],"approved_symbol":"DCAF5","ensembl_gene_id":"ENSG00000139990","hgnc_id":"HGNC:20224","ncbi_gene_id":8816,"previous_symbols":["WDR22"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF5","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF6","identifiers":{"aliases":["PC326"],"approved_symbol":"DCAF6","ensembl_gene_id":"ENSG00000143164","hgnc_id":"HGNC:30002","ncbi_gene_id":55827,"previous_symbols":["IQWD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF6","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF7","identifiers":{"aliases":["HAN11","SWAN-1"],"approved_symbol":"DCAF7","ensembl_gene_id":"ENSG00000136485","hgnc_id":"HGNC:30915","ncbi_gene_id":10238,"previous_symbols":["WDR68"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAF7","release_manifest":"api/v1.1/release_manifest.json"}},"DCAF8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAF8","identifiers":{"aliases":["H326","FLJ35857"],"approved_symbol":"DCAF8","ensembl_gene_id":"ENSG00000132716","hgnc_id":"HGNC:24891","ncbi_gene_id":50717,"previous_symbols":["WDR42A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DCAF8","release_manifest":"api/v1.1/release_manifest.json"}},"DCAKD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCAKD","identifiers":{"aliases":["FLJ22955"],"approved_symbol":"DCAKD","ensembl_gene_id":"ENSG00000172992","hgnc_id":"HGNC:26238","ncbi_gene_id":79877,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCAKD","release_manifest":"api/v1.1/release_manifest.json"}},"DCBLD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCBLD1","identifiers":{"aliases":["MGC46341","dJ94G16.1"],"approved_symbol":"DCBLD1","ensembl_gene_id":"ENSG00000164465","hgnc_id":"HGNC:21479","ncbi_gene_id":285761,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCBLD1","release_manifest":"api/v1.1/release_manifest.json"}},"DCBLD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCBLD2","identifiers":{"aliases":["CLCP1","ESDN"],"approved_symbol":"DCBLD2","ensembl_gene_id":"ENSG00000057019","hgnc_id":"HGNC:24627","ncbi_gene_id":131566,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCBLD2","release_manifest":"api/v1.1/release_manifest.json"}},"DCC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCC","identifiers":{"aliases":["IGDCC1","NTN1R1"],"approved_symbol":"DCC","ensembl_gene_id":"ENSG00000187323","hgnc_id":"HGNC:2701","ncbi_gene_id":1630,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCC","release_manifest":"api/v1.1/release_manifest.json"}},"DCDC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCDC1","identifiers":{"aliases":["FLJ46154"],"approved_symbol":"DCDC1","ensembl_gene_id":"ENSG00000170959","hgnc_id":"HGNC:20625","ncbi_gene_id":341019,"previous_symbols":["DCDC5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCDC1","release_manifest":"api/v1.1/release_manifest.json"}},"DCDC2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCDC2B","identifiers":{"aliases":[],"approved_symbol":"DCDC2B","ensembl_gene_id":"ENSG00000222046","hgnc_id":"HGNC:32576","ncbi_gene_id":149069,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCDC2B","release_manifest":"api/v1.1/release_manifest.json"}},"DCDC2C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCDC2C","identifiers":{"aliases":[],"approved_symbol":"DCDC2C","ensembl_gene_id":"ENSG00000214866","hgnc_id":"HGNC:32696","ncbi_gene_id":728597,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCDC2C","release_manifest":"api/v1.1/release_manifest.json"}},"DCHS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCHS1","identifiers":{"aliases":["FIB1","KIAA1773","FLJ11790","CDHR6"],"approved_symbol":"DCHS1","ensembl_gene_id":"ENSG00000166341","hgnc_id":"HGNC:13681","ncbi_gene_id":8642,"previous_symbols":["CDH25","PCDH16"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCHS1","release_manifest":"api/v1.1/release_manifest.json"}},"DCHS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCHS2","identifiers":{"aliases":["CDHJ","FLJ20047","PCDHJ","CDHR7"],"approved_symbol":"DCHS2","ensembl_gene_id":"ENSG00000197410","hgnc_id":"HGNC:23111","ncbi_gene_id":54798,"previous_symbols":["CDH27","PCDH23"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DCHS2","release_manifest":"api/v1.1/release_manifest.json"}},"DCK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCK","identifiers":{"aliases":[],"approved_symbol":"DCK","ensembl_gene_id":"ENSG00000156136","hgnc_id":"HGNC:2704","ncbi_gene_id":1633,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCK","release_manifest":"api/v1.1/release_manifest.json"}},"DCLK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCLK1","identifiers":{"aliases":["KIAA0369","DCLK","DCDC3A"],"approved_symbol":"DCLK1","ensembl_gene_id":"ENSG00000133083","hgnc_id":"HGNC:2700","ncbi_gene_id":9201,"previous_symbols":["DCAMKL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCLK1","release_manifest":"api/v1.1/release_manifest.json"}},"DCLK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCLK2","identifiers":{"aliases":["MGC45428","DCDC3","DCDC3B","DCK2"],"approved_symbol":"DCLK2","ensembl_gene_id":"ENSG00000170390","hgnc_id":"HGNC:19002","ncbi_gene_id":166614,"previous_symbols":["DCAMKL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCLK2","release_manifest":"api/v1.1/release_manifest.json"}},"DCLK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCLK3","identifiers":{"aliases":["KIAA1765","DCDC3C"],"approved_symbol":"DCLK3","ensembl_gene_id":"ENSG00000163673","hgnc_id":"HGNC:19005","ncbi_gene_id":85443,"previous_symbols":["DCAMKL3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCLK3","release_manifest":"api/v1.1/release_manifest.json"}},"DCLRE1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCLRE1A","identifiers":{"aliases":["SNM1","PSO2","KIAA0086","hSNM1"],"approved_symbol":"DCLRE1A","ensembl_gene_id":"ENSG00000198924","hgnc_id":"HGNC:17660","ncbi_gene_id":9937,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCLRE1A","release_manifest":"api/v1.1/release_manifest.json"}},"DCLRE1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCLRE1B","identifiers":{"aliases":["SNM1B","FLJ12810","FLJ13998","APOLLO"],"approved_symbol":"DCLRE1B","ensembl_gene_id":"ENSG00000118655","hgnc_id":"HGNC:17641","ncbi_gene_id":64858,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCLRE1B","release_manifest":"api/v1.1/release_manifest.json"}},"DCLRE1C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCLRE1C","identifiers":{"aliases":["ARTEMIS","FLJ11360","SNM1C","A-SCID"],"approved_symbol":"DCLRE1C","ensembl_gene_id":"ENSG00000152457","hgnc_id":"HGNC:17642","ncbi_gene_id":64421,"previous_symbols":["SCIDA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCLRE1C","release_manifest":"api/v1.1/release_manifest.json"}},"DCN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCN","identifiers":{"aliases":["DSPG2","SLRR1B"],"approved_symbol":"DCN","ensembl_gene_id":"ENSG00000011465","hgnc_id":"HGNC:2705","ncbi_gene_id":1634,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DCN","detailed_audit_record":"gene/DCN/audit","legacy_api_record":"api/v1/genes/DCN.json","release_manifest":"api/v1.1/release_manifest.json"}},"DCP1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCP1A","identifiers":{"aliases":["HSA275986","SMIF","SMAD4IP1"],"approved_symbol":"DCP1A","ensembl_gene_id":"ENSG00000272886","hgnc_id":"HGNC:18714","ncbi_gene_id":55802,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCP1A","release_manifest":"api/v1.1/release_manifest.json"}},"DCP1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCP1B","identifiers":{"aliases":["FLJ31638"],"approved_symbol":"DCP1B","ensembl_gene_id":"ENSG00000151065","hgnc_id":"HGNC:24451","ncbi_gene_id":196513,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCP1B","release_manifest":"api/v1.1/release_manifest.json"}},"DCP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCP2","identifiers":{"aliases":["NUDT20"],"approved_symbol":"DCP2","ensembl_gene_id":"ENSG00000172795","hgnc_id":"HGNC:24452","ncbi_gene_id":167227,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCP2","release_manifest":"api/v1.1/release_manifest.json"}},"DCPS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCPS","identifiers":{"aliases":["HSPC015","HINT-5","HSL1","HINT5","DCS-1","DCS1"],"approved_symbol":"DCPS","ensembl_gene_id":"ENSG00000110063","hgnc_id":"HGNC:29812","ncbi_gene_id":28960,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCPS","release_manifest":"api/v1.1/release_manifest.json"}},"DCST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCST1","identifiers":{"aliases":["FLJ32785"],"approved_symbol":"DCST1","ensembl_gene_id":"ENSG00000163357","hgnc_id":"HGNC:26539","ncbi_gene_id":149095,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DCST1","release_manifest":"api/v1.1/release_manifest.json"}},"DCST1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCST1-AS1","identifiers":{"aliases":["RP11-307C12.11"],"approved_symbol":"DCST1-AS1","ensembl_gene_id":"ENSG00000232093","hgnc_id":"HGNC:41147","ncbi_gene_id":100505666,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DCST1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DCST2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCST2","identifiers":{"aliases":["FLJ32934"],"approved_symbol":"DCST2","ensembl_gene_id":"ENSG00000163354","hgnc_id":"HGNC:26562","ncbi_gene_id":127579,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCST2","release_manifest":"api/v1.1/release_manifest.json"}},"DCSTAMP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCSTAMP","identifiers":{"aliases":["DC-STAMP","FIND"],"approved_symbol":"DCSTAMP","ensembl_gene_id":"ENSG00000164935","hgnc_id":"HGNC:18549","ncbi_gene_id":81501,"previous_symbols":["TM7SF4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCSTAMP","release_manifest":"api/v1.1/release_manifest.json"}},"DCT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCT","identifiers":{"aliases":["TRP-2","TRP2"],"approved_symbol":"DCT","ensembl_gene_id":"ENSG00000080166","hgnc_id":"HGNC:2709","ncbi_gene_id":1638,"previous_symbols":["TYRP2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCT","release_manifest":"api/v1.1/release_manifest.json"}},"DCTD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTD","identifiers":{"aliases":[],"approved_symbol":"DCTD","ensembl_gene_id":"ENSG00000129187","hgnc_id":"HGNC:2710","ncbi_gene_id":1635,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTD","release_manifest":"api/v1.1/release_manifest.json"}},"DCTN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTN1","identifiers":{"aliases":[],"approved_symbol":"DCTN1","ensembl_gene_id":"ENSG00000204843","hgnc_id":"HGNC:2711","ncbi_gene_id":1639,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":true,"effect_size":0.71721,"fdr":0.092251,"context":"GSE293514_myoblast_fusion_screen","interpretation":"screen_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTN1","release_manifest":"api/v1.1/release_manifest.json"}},"DCTN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTN2","identifiers":{"aliases":["RBP50","DCTN-50"],"approved_symbol":"DCTN2","ensembl_gene_id":"ENSG00000175203","hgnc_id":"HGNC:2712","ncbi_gene_id":10540,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTN2","release_manifest":"api/v1.1/release_manifest.json"}},"DCTN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTN3","identifiers":{"aliases":["DCTN-22"],"approved_symbol":"DCTN3","ensembl_gene_id":"ENSG00000137100","hgnc_id":"HGNC:2713","ncbi_gene_id":11258,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTN3","release_manifest":"api/v1.1/release_manifest.json"}},"DCTN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTN4","identifiers":{"aliases":["Dyn4","p62"],"approved_symbol":"DCTN4","ensembl_gene_id":"ENSG00000132912","hgnc_id":"HGNC:15518","ncbi_gene_id":51164,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTN4","release_manifest":"api/v1.1/release_manifest.json"}},"DCTN5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTN5","identifiers":{"aliases":["MGC3248","p25"],"approved_symbol":"DCTN5","ensembl_gene_id":"ENSG00000166847","hgnc_id":"HGNC:24594","ncbi_gene_id":84516,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTN5","release_manifest":"api/v1.1/release_manifest.json"}},"DCTN6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTN6","identifiers":{"aliases":["WS-3","p27"],"approved_symbol":"DCTN6","ensembl_gene_id":"ENSG00000104671","hgnc_id":"HGNC:16964","ncbi_gene_id":10671,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTN6","release_manifest":"api/v1.1/release_manifest.json"}},"DCTPP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCTPP1","identifiers":{"aliases":["MGC5627","RS21C6","CDA03","XTP3TPA"],"approved_symbol":"DCTPP1","ensembl_gene_id":"ENSG00000179958","hgnc_id":"HGNC:28777","ncbi_gene_id":79077,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCTPP1","release_manifest":"api/v1.1/release_manifest.json"}},"DCUN1D1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCUN1D1","identifiers":{"aliases":["RP42","SCRO","DCUN1L1","Tes3","SCCRO"],"approved_symbol":"DCUN1D1","ensembl_gene_id":"ENSG00000043093","hgnc_id":"HGNC:18184","ncbi_gene_id":54165,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCUN1D1","release_manifest":"api/v1.1/release_manifest.json"}},"DCUN1D2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCUN1D2","identifiers":{"aliases":["FLJ10704","FLJ20092"],"approved_symbol":"DCUN1D2","ensembl_gene_id":"ENSG00000150401","hgnc_id":"HGNC:20328","ncbi_gene_id":55208,"previous_symbols":["C13orf17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCUN1D2","release_manifest":"api/v1.1/release_manifest.json"}},"DCUN1D3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCUN1D3","identifiers":{"aliases":["MGC48972","FLJ41725","DKFZp686O0290","SCCRO3"],"approved_symbol":"DCUN1D3","ensembl_gene_id":"ENSG00000188215","hgnc_id":"HGNC:28734","ncbi_gene_id":123879,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCUN1D3","release_manifest":"api/v1.1/release_manifest.json"}},"DCUN1D4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCUN1D4","identifiers":{"aliases":["KIAA0276"],"approved_symbol":"DCUN1D4","ensembl_gene_id":"ENSG00000109184","hgnc_id":"HGNC:28998","ncbi_gene_id":23142,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCUN1D4","release_manifest":"api/v1.1/release_manifest.json"}},"DCUN1D5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCUN1D5","identifiers":{"aliases":["MGC2714","FLJ32431"],"approved_symbol":"DCUN1D5","ensembl_gene_id":"ENSG00000137692","hgnc_id":"HGNC:28409","ncbi_gene_id":84259,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.13408,"fdr":0.97276,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCUN1D5","release_manifest":"api/v1.1/release_manifest.json"}},"DCX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCX","identifiers":{"aliases":["SCLH","DC","LISX","DBCN","XLIS"],"approved_symbol":"DCX","ensembl_gene_id":"ENSG00000077279","hgnc_id":"HGNC:2714","ncbi_gene_id":1641,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCX","release_manifest":"api/v1.1/release_manifest.json"}},"DCXR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DCXR","identifiers":{"aliases":["KIDCR","DCR","SDR20C1","HCR2","P34H"],"approved_symbol":"DCXR","ensembl_gene_id":"ENSG00000169738","hgnc_id":"HGNC:18985","ncbi_gene_id":51181,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DCXR","release_manifest":"api/v1.1/release_manifest.json"}},"DDA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDA1","identifiers":{"aliases":["PCIA1","MGC2594"],"approved_symbol":"DDA1","ensembl_gene_id":"ENSG00000130311","hgnc_id":"HGNC:28360","ncbi_gene_id":79016,"previous_symbols":["C19orf58"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDA1","release_manifest":"api/v1.1/release_manifest.json"}},"DDAH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDAH1","identifiers":{"aliases":["DDAH"],"approved_symbol":"DDAH1","ensembl_gene_id":"ENSG00000153904","hgnc_id":"HGNC:2715","ncbi_gene_id":23576,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDAH1","release_manifest":"api/v1.1/release_manifest.json"}},"DDAH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDAH2","identifiers":{"aliases":["G6A","DDAHII"],"approved_symbol":"DDAH2","ensembl_gene_id":"ENSG00000213722","hgnc_id":"HGNC:2716","ncbi_gene_id":23564,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDAH2","release_manifest":"api/v1.1/release_manifest.json"}},"DDB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDB1","identifiers":{"aliases":[],"approved_symbol":"DDB1","ensembl_gene_id":"ENSG00000167986","hgnc_id":"HGNC:2717","ncbi_gene_id":1642,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDB1","release_manifest":"api/v1.1/release_manifest.json"}},"DDB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDB2","identifiers":{"aliases":["DDBB","UV-DDB2","FLJ34321","XPE"],"approved_symbol":"DDB2","ensembl_gene_id":"ENSG00000134574","hgnc_id":"HGNC:2718","ncbi_gene_id":1643,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDB2","release_manifest":"api/v1.1/release_manifest.json"}},"DDC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDC","identifiers":{"aliases":["AADC"],"approved_symbol":"DDC","ensembl_gene_id":"ENSG00000132437","hgnc_id":"HGNC:2719","ncbi_gene_id":1644,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DDC","release_manifest":"api/v1.1/release_manifest.json"}},"DDHD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDHD1","identifiers":{"aliases":["KIAA1705","PA-PLA1","iPLA1alpha","PAPLA1","iPLA1α"],"approved_symbol":"DDHD1","ensembl_gene_id":"ENSG00000100523","hgnc_id":"HGNC:19714","ncbi_gene_id":80821,"previous_symbols":["SPG28"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDHD1","release_manifest":"api/v1.1/release_manifest.json"}},"DDHD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDHD2","identifiers":{"aliases":["KIAA0725","SPG54","p125B","iPLA1gamma","iPLA1γ"],"approved_symbol":"DDHD2","ensembl_gene_id":"ENSG00000085788","hgnc_id":"HGNC:29106","ncbi_gene_id":23259,"previous_symbols":["SAMWD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDHD2","release_manifest":"api/v1.1/release_manifest.json"}},"DDI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDI2","identifiers":{"aliases":["MGC14844"],"approved_symbol":"DDI2","ensembl_gene_id":"ENSG00000197312","hgnc_id":"HGNC:24578","ncbi_gene_id":84301,"previous_symbols":["RSC1A1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DDI2","release_manifest":"api/v1.1/release_manifest.json"}},"DDIAS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDIAS","identifiers":{"aliases":["FLJ38838","FLJ25416","noxin"],"approved_symbol":"DDIAS","ensembl_gene_id":"ENSG00000165490","hgnc_id":"HGNC:26351","ncbi_gene_id":220042,"previous_symbols":["C11orf82"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDIAS","release_manifest":"api/v1.1/release_manifest.json"}},"DDIT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDIT3","identifiers":{"aliases":["CHOP10","GADD153","CHOP"],"approved_symbol":"DDIT3","ensembl_gene_id":"ENSG00000175197","hgnc_id":"HGNC:2726","ncbi_gene_id":1649,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDIT3","release_manifest":"api/v1.1/release_manifest.json"}},"DDIT4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDIT4","identifiers":{"aliases":["RTP801","FLJ20500","REDD-1","REDD1","Dig2"],"approved_symbol":"DDIT4","ensembl_gene_id":"ENSG00000168209","hgnc_id":"HGNC:24944","ncbi_gene_id":54541,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDIT4","release_manifest":"api/v1.1/release_manifest.json"}},"DDIT4L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDIT4L","identifiers":{"aliases":["REDD2","Rtp801L"],"approved_symbol":"DDIT4L","ensembl_gene_id":"ENSG00000145358","hgnc_id":"HGNC:30555","ncbi_gene_id":115265,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDIT4L","release_manifest":"api/v1.1/release_manifest.json"}},"DDN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDN","identifiers":{"aliases":["KIAA0749"],"approved_symbol":"DDN","ensembl_gene_id":"ENSG00000181418","hgnc_id":"HGNC:24458","ncbi_gene_id":23109,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DDN","release_manifest":"api/v1.1/release_manifest.json"}},"DDN-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDN-AS1","identifiers":{"aliases":["CAT1507"],"approved_symbol":"DDN-AS1","ensembl_gene_id":"ENSG00000257913","hgnc_id":"HGNC:53464","ncbi_gene_id":105369758,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDN-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DDO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDO","identifiers":{"aliases":["DASOX","DASPO"],"approved_symbol":"DDO","ensembl_gene_id":"ENSG00000203797","hgnc_id":"HGNC:2727","ncbi_gene_id":8528,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDO","release_manifest":"api/v1.1/release_manifest.json"}},"DDOST":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDOST","identifiers":{"aliases":["OST","KIAA0115","OST48","WBP1"],"approved_symbol":"DDOST","ensembl_gene_id":"ENSG00000244038","hgnc_id":"HGNC:2728","ncbi_gene_id":1650,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDOST","release_manifest":"api/v1.1/release_manifest.json"}},"DDR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDR1","identifiers":{"aliases":["RTK6","CD167"],"approved_symbol":"DDR1","ensembl_gene_id":"ENSG00000204580","hgnc_id":"HGNC:2730","ncbi_gene_id":780,"previous_symbols":["NTRK4","PTK3A","NEP","CAK","EDDR1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDR1","release_manifest":"api/v1.1/release_manifest.json"}},"DDR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDR2","identifiers":{"aliases":["TKT"],"approved_symbol":"DDR2","ensembl_gene_id":"ENSG00000162733","hgnc_id":"HGNC:2731","ncbi_gene_id":4921,"previous_symbols":["TYRO10","NTRKR3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDR2","release_manifest":"api/v1.1/release_manifest.json"}},"DDRGK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDRGK1","identifiers":{"aliases":["dJ1187M17.3","UFBP1"],"approved_symbol":"DDRGK1","ensembl_gene_id":"ENSG00000198171","hgnc_id":"HGNC:16110","ncbi_gene_id":65992,"previous_symbols":["C20orf116"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DDRGK1","release_manifest":"api/v1.1/release_manifest.json"}},"DDT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDT","identifiers":{"aliases":["DDCT","MIF2","MIF-2","D-DT"],"approved_symbol":"DDT","ensembl_gene_id":"ENSG00000099977","hgnc_id":"HGNC:2732","ncbi_gene_id":1652,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDT","release_manifest":"api/v1.1/release_manifest.json"}},"DDTL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDTL","identifiers":{"aliases":[],"approved_symbol":"DDTL","ensembl_gene_id":"ENSG00000099974","hgnc_id":"HGNC:33446","ncbi_gene_id":100037417,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDTL","release_manifest":"api/v1.1/release_manifest.json"}},"DDX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX1","identifiers":{"aliases":["TSLIG6","DBP-RB"],"approved_symbol":"DDX1","ensembl_gene_id":"ENSG00000079785","hgnc_id":"HGNC:2734","ncbi_gene_id":1653,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX1","release_manifest":"api/v1.1/release_manifest.json"}},"DDX10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX10","identifiers":{"aliases":["HRH-J8","Dbp4"],"approved_symbol":"DDX10","ensembl_gene_id":"ENSG00000178105","hgnc_id":"HGNC:2735","ncbi_gene_id":1662,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DDX10","release_manifest":"api/v1.1/release_manifest.json"}},"DDX11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX11","identifiers":{"aliases":["ChlR1","KRG-2","CHL1","WABS"],"approved_symbol":"DDX11","ensembl_gene_id":"ENSG00000013573","hgnc_id":"HGNC:2736","ncbi_gene_id":1663,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX11","release_manifest":"api/v1.1/release_manifest.json"}},"DDX11-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX11-AS1","identifiers":{"aliases":["CONCR","SCAT4"],"approved_symbol":"DDX11-AS1","ensembl_gene_id":"ENSG00000245614","hgnc_id":"HGNC:44176","ncbi_gene_id":100506660,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX11-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DDX17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX17","identifiers":{"aliases":["P72"],"approved_symbol":"DDX17","ensembl_gene_id":"ENSG00000100201","hgnc_id":"HGNC:2740","ncbi_gene_id":10521,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX17","release_manifest":"api/v1.1/release_manifest.json"}},"DDX18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX18","identifiers":{"aliases":["MrDb","Has1"],"approved_symbol":"DDX18","ensembl_gene_id":"ENSG00000088205","hgnc_id":"HGNC:2741","ncbi_gene_id":8886,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX18","release_manifest":"api/v1.1/release_manifest.json"}},"DDX19A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX19A","identifiers":{"aliases":["FLJ11126"],"approved_symbol":"DDX19A","ensembl_gene_id":"ENSG00000168872","hgnc_id":"HGNC:25628","ncbi_gene_id":55308,"previous_symbols":["DDX19L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.10016,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX19A","release_manifest":"api/v1.1/release_manifest.json"}},"DDX19B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX19B","identifiers":{"aliases":["DBP5"],"approved_symbol":"DDX19B","ensembl_gene_id":"ENSG00000157349","hgnc_id":"HGNC:2742","ncbi_gene_id":11269,"previous_symbols":["DDX19"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":145},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.069099,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"computational_replication","current_display_label":"Computational replication","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":9,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-07","label":"Independent computational replication is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-03 DMD-relevant functional validation"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":7.22865,"depmap_median_gene_effect":-0.2124403835409793,"moderate_dependency_flag":false,"observed_counteralignment":0.0181322540721587},"summary":"Priority B · multisource follow-up; observed DMD-prior counteralignment 0.0181; observed cells 145; integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX19B","detailed_audit_record":"gene/DDX19B/audit","legacy_api_record":"api/v1/genes/DDX19B.json","release_manifest":"api/v1.1/release_manifest.json"}},"DDX20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX20","identifiers":{"aliases":["DP103","GEMIN3"],"approved_symbol":"DDX20","ensembl_gene_id":"ENSG00000064703","hgnc_id":"HGNC:2743","ncbi_gene_id":11218,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX20","release_manifest":"api/v1.1/release_manifest.json"}},"DDX21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX21","identifiers":{"aliases":["RH-II/GU","GURDB","Gu-alpha"],"approved_symbol":"DDX21","ensembl_gene_id":"ENSG00000165732","hgnc_id":"HGNC:2744","ncbi_gene_id":9188,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX21","release_manifest":"api/v1.1/release_manifest.json"}},"DDX23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX23","identifiers":{"aliases":["Prp28","U5-100KD","PRPF28","SNRNP100"],"approved_symbol":"DDX23","ensembl_gene_id":"ENSG00000174243","hgnc_id":"HGNC:17347","ncbi_gene_id":9416,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX23","release_manifest":"api/v1.1/release_manifest.json"}},"DDX24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX24","identifiers":{"aliases":[],"approved_symbol":"DDX24","ensembl_gene_id":"ENSG00000089737","hgnc_id":"HGNC:13266","ncbi_gene_id":57062,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX24","release_manifest":"api/v1.1/release_manifest.json"}},"DDX25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX25","identifiers":{"aliases":["GRTH"],"approved_symbol":"DDX25","ensembl_gene_id":"ENSG00000109832","hgnc_id":"HGNC:18698","ncbi_gene_id":29118,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DDX25","release_manifest":"api/v1.1/release_manifest.json"}},"DDX27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX27","identifiers":{"aliases":["dJ686N3.1","DRS1"],"approved_symbol":"DDX27","ensembl_gene_id":"ENSG00000124228","hgnc_id":"HGNC:15837","ncbi_gene_id":55661,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX27","release_manifest":"api/v1.1/release_manifest.json"}},"DDX28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX28","identifiers":{"aliases":["MDDX28","FLJ11282"],"approved_symbol":"DDX28","ensembl_gene_id":"ENSG00000182810","hgnc_id":"HGNC:17330","ncbi_gene_id":55794,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX28","release_manifest":"api/v1.1/release_manifest.json"}},"DDX31":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX31","identifiers":{"aliases":["FLJ13633","FLJ23349","FLJ14578","PPP1R25"],"approved_symbol":"DDX31","ensembl_gene_id":"ENSG00000125485","hgnc_id":"HGNC:16715","ncbi_gene_id":64794,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX31","release_manifest":"api/v1.1/release_manifest.json"}},"DDX39A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX39A","identifiers":{"aliases":["DDXL","BAT1L","URH49"],"approved_symbol":"DDX39A","ensembl_gene_id":"ENSG00000123136","hgnc_id":"HGNC:17821","ncbi_gene_id":10212,"previous_symbols":["DDX39"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX39A","release_manifest":"api/v1.1/release_manifest.json"}},"DDX39B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX39B","identifiers":{"aliases":["D6S81E","Uap56"],"approved_symbol":"DDX39B","ensembl_gene_id":"ENSG00000198563","hgnc_id":"HGNC:13917","ncbi_gene_id":7919,"previous_symbols":["BAT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX39B","release_manifest":"api/v1.1/release_manifest.json"}},"DDX3X":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX3X","identifiers":{"aliases":["DBX","HLP2","DDX14","CAP-Rf"],"approved_symbol":"DDX3X","ensembl_gene_id":"ENSG00000215301","hgnc_id":"HGNC:2745","ncbi_gene_id":1654,"previous_symbols":["DDX3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX3X","release_manifest":"api/v1.1/release_manifest.json"}},"DDX3Y":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX3Y","identifiers":{"aliases":[],"approved_symbol":"DDX3Y","ensembl_gene_id":"ENSG00000067048","hgnc_id":"HGNC:2699","ncbi_gene_id":8653,"previous_symbols":["DBY"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX3Y","release_manifest":"api/v1.1/release_manifest.json"}},"DDX4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX4","identifiers":{"aliases":["VASA"],"approved_symbol":"DDX4","ensembl_gene_id":"ENSG00000152670","hgnc_id":"HGNC:18700","ncbi_gene_id":54514,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DDX4","release_manifest":"api/v1.1/release_manifest.json"}},"DDX41":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX41","identifiers":{"aliases":["ABS","MGC8828"],"approved_symbol":"DDX41","ensembl_gene_id":"ENSG00000183258","hgnc_id":"HGNC:18674","ncbi_gene_id":51428,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX41","release_manifest":"api/v1.1/release_manifest.json"}},"DDX42":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX42","identifiers":{"aliases":["RNAHP","RHELP","SF3b125","SF3B8"],"approved_symbol":"DDX42","ensembl_gene_id":"ENSG00000198231","hgnc_id":"HGNC:18676","ncbi_gene_id":11325,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX42","release_manifest":"api/v1.1/release_manifest.json"}},"DDX43":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX43","identifiers":{"aliases":["HAGE","DKFZp434H2114","CT13"],"approved_symbol":"DDX43","ensembl_gene_id":"ENSG00000080007","hgnc_id":"HGNC:18677","ncbi_gene_id":55510,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX43","release_manifest":"api/v1.1/release_manifest.json"}},"DDX46":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX46","identifiers":{"aliases":["KIAA0801","FLJ25329","PRPF5","Prp5"],"approved_symbol":"DDX46","ensembl_gene_id":"ENSG00000145833","hgnc_id":"HGNC:18681","ncbi_gene_id":9879,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX46","release_manifest":"api/v1.1/release_manifest.json"}},"DDX47":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX47","identifiers":{"aliases":["DKFZp564O176","FLJ30012","HQ0256","RRP3"],"approved_symbol":"DDX47","ensembl_gene_id":"ENSG00000213782","hgnc_id":"HGNC:18682","ncbi_gene_id":51202,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX47","release_manifest":"api/v1.1/release_manifest.json"}},"DDX49":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX49","identifiers":{"aliases":["FLJ10432","Dbp8"],"approved_symbol":"DDX49","ensembl_gene_id":"ENSG00000105671","hgnc_id":"HGNC:18684","ncbi_gene_id":54555,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX49","release_manifest":"api/v1.1/release_manifest.json"}},"DDX5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX5","identifiers":{"aliases":["p68"],"approved_symbol":"DDX5","ensembl_gene_id":"ENSG00000108654","hgnc_id":"HGNC:2746","ncbi_gene_id":1655,"previous_symbols":["HLR1","G17P1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX5","release_manifest":"api/v1.1/release_manifest.json"}},"DDX50":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX50","identifiers":{"aliases":["GU2","MGC3199","GUB","RH-II/GuB"],"approved_symbol":"DDX50","ensembl_gene_id":"ENSG00000107625","hgnc_id":"HGNC:17906","ncbi_gene_id":79009,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX50","release_manifest":"api/v1.1/release_manifest.json"}},"DDX51":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX51","identifiers":{"aliases":[],"approved_symbol":"DDX51","ensembl_gene_id":"ENSG00000185163","hgnc_id":"HGNC:20082","ncbi_gene_id":317781,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX51","release_manifest":"api/v1.1/release_manifest.json"}},"DDX52":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX52","identifiers":{"aliases":["ROK1"],"approved_symbol":"DDX52","ensembl_gene_id":"ENSG00000278053","hgnc_id":"HGNC:20038","ncbi_gene_id":11056,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX52","release_manifest":"api/v1.1/release_manifest.json"}},"DDX54":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX54","identifiers":{"aliases":["MGC2835","APR-5","DP97"],"approved_symbol":"DDX54","ensembl_gene_id":"ENSG00000123064","hgnc_id":"HGNC:20084","ncbi_gene_id":79039,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX54","release_manifest":"api/v1.1/release_manifest.json"}},"DDX55":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX55","identifiers":{"aliases":["KIAA1595"],"approved_symbol":"DDX55","ensembl_gene_id":"ENSG00000111364","hgnc_id":"HGNC:20085","ncbi_gene_id":57696,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX55","release_manifest":"api/v1.1/release_manifest.json"}},"DDX56":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX56","identifiers":{"aliases":["NOH61"],"approved_symbol":"DDX56","ensembl_gene_id":"ENSG00000136271","hgnc_id":"HGNC:18193","ncbi_gene_id":54606,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DDX56","release_manifest":"api/v1.1/release_manifest.json"}},"DDX58":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX58","identifiers":{"approved_symbol":"DDX58","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DDX58","release_manifest":"api/v1.1/release_manifest.json"}},"DDX59":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX59","identifiers":{"aliases":["DKFZP564B1023","ZNHIT5"],"approved_symbol":"DDX59","ensembl_gene_id":"ENSG00000118197","hgnc_id":"HGNC:25360","ncbi_gene_id":83479,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX59","release_manifest":"api/v1.1/release_manifest.json"}},"DDX59-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX59-AS1","identifiers":{"aliases":[],"approved_symbol":"DDX59-AS1","ensembl_gene_id":"ENSG00000260088","hgnc_id":"HGNC:41094","ncbi_gene_id":101929224,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DDX59-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DDX6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX6","identifiers":{"aliases":["RCK","Rck/p54"],"approved_symbol":"DDX6","ensembl_gene_id":"ENSG00000110367","hgnc_id":"HGNC:2747","ncbi_gene_id":1656,"previous_symbols":["HLR2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX6","release_manifest":"api/v1.1/release_manifest.json"}},"DDX60":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX60","identifiers":{"aliases":["FLJ20035"],"approved_symbol":"DDX60","ensembl_gene_id":"ENSG00000137628","hgnc_id":"HGNC:25942","ncbi_gene_id":55601,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DDX60","release_manifest":"api/v1.1/release_manifest.json"}},"DDX60L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DDX60L","identifiers":{"aliases":["FLJ31033"],"approved_symbol":"DDX60L","ensembl_gene_id":"ENSG00000181381","hgnc_id":"HGNC:26429","ncbi_gene_id":91351,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DDX60L","release_manifest":"api/v1.1/release_manifest.json"}},"DEAF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEAF1","identifiers":{"aliases":["NUDR","SPN","ZMYND5"],"approved_symbol":"DEAF1","ensembl_gene_id":"ENSG00000177030","hgnc_id":"HGNC:14677","ncbi_gene_id":10522,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DEAF1","release_manifest":"api/v1.1/release_manifest.json"}},"DECR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DECR1","identifiers":{"aliases":["SDR18C1"],"approved_symbol":"DECR1","ensembl_gene_id":"ENSG00000104325","hgnc_id":"HGNC:2753","ncbi_gene_id":1666,"previous_symbols":["DECR"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DECR1","release_manifest":"api/v1.1/release_manifest.json"}},"DECR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DECR2","identifiers":{"aliases":["PDCR","SDR17C1"],"approved_symbol":"DECR2","ensembl_gene_id":"ENSG00000242612","hgnc_id":"HGNC:2754","ncbi_gene_id":26063,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DECR2","release_manifest":"api/v1.1/release_manifest.json"}},"DEDD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEDD","identifiers":{"aliases":["DEFT","FLDED1","CASP8IP1","KE05","DEDD1"],"approved_symbol":"DEDD","ensembl_gene_id":"ENSG00000158796","hgnc_id":"HGNC:2755","ncbi_gene_id":9191,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEDD","release_manifest":"api/v1.1/release_manifest.json"}},"DEDD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEDD2","identifiers":{"aliases":["FLAME-3"],"approved_symbol":"DEDD2","ensembl_gene_id":"ENSG00000160570","hgnc_id":"HGNC:24450","ncbi_gene_id":162989,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEDD2","release_manifest":"api/v1.1/release_manifest.json"}},"DEF6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEF6","identifiers":{"aliases":["IBP","SLAT","SWAP70L"],"approved_symbol":"DEF6","ensembl_gene_id":"ENSG00000023892","hgnc_id":"HGNC:2760","ncbi_gene_id":50619,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEF6","release_manifest":"api/v1.1/release_manifest.json"}},"DEF8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEF8","identifiers":{"aliases":["FLJ20186"],"approved_symbol":"DEF8","ensembl_gene_id":"ENSG00000140995","hgnc_id":"HGNC:25969","ncbi_gene_id":54849,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEF8","release_manifest":"api/v1.1/release_manifest.json"}},"DEFB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEFB1","identifiers":{"aliases":["HBD-1","DEFB-1","DEFB101","HBD1","BD1","MGC51822"],"approved_symbol":"DEFB1","ensembl_gene_id":"ENSG00000164825","hgnc_id":"HGNC:2766","ncbi_gene_id":1672,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DEFB1","release_manifest":"api/v1.1/release_manifest.json"}},"DEFB119":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEFB119","identifiers":{"aliases":["DEFB-19","DEFB-20"],"approved_symbol":"DEFB119","ensembl_gene_id":"ENSG00000180483","hgnc_id":"HGNC:18099","ncbi_gene_id":245932,"previous_symbols":["DEFB120"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DEFB119","release_manifest":"api/v1.1/release_manifest.json"}},"DEFB124":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEFB124","identifiers":{"aliases":["DEFB-24"],"approved_symbol":"DEFB124","ensembl_gene_id":"ENSG00000180383","hgnc_id":"HGNC:18104","ncbi_gene_id":245937,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEFB124","release_manifest":"api/v1.1/release_manifest.json"}},"DEGS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEGS1","identifiers":{"aliases":["MLD","Des-1","DES1","FADS7","DEGS-1"],"approved_symbol":"DEGS1","ensembl_gene_id":"ENSG00000143753","hgnc_id":"HGNC:13709","ncbi_gene_id":8560,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEGS1","release_manifest":"api/v1.1/release_manifest.json"}},"DEGS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEGS2","identifiers":{"aliases":["DES2","FADS8"],"approved_symbol":"DEGS2","ensembl_gene_id":"ENSG00000168350","hgnc_id":"HGNC:20113","ncbi_gene_id":123099,"previous_symbols":["C14orf66"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEGS2","release_manifest":"api/v1.1/release_manifest.json"}},"DEK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEK","identifiers":{"aliases":["D6S231E"],"approved_symbol":"DEK","ensembl_gene_id":"ENSG00000124795","hgnc_id":"HGNC:2768","ncbi_gene_id":7913,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEK","release_manifest":"api/v1.1/release_manifest.json"}},"DELE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DELE1","identifiers":{"aliases":["DELE"],"approved_symbol":"DELE1","ensembl_gene_id":"ENSG00000081791","hgnc_id":"HGNC:28969","ncbi_gene_id":9812,"previous_symbols":["KIAA0141"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DELE1","release_manifest":"api/v1.1/release_manifest.json"}},"DENND10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND10","identifiers":{"aliases":[],"approved_symbol":"DENND10","ensembl_gene_id":"ENSG00000119979","hgnc_id":"HGNC:31793","ncbi_gene_id":404636,"previous_symbols":["FAM45A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND10","release_manifest":"api/v1.1/release_manifest.json"}},"DENND11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND11","identifiers":{"aliases":["LCHN"],"approved_symbol":"DENND11","ensembl_gene_id":"ENSG00000257093","hgnc_id":"HGNC:29472","ncbi_gene_id":57189,"previous_symbols":["KIAA1147"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DENND11","release_manifest":"api/v1.1/release_manifest.json"}},"DENND1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND1A","identifiers":{"aliases":["FLJ21129","FAM31A"],"approved_symbol":"DENND1A","ensembl_gene_id":"ENSG00000119522","hgnc_id":"HGNC:29324","ncbi_gene_id":57706,"previous_symbols":["KIAA1608"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND1A","release_manifest":"api/v1.1/release_manifest.json"}},"DENND1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND1B","identifiers":{"aliases":["MGC27044","FLJ20054"],"approved_symbol":"DENND1B","ensembl_gene_id":"ENSG00000213047","hgnc_id":"HGNC:28404","ncbi_gene_id":163486,"previous_symbols":["FAM31B","C1orf218"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND1B","release_manifest":"api/v1.1/release_manifest.json"}},"DENND1C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND1C","identifiers":{"aliases":["FLJ22757"],"approved_symbol":"DENND1C","ensembl_gene_id":"ENSG00000205744","hgnc_id":"HGNC:26225","ncbi_gene_id":79958,"previous_symbols":["FAM31C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND1C","release_manifest":"api/v1.1/release_manifest.json"}},"DENND2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND2A","identifiers":{"aliases":["FAM31D"],"approved_symbol":"DENND2A","ensembl_gene_id":"ENSG00000146966","hgnc_id":"HGNC:22212","ncbi_gene_id":27147,"previous_symbols":["KIAA1277"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND2A","release_manifest":"api/v1.1/release_manifest.json"}},"DENND2C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND2C","identifiers":{"aliases":["FLJ37099","DKFZp686G0351","DKFZp779P1149","dJ1156J9.1","RP5-1156J9.1"],"approved_symbol":"DENND2C","ensembl_gene_id":"ENSG00000175984","hgnc_id":"HGNC:24748","ncbi_gene_id":163259,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DENND2C","release_manifest":"api/v1.1/release_manifest.json"}},"DENND2D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND2D","identifiers":{"aliases":["FLJ22457","RP5-1180E21.2"],"approved_symbol":"DENND2D","ensembl_gene_id":"ENSG00000162777","hgnc_id":"HGNC:26192","ncbi_gene_id":79961,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND2D","release_manifest":"api/v1.1/release_manifest.json"}},"DENND3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND3","identifiers":{"aliases":["KIAA0870"],"approved_symbol":"DENND3","ensembl_gene_id":"ENSG00000105339","hgnc_id":"HGNC:29134","ncbi_gene_id":22898,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND3","release_manifest":"api/v1.1/release_manifest.json"}},"DENND4A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND4A","identifiers":{"aliases":["IRLB"],"approved_symbol":"DENND4A","ensembl_gene_id":"ENSG00000174485","hgnc_id":"HGNC:24321","ncbi_gene_id":10260,"previous_symbols":["MYCPBP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND4A","release_manifest":"api/v1.1/release_manifest.json"}},"DENND4B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND4B","identifiers":{"aliases":[],"approved_symbol":"DENND4B","ensembl_gene_id":"ENSG00000198837","hgnc_id":"HGNC:29044","ncbi_gene_id":9909,"previous_symbols":["KIAA0476"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND4B","release_manifest":"api/v1.1/release_manifest.json"}},"DENND4C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND4C","identifiers":{"aliases":["FLJ20686","bA513M16.3","RAB10GEF"],"approved_symbol":"DENND4C","ensembl_gene_id":"ENSG00000137145","hgnc_id":"HGNC:26079","ncbi_gene_id":55667,"previous_symbols":["C9orf55B","C9orf55"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND4C","release_manifest":"api/v1.1/release_manifest.json"}},"DENND5A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND5A","identifiers":{"aliases":["KIAA1091","FLJ22354","FLJ33829","FLJ43455"],"approved_symbol":"DENND5A","ensembl_gene_id":"ENSG00000184014","hgnc_id":"HGNC:19344","ncbi_gene_id":23258,"previous_symbols":["RAB6IP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND5A","release_manifest":"api/v1.1/release_manifest.json"}},"DENND5B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND5B","identifiers":{"aliases":["MGC24039"],"approved_symbol":"DENND5B","ensembl_gene_id":"ENSG00000170456","hgnc_id":"HGNC:28338","ncbi_gene_id":160518,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND5B","release_manifest":"api/v1.1/release_manifest.json"}},"DENND5B-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND5B-AS1","identifiers":{"aliases":[],"approved_symbol":"DENND5B-AS1","ensembl_gene_id":"ENSG00000255867","hgnc_id":"HGNC:42517","ncbi_gene_id":100874249,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DENND5B-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DENND6A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND6A","identifiers":{"aliases":["FLJ34969","AFI1A"],"approved_symbol":"DENND6A","ensembl_gene_id":"ENSG00000174839","hgnc_id":"HGNC:26635","ncbi_gene_id":201627,"previous_symbols":["FAM116A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND6A","release_manifest":"api/v1.1/release_manifest.json"}},"DENND6A-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND6A-AS1","identifiers":{"aliases":[],"approved_symbol":"DENND6A-AS1","ensembl_gene_id":"ENSG00000239801","hgnc_id":"HGNC:41152","ncbi_gene_id":106144528,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND6A-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DENND6B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENND6B","identifiers":{"aliases":["MGC33692","AFI1B"],"approved_symbol":"DENND6B","ensembl_gene_id":"ENSG00000205593","hgnc_id":"HGNC:32690","ncbi_gene_id":414918,"previous_symbols":["FAM116B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENND6B","release_manifest":"api/v1.1/release_manifest.json"}},"DENR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DENR","identifiers":{"aliases":["DRP","DRP1","SMAP-3"],"approved_symbol":"DENR","ensembl_gene_id":"ENSG00000139726","hgnc_id":"HGNC:2769","ncbi_gene_id":8562,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DENR","release_manifest":"api/v1.1/release_manifest.json"}},"DEPDC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPDC1","identifiers":{"aliases":["DEP.8","FLJ20354","SDP35","DEPDC1A"],"approved_symbol":"DEPDC1","ensembl_gene_id":"ENSG00000024526","hgnc_id":"HGNC:22949","ncbi_gene_id":55635,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPDC1","release_manifest":"api/v1.1/release_manifest.json"}},"DEPDC1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPDC1B","identifiers":{"aliases":["XTP1","BRCC3"],"approved_symbol":"DEPDC1B","ensembl_gene_id":"ENSG00000035499","hgnc_id":"HGNC:24902","ncbi_gene_id":55789,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPDC1B","release_manifest":"api/v1.1/release_manifest.json"}},"DEPDC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPDC4","identifiers":{"aliases":["DEP.4","FLJ33505"],"approved_symbol":"DEPDC4","ensembl_gene_id":"ENSG00000166153","hgnc_id":"HGNC:22952","ncbi_gene_id":120863,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPDC4","release_manifest":"api/v1.1/release_manifest.json"}},"DEPDC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPDC5","identifiers":{"aliases":["KIAA0645","DEP.5"],"approved_symbol":"DEPDC5","ensembl_gene_id":"ENSG00000100150","hgnc_id":"HGNC:18423","ncbi_gene_id":9681,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPDC5","release_manifest":"api/v1.1/release_manifest.json"}},"DEPDC7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPDC7","identifiers":{"aliases":[],"approved_symbol":"DEPDC7","ensembl_gene_id":"ENSG00000121690","hgnc_id":"HGNC:29899","ncbi_gene_id":91614,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPDC7","release_manifest":"api/v1.1/release_manifest.json"}},"DEPP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPP1","identifiers":{"aliases":["DEPP","FIG","Fseg"],"approved_symbol":"DEPP1","ensembl_gene_id":"ENSG00000165507","hgnc_id":"HGNC:23355","ncbi_gene_id":11067,"previous_symbols":["C10orf10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPP1","release_manifest":"api/v1.1/release_manifest.json"}},"DEPTOR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEPTOR","identifiers":{"aliases":["DEP.6","FLJ12428"],"approved_symbol":"DEPTOR","ensembl_gene_id":"ENSG00000155792","hgnc_id":"HGNC:22953","ncbi_gene_id":64798,"previous_symbols":["DEPDC6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEPTOR","release_manifest":"api/v1.1/release_manifest.json"}},"DERA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DERA","identifiers":{"aliases":["CGI-26","DEOC"],"approved_symbol":"DERA","ensembl_gene_id":"ENSG00000023697","hgnc_id":"HGNC:24269","ncbi_gene_id":51071,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DERA","release_manifest":"api/v1.1/release_manifest.json"}},"DERL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DERL1","identifiers":{"aliases":["MGC3067","PRO2577","FLJ13784","DER1","DER-1","derlin-1"],"approved_symbol":"DERL1","ensembl_gene_id":"ENSG00000136986","hgnc_id":"HGNC:28454","ncbi_gene_id":79139,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DERL1","release_manifest":"api/v1.1/release_manifest.json"}},"DERL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DERL2","identifiers":{"aliases":["F-LAN-1","FLANa","F-LANa","CGI-101","derlin-2"],"approved_symbol":"DERL2","ensembl_gene_id":"ENSG00000072849","hgnc_id":"HGNC:17943","ncbi_gene_id":51009,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.28267,"fdr":0.554932,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DERL2","release_manifest":"api/v1.1/release_manifest.json"}},"DERL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DERL3","identifiers":{"aliases":["FLJ43842","MGC71803","derlin-3","IZP6"],"approved_symbol":"DERL3","ensembl_gene_id":"ENSG00000099958","hgnc_id":"HGNC:14236","ncbi_gene_id":91319,"previous_symbols":["C22orf14"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DERL3","release_manifest":"api/v1.1/release_manifest.json"}},"DES":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DES","identifiers":{"aliases":["CMD1I","CSM1","CSM2","LGMD2R"],"approved_symbol":"DES","ensembl_gene_id":"ENSG00000175084","hgnc_id":"HGNC:2770","ncbi_gene_id":1674,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/DES","release_manifest":"api/v1.1/release_manifest.json"}},"DESI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DESI1","identifiers":{"aliases":["D15Wsu75e","DESI-1","POST"],"approved_symbol":"DESI1","ensembl_gene_id":"ENSG00000100418","hgnc_id":"HGNC:24577","ncbi_gene_id":27351,"previous_symbols":["FAM152B","PPPDE2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.16738,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DESI1","release_manifest":"api/v1.1/release_manifest.json"}},"DESI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DESI2","identifiers":{"aliases":["CGI-146","FLJ21998","PNAS-4","DESI-2"],"approved_symbol":"DESI2","ensembl_gene_id":"ENSG00000121644","hgnc_id":"HGNC:24264","ncbi_gene_id":51029,"previous_symbols":["C1orf121","FAM152A","PPPDE1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DESI2","release_manifest":"api/v1.1/release_manifest.json"}},"DET1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DET1","identifiers":{"aliases":["FLJ10103"],"approved_symbol":"DET1","ensembl_gene_id":"ENSG00000140543","hgnc_id":"HGNC:25477","ncbi_gene_id":55070,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DET1","release_manifest":"api/v1.1/release_manifest.json"}},"DEUP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEUP1","identifiers":{"aliases":["FLJ25393"],"approved_symbol":"DEUP1","ensembl_gene_id":"ENSG00000165325","hgnc_id":"HGNC:26344","ncbi_gene_id":159989,"previous_symbols":["CCDC67"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEUP1","release_manifest":"api/v1.1/release_manifest.json"}},"DEXI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DEXI","identifiers":{"aliases":["MYLE"],"approved_symbol":"DEXI","ensembl_gene_id":"ENSG00000182108","hgnc_id":"HGNC:13267","ncbi_gene_id":28955,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DEXI","release_manifest":"api/v1.1/release_manifest.json"}},"DFFA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DFFA","identifiers":{"aliases":["DFF-45","DFF45","ICAD","DFF1"],"approved_symbol":"DFFA","ensembl_gene_id":"ENSG00000160049","hgnc_id":"HGNC:2772","ncbi_gene_id":1676,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DFFA","release_manifest":"api/v1.1/release_manifest.json"}},"DFFB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DFFB","identifiers":{"aliases":["CAD","CPAN","DFF-40","DFF40"],"approved_symbol":"DFFB","ensembl_gene_id":"ENSG00000169598","hgnc_id":"HGNC:2773","ncbi_gene_id":1677,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DFFB","release_manifest":"api/v1.1/release_manifest.json"}},"DGAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGAT1","identifiers":{"aliases":["ARGP1"],"approved_symbol":"DGAT1","ensembl_gene_id":"ENSG00000185000","hgnc_id":"HGNC:2843","ncbi_gene_id":8694,"previous_symbols":["DGAT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGAT1","release_manifest":"api/v1.1/release_manifest.json"}},"DGAT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGAT2","identifiers":{"aliases":[],"approved_symbol":"DGAT2","ensembl_gene_id":"ENSG00000062282","hgnc_id":"HGNC:16940","ncbi_gene_id":84649,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGAT2","release_manifest":"api/v1.1/release_manifest.json"}},"DGAT2L6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGAT2L6","identifiers":{"aliases":["DC3","FLJ25989"],"approved_symbol":"DGAT2L6","ensembl_gene_id":"ENSG00000184210","hgnc_id":"HGNC:23250","ncbi_gene_id":347516,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DGAT2L6","release_manifest":"api/v1.1/release_manifest.json"}},"DGCR11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGCR11","identifiers":{"aliases":["DGS-D"],"approved_symbol":"DGCR11","ensembl_gene_id":"ENSG00000273311","hgnc_id":"HGNC:17226","ncbi_gene_id":25786,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DGCR11","release_manifest":"api/v1.1/release_manifest.json"}},"DGCR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGCR2","identifiers":{"aliases":["KIAA0163","LAN","IDD","DGS-C","SEZ-12"],"approved_symbol":"DGCR2","ensembl_gene_id":"ENSG00000070413","hgnc_id":"HGNC:2845","ncbi_gene_id":9993,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGCR2","release_manifest":"api/v1.1/release_manifest.json"}},"DGCR6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGCR6","identifiers":{"aliases":[],"approved_symbol":"DGCR6","ensembl_gene_id":"ENSG00000183628","hgnc_id":"HGNC:2846","ncbi_gene_id":8214,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGCR6","release_manifest":"api/v1.1/release_manifest.json"}},"DGCR6L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGCR6L","identifiers":{"aliases":["FLJ10666"],"approved_symbol":"DGCR6L","ensembl_gene_id":"ENSG00000128185","hgnc_id":"HGNC:18551","ncbi_gene_id":85359,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGCR6L","release_manifest":"api/v1.1/release_manifest.json"}},"DGCR8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGCR8","identifiers":{"aliases":["DGCRK6","Gy1","pasha"],"approved_symbol":"DGCR8","ensembl_gene_id":"ENSG00000128191","hgnc_id":"HGNC:2847","ncbi_gene_id":54487,"previous_symbols":["C22orf12"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGCR8","release_manifest":"api/v1.1/release_manifest.json"}},"DGKA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKA","identifiers":{"aliases":["DGK-alpha"],"approved_symbol":"DGKA","ensembl_gene_id":"ENSG00000065357","hgnc_id":"HGNC:2849","ncbi_gene_id":1606,"previous_symbols":["DAGK","DAGK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKA","release_manifest":"api/v1.1/release_manifest.json"}},"DGKB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKB","identifiers":{"aliases":["KIAA0718","DGK","DGK-BETA"],"approved_symbol":"DGKB","ensembl_gene_id":"ENSG00000136267","hgnc_id":"HGNC:2850","ncbi_gene_id":1607,"previous_symbols":["DAGK2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKB","release_manifest":"api/v1.1/release_manifest.json"}},"DGKD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKD","identifiers":{"aliases":["KIAA0145","DGKdelta"],"approved_symbol":"DGKD","ensembl_gene_id":"ENSG00000077044","hgnc_id":"HGNC:2851","ncbi_gene_id":8527,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKD","release_manifest":"api/v1.1/release_manifest.json"}},"DGKE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKE","identifiers":{"aliases":["DAGK6","DGK"],"approved_symbol":"DGKE","ensembl_gene_id":"ENSG00000153933","hgnc_id":"HGNC:2852","ncbi_gene_id":8526,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKE","release_manifest":"api/v1.1/release_manifest.json"}},"DGKG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKG","identifiers":{"aliases":[],"approved_symbol":"DGKG","ensembl_gene_id":"ENSG00000058866","hgnc_id":"HGNC:2853","ncbi_gene_id":1608,"previous_symbols":["DAGK3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DGKG","release_manifest":"api/v1.1/release_manifest.json"}},"DGKH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKH","identifiers":{"aliases":["DGKeta"],"approved_symbol":"DGKH","ensembl_gene_id":"ENSG00000102780","hgnc_id":"HGNC:2854","ncbi_gene_id":160851,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKH","release_manifest":"api/v1.1/release_manifest.json"}},"DGKI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKI","identifiers":{"aliases":["DGK-IOTA"],"approved_symbol":"DGKI","ensembl_gene_id":"ENSG00000157680","hgnc_id":"HGNC:2855","ncbi_gene_id":9162,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKI","release_manifest":"api/v1.1/release_manifest.json"}},"DGKK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKK","identifiers":{"aliases":[],"approved_symbol":"DGKK","ensembl_gene_id":"ENSG00000274588","hgnc_id":"HGNC:32395","ncbi_gene_id":139189,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DGKK","release_manifest":"api/v1.1/release_manifest.json"}},"DGKQ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKQ","identifiers":{"aliases":["DAGK","DAGK7"],"approved_symbol":"DGKQ","ensembl_gene_id":"ENSG00000145214","hgnc_id":"HGNC:2856","ncbi_gene_id":1609,"previous_symbols":["DAGK4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKQ","release_manifest":"api/v1.1/release_manifest.json"}},"DGKZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGKZ","identifiers":{"aliases":["DAGK5","hDGKzeta","DGK-ZETA","DAGK6"],"approved_symbol":"DGKZ","ensembl_gene_id":"ENSG00000149091","hgnc_id":"HGNC:2857","ncbi_gene_id":8525,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGKZ","release_manifest":"api/v1.1/release_manifest.json"}},"DGLUCY":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGLUCY","identifiers":{"aliases":["FLJ39975"],"approved_symbol":"DGLUCY","ensembl_gene_id":"ENSG00000133943","hgnc_id":"HGNC:20498","ncbi_gene_id":80017,"previous_symbols":["C14orf159"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGLUCY","release_manifest":"api/v1.1/release_manifest.json"}},"DGUOK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGUOK","identifiers":{"aliases":["dGK"],"approved_symbol":"DGUOK","ensembl_gene_id":"ENSG00000114956","hgnc_id":"HGNC:2858","ncbi_gene_id":1716,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DGUOK","release_manifest":"api/v1.1/release_manifest.json"}},"DGUOK-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DGUOK-AS1","identifiers":{"aliases":[],"approved_symbol":"DGUOK-AS1","ensembl_gene_id":"ENSG00000237883","hgnc_id":"HGNC:43441","ncbi_gene_id":100874048,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DGUOK-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DHCR24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHCR24","identifiers":{"aliases":["KIAA0018","seladin-1"],"approved_symbol":"DHCR24","ensembl_gene_id":"ENSG00000116133","hgnc_id":"HGNC:2859","ncbi_gene_id":1718,"previous_symbols":["DCE"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHCR24","release_manifest":"api/v1.1/release_manifest.json"}},"DHCR7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHCR7","identifiers":{"aliases":[],"approved_symbol":"DHCR7","ensembl_gene_id":"ENSG00000172893","hgnc_id":"HGNC:2860","ncbi_gene_id":1717,"previous_symbols":["SLOS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHCR7","release_manifest":"api/v1.1/release_manifest.json"}},"DHDDS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHDDS","identifiers":{"aliases":["HDS","FLJ13102","DS","RP59","hCIT"],"approved_symbol":"DHDDS","ensembl_gene_id":"ENSG00000117682","hgnc_id":"HGNC:20603","ncbi_gene_id":79947,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHDDS","release_manifest":"api/v1.1/release_manifest.json"}},"DHDH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHDH","identifiers":{"aliases":["HUM2DD"],"approved_symbol":"DHDH","ensembl_gene_id":"ENSG00000104808","hgnc_id":"HGNC:17887","ncbi_gene_id":27294,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHDH","release_manifest":"api/v1.1/release_manifest.json"}},"DHFR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHFR","identifiers":{"aliases":["DHFR1"],"approved_symbol":"DHFR","ensembl_gene_id":"ENSG00000228716","hgnc_id":"HGNC:2861","ncbi_gene_id":1719,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DHFR","release_manifest":"api/v1.1/release_manifest.json"}},"DHFR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHFR2","identifiers":{"aliases":["FLJ16119"],"approved_symbol":"DHFR2","ensembl_gene_id":"ENSG00000178700","hgnc_id":"HGNC:27309","ncbi_gene_id":200895,"previous_symbols":["DHFRP4","DHFRL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHFR2","release_manifest":"api/v1.1/release_manifest.json"}},"DHH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHH","identifiers":{"aliases":["HHG-3","MGC35145"],"approved_symbol":"DHH","ensembl_gene_id":"ENSG00000139549","hgnc_id":"HGNC:2865","ncbi_gene_id":50846,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHH","release_manifest":"api/v1.1/release_manifest.json"}},"DHODH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHODH","identifiers":{"aliases":[],"approved_symbol":"DHODH","ensembl_gene_id":"ENSG00000102967","hgnc_id":"HGNC:2867","ncbi_gene_id":1723,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DHODH","release_manifest":"api/v1.1/release_manifest.json"}},"DHPS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHPS","identifiers":{"aliases":["MIG13"],"approved_symbol":"DHPS","ensembl_gene_id":"ENSG00000095059","hgnc_id":"HGNC:2869","ncbi_gene_id":1725,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHPS","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS1","identifiers":{"aliases":["FLJ25430","MGC20204","SDR19C1"],"approved_symbol":"DHRS1","ensembl_gene_id":"ENSG00000157379","hgnc_id":"HGNC:16445","ncbi_gene_id":115817,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS1","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS11","identifiers":{"aliases":["MGC4172","SDR24C1"],"approved_symbol":"DHRS11","ensembl_gene_id":"ENSG00000278535","hgnc_id":"HGNC:28639","ncbi_gene_id":79154,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS11","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS12","identifiers":{"aliases":["FLJ13639","SDR40C1"],"approved_symbol":"DHRS12","ensembl_gene_id":"ENSG00000102796","hgnc_id":"HGNC:25832","ncbi_gene_id":79758,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS12","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS13","identifiers":{"aliases":["MGC23280","SDR7C5"],"approved_symbol":"DHRS13","ensembl_gene_id":"ENSG00000167536","hgnc_id":"HGNC:28326","ncbi_gene_id":147015,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS13","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS2","identifiers":{"aliases":["HEP27","SDR25C1"],"approved_symbol":"DHRS2","ensembl_gene_id":"ENSG00000100867","hgnc_id":"HGNC:18349","ncbi_gene_id":10202,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DHRS2","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS3","identifiers":{"aliases":["retSDR1","Rsdr1","SDR1","RDH17","SDR16C1","CNALPTC1"],"approved_symbol":"DHRS3","ensembl_gene_id":"ENSG00000162496","hgnc_id":"HGNC:17693","ncbi_gene_id":9249,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS3","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS4","identifiers":{"aliases":["SCAD-SRL","SDR-SRL","humNRDR","FLJ11008","SDR25C2"],"approved_symbol":"DHRS4","ensembl_gene_id":"ENSG00000157326","hgnc_id":"HGNC:16985","ncbi_gene_id":10901,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DHRS4","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS4-AS1","identifiers":{"aliases":["PRO1488","AS1DHRS4"],"approved_symbol":"DHRS4-AS1","ensembl_gene_id":"ENSG00000215256","hgnc_id":"HGNC:23175","ncbi_gene_id":55449,"previous_symbols":["C14orf167"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS4L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS4L2","identifiers":{"aliases":["SDR25C3"],"approved_symbol":"DHRS4L2","ensembl_gene_id":"ENSG00000187630","hgnc_id":"HGNC:19731","ncbi_gene_id":317749,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS4L2","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS7","identifiers":{"aliases":["retDSR4","SDR34C1"],"approved_symbol":"DHRS7","ensembl_gene_id":"ENSG00000100612","hgnc_id":"HGNC:21524","ncbi_gene_id":51635,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS7","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS7B","identifiers":{"aliases":["DKFZp566O084","MGC8916","CGI-93","SDR32C1"],"approved_symbol":"DHRS7B","ensembl_gene_id":"ENSG00000109016","hgnc_id":"HGNC:24547","ncbi_gene_id":25979,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRS7B","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS7C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS7C","identifiers":{"aliases":["SDR32C2"],"approved_symbol":"DHRS7C","ensembl_gene_id":"ENSG00000184544","hgnc_id":"HGNC:32423","ncbi_gene_id":201140,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DHRS7C","release_manifest":"api/v1.1/release_manifest.json"}},"DHRS9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRS9","identifiers":{"aliases":["RDHL","3alpha-HSD","RETSDR8","RDH15","SDR9C4"],"approved_symbol":"DHRS9","ensembl_gene_id":"ENSG00000073737","hgnc_id":"HGNC:16888","ncbi_gene_id":10170,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DHRS9","release_manifest":"api/v1.1/release_manifest.json"}},"DHRSX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHRSX","identifiers":{"aliases":["DHRS5X","DHRSXY","DHRSY","DHRS5Y","SDR46C1","SDR7C6"],"approved_symbol":"DHRSX","ensembl_gene_id":"ENSG00000169084","hgnc_id":"HGNC:18399","ncbi_gene_id":207063,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHRSX","release_manifest":"api/v1.1/release_manifest.json"}},"DHTKD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHTKD1","identifiers":{"aliases":["KIAA1630","MGC3090","DKFZP762M115","CMT2Q","OADC-E1","OADH-E1","E1a"],"approved_symbol":"DHTKD1","ensembl_gene_id":"ENSG00000181192","hgnc_id":"HGNC:23537","ncbi_gene_id":55526,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHTKD1","release_manifest":"api/v1.1/release_manifest.json"}},"DHX15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX15","identifiers":{"aliases":["HRH2","DBP1","Prp43","PrPp43p","PRPF43"],"approved_symbol":"DHX15","ensembl_gene_id":"ENSG00000109606","hgnc_id":"HGNC:2738","ncbi_gene_id":1665,"previous_symbols":["DDX15"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX15","release_manifest":"api/v1.1/release_manifest.json"}},"DHX16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX16","identifiers":{"aliases":["DBP2","Prp2","PRPF2"],"approved_symbol":"DHX16","ensembl_gene_id":"ENSG00000204560","hgnc_id":"HGNC:2739","ncbi_gene_id":8449,"previous_symbols":["DDX16"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX16","release_manifest":"api/v1.1/release_manifest.json"}},"DHX29":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX29","identifiers":{"aliases":[],"approved_symbol":"DHX29","ensembl_gene_id":"ENSG00000067248","hgnc_id":"HGNC:15815","ncbi_gene_id":54505,"previous_symbols":["DDX29"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.14704,"fdr":0.558831,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX29","release_manifest":"api/v1.1/release_manifest.json"}},"DHX30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX30","identifiers":{"aliases":["KIAA0890","FLJ11214"],"approved_symbol":"DHX30","ensembl_gene_id":"ENSG00000132153","hgnc_id":"HGNC:16716","ncbi_gene_id":22907,"previous_symbols":["DDX30"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.083101,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX30","release_manifest":"api/v1.1/release_manifest.json"}},"DHX32":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX32","identifiers":{"aliases":["FLJ10889","FLJ10694","DHLP1"],"approved_symbol":"DHX32","ensembl_gene_id":"ENSG00000089876","hgnc_id":"HGNC:16717","ncbi_gene_id":55760,"previous_symbols":["DDX32"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX32","release_manifest":"api/v1.1/release_manifest.json"}},"DHX33":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX33","identifiers":{"aliases":["FLJ21972","DKFZp762F2011"],"approved_symbol":"DHX33","ensembl_gene_id":"ENSG00000005100","hgnc_id":"HGNC:16718","ncbi_gene_id":56919,"previous_symbols":["DDX33"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX33","release_manifest":"api/v1.1/release_manifest.json"}},"DHX34":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX34","identifiers":{"aliases":["KIAA0134"],"approved_symbol":"DHX34","ensembl_gene_id":"ENSG00000134815","hgnc_id":"HGNC:16719","ncbi_gene_id":9704,"previous_symbols":["DDX34"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX34","release_manifest":"api/v1.1/release_manifest.json"}},"DHX35":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX35","identifiers":{"aliases":["FLJ22759","KAIA0875"],"approved_symbol":"DHX35","ensembl_gene_id":"ENSG00000101452","hgnc_id":"HGNC:15861","ncbi_gene_id":60625,"previous_symbols":["C20orf15","DDX35"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX35","release_manifest":"api/v1.1/release_manifest.json"}},"DHX36":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX36","identifiers":{"aliases":["MLEL1","KIAA1488","RHAU"],"approved_symbol":"DHX36","ensembl_gene_id":"ENSG00000174953","hgnc_id":"HGNC:14410","ncbi_gene_id":170506,"previous_symbols":["DDX36"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX36","release_manifest":"api/v1.1/release_manifest.json"}},"DHX37":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX37","identifiers":{"aliases":["KIAA1517","MGC4322","MGC2695","Dhr1"],"approved_symbol":"DHX37","ensembl_gene_id":"ENSG00000150990","hgnc_id":"HGNC:17210","ncbi_gene_id":57647,"previous_symbols":["DDX37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX37","release_manifest":"api/v1.1/release_manifest.json"}},"DHX38":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX38","identifiers":{"aliases":["Prp16","KIAA0224","hPrp16","PRPF16"],"approved_symbol":"DHX38","ensembl_gene_id":"ENSG00000140829","hgnc_id":"HGNC:17211","ncbi_gene_id":9785,"previous_symbols":["DDX38"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX38","release_manifest":"api/v1.1/release_manifest.json"}},"DHX40":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX40","identifiers":{"aliases":["ARG147","PAD","FLJ22060"],"approved_symbol":"DHX40","ensembl_gene_id":"ENSG00000108406","hgnc_id":"HGNC:18018","ncbi_gene_id":79665,"previous_symbols":["DDX40"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DHX40","release_manifest":"api/v1.1/release_manifest.json"}},"DHX57":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX57","identifiers":{"aliases":["DDX57"],"approved_symbol":"DHX57","ensembl_gene_id":"ENSG00000163214","hgnc_id":"HGNC:20086","ncbi_gene_id":90957,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX57","release_manifest":"api/v1.1/release_manifest.json"}},"DHX58":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX58","identifiers":{"aliases":["LGP2","D11LGP2"],"approved_symbol":"DHX58","ensembl_gene_id":"ENSG00000108771","hgnc_id":"HGNC:29517","ncbi_gene_id":79132,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX58","release_manifest":"api/v1.1/release_manifest.json"}},"DHX8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX8","identifiers":{"aliases":["HRH1","Prp22","PRPF22","Dhr2"],"approved_symbol":"DHX8","ensembl_gene_id":"ENSG00000067596","hgnc_id":"HGNC:2749","ncbi_gene_id":1659,"previous_symbols":["DDX8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX8","release_manifest":"api/v1.1/release_manifest.json"}},"DHX9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DHX9","identifiers":{"aliases":["RHA"],"approved_symbol":"DHX9","ensembl_gene_id":"ENSG00000135829","hgnc_id":"HGNC:2750","ncbi_gene_id":1660,"previous_symbols":["LKP","DDX9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DHX9","release_manifest":"api/v1.1/release_manifest.json"}},"DIABLO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIABLO","identifiers":{"aliases":["SMAC","DIABLO-S","FLJ25049","FLJ10537","DFNA64"],"approved_symbol":"DIABLO","ensembl_gene_id":"ENSG00000184047","hgnc_id":"HGNC:21528","ncbi_gene_id":56616,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIABLO","release_manifest":"api/v1.1/release_manifest.json"}},"DIAPH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIAPH1","identifiers":{"aliases":["hDIA1","LFHL1","mDia1"],"approved_symbol":"DIAPH1","ensembl_gene_id":"ENSG00000131504","hgnc_id":"HGNC:2876","ncbi_gene_id":1729,"previous_symbols":["DFNA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIAPH1","release_manifest":"api/v1.1/release_manifest.json"}},"DIAPH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIAPH2","identifiers":{"aliases":["POF","DIA","POF2","DIA2"],"approved_symbol":"DIAPH2","ensembl_gene_id":"ENSG00000147202","hgnc_id":"HGNC:2877","ncbi_gene_id":1730,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIAPH2","release_manifest":"api/v1.1/release_manifest.json"}},"DIAPH2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIAPH2-AS1","identifiers":{"aliases":[],"approved_symbol":"DIAPH2-AS1","ensembl_gene_id":"ENSG00000236256","hgnc_id":"HGNC:16972","ncbi_gene_id":10824,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIAPH2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DIAPH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIAPH3","identifiers":{"aliases":["DRF3","FLJ34705","AN","NSDAN"],"approved_symbol":"DIAPH3","ensembl_gene_id":"ENSG00000139734","hgnc_id":"HGNC:15480","ncbi_gene_id":81624,"previous_symbols":["AUNA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIAPH3","release_manifest":"api/v1.1/release_manifest.json"}},"DICER1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DICER1","identifiers":{"aliases":["Dicer","KIAA0928","K12H4.8-LIKE","HERNA"],"approved_symbol":"DICER1","ensembl_gene_id":"ENSG00000100697","hgnc_id":"HGNC:17098","ncbi_gene_id":23405,"previous_symbols":["MNG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DICER1","release_manifest":"api/v1.1/release_manifest.json"}},"DICER1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DICER1-AS1","identifiers":{"aliases":["FLJ45244"],"approved_symbol":"DICER1-AS1","ensembl_gene_id":"ENSG00000235706","hgnc_id":"HGNC:43017","ncbi_gene_id":400242,"previous_symbols":["DICER1-AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DICER1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DIDO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIDO1","identifiers":{"aliases":["DIO1","dJ885L7.8","FLJ11265","KIAA0333","DIO-1","BYE1"],"approved_symbol":"DIDO1","ensembl_gene_id":"ENSG00000101191","hgnc_id":"HGNC:2680","ncbi_gene_id":11083,"previous_symbols":["C20orf158","DATF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIDO1","release_manifest":"api/v1.1/release_manifest.json"}},"DIMT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIMT1","identifiers":{"aliases":["HSA9761"],"approved_symbol":"DIMT1","ensembl_gene_id":"ENSG00000086189","hgnc_id":"HGNC:30217","ncbi_gene_id":27292,"previous_symbols":["DIMT1L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIMT1","release_manifest":"api/v1.1/release_manifest.json"}},"DIO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIO1","identifiers":{"aliases":[],"approved_symbol":"DIO1","ensembl_gene_id":"ENSG00000211452","hgnc_id":"HGNC:2883","ncbi_gene_id":1733,"previous_symbols":["TXDI1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DIO1","release_manifest":"api/v1.1/release_manifest.json"}},"DIO2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIO2","identifiers":{"aliases":["TXDI2","SelY","SELENOY"],"approved_symbol":"DIO2","ensembl_gene_id":"ENSG00000211448","hgnc_id":"HGNC:2884","ncbi_gene_id":1734,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIO2","release_manifest":"api/v1.1/release_manifest.json"}},"DIO2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIO2-AS1","identifiers":{"aliases":[],"approved_symbol":"DIO2-AS1","ensembl_gene_id":"ENSG00000258766","hgnc_id":"HGNC:44153","ncbi_gene_id":100628307,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIO2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DIO3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIO3","identifiers":{"aliases":[],"approved_symbol":"DIO3","ensembl_gene_id":"ENSG00000197406","hgnc_id":"HGNC:2885","ncbi_gene_id":1735,"previous_symbols":["TXDI3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIO3","release_manifest":"api/v1.1/release_manifest.json"}},"DIO3OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIO3OS","identifiers":{"aliases":["NCRNA00041","DIO3-AS1"],"approved_symbol":"DIO3OS","ensembl_gene_id":"ENSG00000258498","hgnc_id":"HGNC:20348","ncbi_gene_id":64150,"previous_symbols":["C14orf134"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIO3OS","release_manifest":"api/v1.1/release_manifest.json"}},"DIP2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIP2A","identifiers":{"aliases":["Dip2","KIAA0184"],"approved_symbol":"DIP2A","ensembl_gene_id":"ENSG00000160305","hgnc_id":"HGNC:17217","ncbi_gene_id":23181,"previous_symbols":["C21orf106"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIP2A","release_manifest":"api/v1.1/release_manifest.json"}},"DIP2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIP2B","identifiers":{"aliases":["KIAA1463","FLJ34278"],"approved_symbol":"DIP2B","ensembl_gene_id":"ENSG00000066084","hgnc_id":"HGNC:29284","ncbi_gene_id":57609,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIP2B","release_manifest":"api/v1.1/release_manifest.json"}},"DIP2C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIP2C","identifiers":{"aliases":[],"approved_symbol":"DIP2C","ensembl_gene_id":"ENSG00000151240","hgnc_id":"HGNC:29150","ncbi_gene_id":22982,"previous_symbols":["KIAA0934"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIP2C","release_manifest":"api/v1.1/release_manifest.json"}},"DIPK1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIPK1A","identifiers":{"aliases":["FLJ23493"],"approved_symbol":"DIPK1A","ensembl_gene_id":"ENSG00000154511","hgnc_id":"HGNC:32213","ncbi_gene_id":388650,"previous_symbols":["FAM69A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIPK1A","release_manifest":"api/v1.1/release_manifest.json"}},"DIPK1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIPK1B","identifiers":{"aliases":["MGC20262","C9orf136"],"approved_symbol":"DIPK1B","ensembl_gene_id":"ENSG00000165716","hgnc_id":"HGNC:28290","ncbi_gene_id":138311,"previous_symbols":["FAM69B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIPK1B","release_manifest":"api/v1.1/release_manifest.json"}},"DIPK1C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIPK1C","identifiers":{"aliases":[],"approved_symbol":"DIPK1C","ensembl_gene_id":"ENSG00000187773","hgnc_id":"HGNC:31729","ncbi_gene_id":125704,"previous_symbols":["C18orf51","FAM69C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIPK1C","release_manifest":"api/v1.1/release_manifest.json"}},"DIPK2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIPK2A","identifiers":{"aliases":["MGC33365","DIA1","HASF"],"approved_symbol":"DIPK2A","ensembl_gene_id":"ENSG00000181744","hgnc_id":"HGNC:28490","ncbi_gene_id":205428,"previous_symbols":["C3orf58"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIPK2A","release_manifest":"api/v1.1/release_manifest.json"}},"DIPK2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIPK2B","identifiers":{"aliases":["FLJ14103","DIA1R"],"approved_symbol":"DIPK2B","ensembl_gene_id":"ENSG00000147113","hgnc_id":"HGNC:25866","ncbi_gene_id":79742,"previous_symbols":["CXorf36"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIPK2B","release_manifest":"api/v1.1/release_manifest.json"}},"DIRAS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIRAS1","identifiers":{"aliases":["Di-Ras1","GBTS1","RIG"],"approved_symbol":"DIRAS1","ensembl_gene_id":"ENSG00000176490","hgnc_id":"HGNC:19127","ncbi_gene_id":148252,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DIRAS1","release_manifest":"api/v1.1/release_manifest.json"}},"DIRAS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIRAS2","identifiers":{"aliases":["Di-Ras2","DKFZp761C07121"],"approved_symbol":"DIRAS2","ensembl_gene_id":"ENSG00000165023","hgnc_id":"HGNC:19323","ncbi_gene_id":54769,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DIRAS2","release_manifest":"api/v1.1/release_manifest.json"}},"DIRAS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIRAS3","identifiers":{"aliases":["NOEY2"],"approved_symbol":"DIRAS3","ensembl_gene_id":"ENSG00000162595","hgnc_id":"HGNC:687","ncbi_gene_id":9077,"previous_symbols":["ARHI"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIRAS3","release_manifest":"api/v1.1/release_manifest.json"}},"DIRC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIRC3","identifiers":{"aliases":["FLJ14199"],"approved_symbol":"DIRC3","ensembl_gene_id":"ENSG00000231672","hgnc_id":"HGNC:17805","ncbi_gene_id":729582,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIRC3","release_manifest":"api/v1.1/release_manifest.json"}},"DIRC3-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIRC3-AS1","identifiers":{"approved_symbol":"DIRC3-AS1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DIRC3-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DIS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIS3","identifiers":{"aliases":["dis3p","RRP44","EXOSC11"],"approved_symbol":"DIS3","ensembl_gene_id":"ENSG00000083520","hgnc_id":"HGNC:20604","ncbi_gene_id":22894,"previous_symbols":["KIAA1008"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIS3","release_manifest":"api/v1.1/release_manifest.json"}},"DIS3L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIS3L","identifiers":{"aliases":["MGC4562","FLJ38088","KIAA1955","DIS3L1"],"approved_symbol":"DIS3L","ensembl_gene_id":"ENSG00000166938","hgnc_id":"HGNC:28698","ncbi_gene_id":115752,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIS3L","release_manifest":"api/v1.1/release_manifest.json"}},"DIS3L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIS3L2","identifiers":{"aliases":["FLJ36974","MGC42174"],"approved_symbol":"DIS3L2","ensembl_gene_id":"ENSG00000144535","hgnc_id":"HGNC:28648","ncbi_gene_id":129563,"previous_symbols":["FAM6A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIS3L2","release_manifest":"api/v1.1/release_manifest.json"}},"DISC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DISC1","identifiers":{"aliases":[],"approved_symbol":"DISC1","ensembl_gene_id":"ENSG00000162946","hgnc_id":"HGNC:2888","ncbi_gene_id":27185,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DISC1","release_manifest":"api/v1.1/release_manifest.json"}},"DISC1FP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DISC1FP1","identifiers":{"aliases":["Boymaw"],"approved_symbol":"DISC1FP1","ensembl_gene_id":"ENSG00000261645","hgnc_id":"HGNC:33625","ncbi_gene_id":101929222,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DISC1FP1","release_manifest":"api/v1.1/release_manifest.json"}},"DISP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DISP1","identifiers":{"aliases":["DISPA","MGC13130","DKFZP434I0428","MGC16796"],"approved_symbol":"DISP1","ensembl_gene_id":"ENSG00000154309","hgnc_id":"HGNC:19711","ncbi_gene_id":84976,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DISP1","release_manifest":"api/v1.1/release_manifest.json"}},"DISP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DISP3","identifiers":{"aliases":["KIAA1337"],"approved_symbol":"DISP3","ensembl_gene_id":"ENSG00000204624","hgnc_id":"HGNC:29251","ncbi_gene_id":57540,"previous_symbols":["PTCHD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DISP3","release_manifest":"api/v1.1/release_manifest.json"}},"DIXDC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DIXDC1","identifiers":{"aliases":["KIAA1735","Dixin"],"approved_symbol":"DIXDC1","ensembl_gene_id":"ENSG00000150764","hgnc_id":"HGNC:23695","ncbi_gene_id":85458,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DIXDC1","release_manifest":"api/v1.1/release_manifest.json"}},"DKC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DKC1","identifiers":{"aliases":["XAP101","dyskerin","NAP57","NOLA4","Cbf5"],"approved_symbol":"DKC1","ensembl_gene_id":"ENSG00000130826","hgnc_id":"HGNC:2890","ncbi_gene_id":1736,"previous_symbols":["DKC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DKC1","release_manifest":"api/v1.1/release_manifest.json"}},"DKK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DKK1","identifiers":{"aliases":["SK","DKK-1"],"approved_symbol":"DKK1","ensembl_gene_id":"ENSG00000107984","hgnc_id":"HGNC:2891","ncbi_gene_id":22943,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DKK1","release_manifest":"api/v1.1/release_manifest.json"}},"DKK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DKK2","identifiers":{"aliases":[],"approved_symbol":"DKK2","ensembl_gene_id":"ENSG00000155011","hgnc_id":"HGNC:2892","ncbi_gene_id":27123,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DKK2","release_manifest":"api/v1.1/release_manifest.json"}},"DKK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DKK3","identifiers":{"aliases":["REIC","RIG","CRRL"],"approved_symbol":"DKK3","ensembl_gene_id":"ENSG00000050165","hgnc_id":"HGNC:2893","ncbi_gene_id":27122,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DKK3","detailed_audit_record":"gene/DKK3/audit","legacy_api_record":"api/v1/genes/DKK3.json","release_manifest":"api/v1.1/release_manifest.json"}},"DKK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DKK4","identifiers":{"aliases":[],"approved_symbol":"DKK4","ensembl_gene_id":"ENSG00000104371","hgnc_id":"HGNC:2894","ncbi_gene_id":27121,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DKK4","release_manifest":"api/v1.1/release_manifest.json"}},"DKKL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DKKL1","identifiers":{"aliases":["SGY-1","CT34"],"approved_symbol":"DKKL1","ensembl_gene_id":"ENSG00000104901","hgnc_id":"HGNC:16528","ncbi_gene_id":27120,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DKKL1","release_manifest":"api/v1.1/release_manifest.json"}},"DLAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLAT","identifiers":{"aliases":["PDC-E2","E2"],"approved_symbol":"DLAT","ensembl_gene_id":"ENSG00000150768","hgnc_id":"HGNC:2896","ncbi_gene_id":1737,"previous_symbols":["DLTA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLAT","release_manifest":"api/v1.1/release_manifest.json"}},"DLC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLC1","identifiers":{"aliases":["HP","ARHGAP7","STARD12","DLC-1","p122-RhoGAP"],"approved_symbol":"DLC1","ensembl_gene_id":"ENSG00000164741","hgnc_id":"HGNC:2897","ncbi_gene_id":10395,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLC1","release_manifest":"api/v1.1/release_manifest.json"}},"DLD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLD","identifiers":{"aliases":["DLDH","E3","OGDC-E3"],"approved_symbol":"DLD","ensembl_gene_id":"ENSG00000091140","hgnc_id":"HGNC:2898","ncbi_gene_id":1738,"previous_symbols":["LAD","GCSL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.13499,"fdr":0.554639,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLD","release_manifest":"api/v1.1/release_manifest.json"}},"DLEC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLEC1","identifiers":{"aliases":["DLC1","CFAP81","FAP81"],"approved_symbol":"DLEC1","ensembl_gene_id":"ENSG00000008226","hgnc_id":"HGNC:2899","ncbi_gene_id":9940,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLEC1","release_manifest":"api/v1.1/release_manifest.json"}},"DLEU1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLEU1","identifiers":{"aliases":["LEU1","XTP6","NCRNA00021","LINC00021","BCMS1"],"approved_symbol":"DLEU1","ensembl_gene_id":"ENSG00000176124","hgnc_id":"HGNC:13747","ncbi_gene_id":10301,"previous_symbols":["DLB1","BCMS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLEU1","release_manifest":"api/v1.1/release_manifest.json"}},"DLEU2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLEU2","identifiers":{"aliases":["LEU2","TRIM13OS","NCRNA00022","LINC00022","MIR15AHG"],"approved_symbol":"DLEU2","ensembl_gene_id":"ENSG00000231607","hgnc_id":"HGNC:13748","ncbi_gene_id":8847,"previous_symbols":["DLB2","BCMSUN","RFP2OS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLEU2","release_manifest":"api/v1.1/release_manifest.json"}},"DLEU2L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLEU2L","identifiers":{"aliases":[],"approved_symbol":"DLEU2L","ensembl_gene_id":"ENSG00000116652","hgnc_id":"HGNC:13225","ncbi_gene_id":79469,"previous_symbols":["BCMSUNL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLEU2L","release_manifest":"api/v1.1/release_manifest.json"}},"DLEU7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLEU7","identifiers":{"aliases":["FLJ44882"],"approved_symbol":"DLEU7","ensembl_gene_id":"ENSG00000186047","hgnc_id":"HGNC:17567","ncbi_gene_id":220107,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLEU7","release_manifest":"api/v1.1/release_manifest.json"}},"DLG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLG1","identifiers":{"aliases":["SAP97","SAP-97","hdlg","DLGH1","dJ1061C18.1.1"],"approved_symbol":"DLG1","ensembl_gene_id":"ENSG00000075711","hgnc_id":"HGNC:2900","ncbi_gene_id":1739,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLG1","release_manifest":"api/v1.1/release_manifest.json"}},"DLG2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLG2","identifiers":{"aliases":["PSD-93","PSD93","chapsyn-110","PPP1R58"],"approved_symbol":"DLG2","ensembl_gene_id":"ENSG00000150672","hgnc_id":"HGNC:2901","ncbi_gene_id":1740,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLG2","release_manifest":"api/v1.1/release_manifest.json"}},"DLG3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLG3","identifiers":{"aliases":["NE-Dlg","SAP102","SAP-102","NEDLG","KIAA1232","MRX90","PPP1R82"],"approved_symbol":"DLG3","ensembl_gene_id":"ENSG00000082458","hgnc_id":"HGNC:2902","ncbi_gene_id":1741,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLG3","release_manifest":"api/v1.1/release_manifest.json"}},"DLG4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLG4","identifiers":{"aliases":["PSD-95","PSD95","SAP90","SAP-90"],"approved_symbol":"DLG4","ensembl_gene_id":"ENSG00000132535","hgnc_id":"HGNC:2903","ncbi_gene_id":1742,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLG4","release_manifest":"api/v1.1/release_manifest.json"}},"DLG5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLG5","identifiers":{"aliases":["P-dlg","KIAA0583"],"approved_symbol":"DLG5","ensembl_gene_id":"ENSG00000151208","hgnc_id":"HGNC:2904","ncbi_gene_id":9231,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLG5","release_manifest":"api/v1.1/release_manifest.json"}},"DLG5-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLG5-AS1","identifiers":{"aliases":[],"approved_symbol":"DLG5-AS1","ensembl_gene_id":"ENSG00000233871","hgnc_id":"HGNC:45109","ncbi_gene_id":100128292,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLG5-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP1","identifiers":{"aliases":["GKAP","SAPAP1","DAP-1"],"approved_symbol":"DLGAP1","ensembl_gene_id":"ENSG00000170579","hgnc_id":"HGNC:2905","ncbi_gene_id":9229,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP1","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP1-AS1","identifiers":{"aliases":["HsT914","FLJ35776"],"approved_symbol":"DLGAP1-AS1","ensembl_gene_id":"ENSG00000177337","hgnc_id":"HGNC:31676","ncbi_gene_id":649446,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP1-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP1-AS2","identifiers":{"aliases":["MGC11082"],"approved_symbol":"DLGAP1-AS2","ensembl_gene_id":"ENSG00000262001","hgnc_id":"HGNC:28146","ncbi_gene_id":84777,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP1-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP1-AS4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP1-AS4","identifiers":{"aliases":[],"approved_symbol":"DLGAP1-AS4","ensembl_gene_id":"ENSG00000263878","hgnc_id":"HGNC:44333","ncbi_gene_id":101410534,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DLGAP1-AS4","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP1-AS5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP1-AS5","identifiers":{"aliases":[],"approved_symbol":"DLGAP1-AS5","ensembl_gene_id":"ENSG00000261520","hgnc_id":"HGNC:27586","ncbi_gene_id":284215,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DLGAP1-AS5","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP2","identifiers":{"aliases":["DAP-2"],"approved_symbol":"DLGAP2","ensembl_gene_id":"ENSG00000198010","hgnc_id":"HGNC:2906","ncbi_gene_id":9228,"previous_symbols":["ERICH1-AS1","C8orf68"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP2","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP3","identifiers":{"aliases":["SAPAP3","DAP3"],"approved_symbol":"DLGAP3","ensembl_gene_id":"ENSG00000116544","hgnc_id":"HGNC:30368","ncbi_gene_id":58512,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP3","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP4","identifiers":{"aliases":["DAP4","KIAA0964","SAPAP4"],"approved_symbol":"DLGAP4","ensembl_gene_id":"ENSG00000080845","hgnc_id":"HGNC:24476","ncbi_gene_id":22839,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP4","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP4-AS1","identifiers":{"aliases":["CCAT7"],"approved_symbol":"DLGAP4-AS1","ensembl_gene_id":"ENSG00000232907","hgnc_id":"HGNC:51223","ncbi_gene_id":101926987,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DLGAP5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLGAP5","identifiers":{"aliases":["KIAA0008","DLG1","HURP"],"approved_symbol":"DLGAP5","ensembl_gene_id":"ENSG00000126787","hgnc_id":"HGNC:16864","ncbi_gene_id":9787,"previous_symbols":["DLG7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLGAP5","release_manifest":"api/v1.1/release_manifest.json"}},"DLK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLK1","identifiers":{"aliases":["FA1","pG2","Pref-1","ZOG","Delta1"],"approved_symbol":"DLK1","ensembl_gene_id":"ENSG00000185559","hgnc_id":"HGNC:2907","ncbi_gene_id":8788,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLK1","detailed_audit_record":"gene/DLK1/audit","legacy_api_record":"api/v1/genes/DLK1.json","release_manifest":"api/v1.1/release_manifest.json"}},"DLK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLK2","identifiers":{"aliases":["MGC2487"],"approved_symbol":"DLK2","ensembl_gene_id":"ENSG00000171462","hgnc_id":"HGNC:21113","ncbi_gene_id":65989,"previous_symbols":["EGFL9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DLK2","release_manifest":"api/v1.1/release_manifest.json"}},"DLL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLL1","identifiers":{"aliases":[],"approved_symbol":"DLL1","ensembl_gene_id":"ENSG00000198719","hgnc_id":"HGNC:2908","ncbi_gene_id":28514,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLL1","release_manifest":"api/v1.1/release_manifest.json"}},"DLL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLL3","identifiers":{"aliases":["SCDO1"],"approved_symbol":"DLL3","ensembl_gene_id":"ENSG00000090932","hgnc_id":"HGNC:2909","ncbi_gene_id":10683,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLL3","release_manifest":"api/v1.1/release_manifest.json"}},"DLL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLL4","identifiers":{"aliases":[],"approved_symbol":"DLL4","ensembl_gene_id":"ENSG00000128917","hgnc_id":"HGNC:2910","ncbi_gene_id":54567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLL4","release_manifest":"api/v1.1/release_manifest.json"}},"DLST":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLST","identifiers":{"aliases":["OGDC-E2","KGD2"],"approved_symbol":"DLST","ensembl_gene_id":"ENSG00000119689","hgnc_id":"HGNC:2911","ncbi_gene_id":1743,"previous_symbols":["DLTS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLST","release_manifest":"api/v1.1/release_manifest.json"}},"DLX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLX2","identifiers":{"aliases":["TES-1"],"approved_symbol":"DLX2","ensembl_gene_id":"ENSG00000115844","hgnc_id":"HGNC:2915","ncbi_gene_id":1746,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLX2","release_manifest":"api/v1.1/release_manifest.json"}},"DLX3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLX3","identifiers":{"aliases":[],"approved_symbol":"DLX3","ensembl_gene_id":"ENSG00000064195","hgnc_id":"HGNC:2916","ncbi_gene_id":1747,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DLX3","release_manifest":"api/v1.1/release_manifest.json"}},"DLX5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DLX5","identifiers":{"aliases":[],"approved_symbol":"DLX5","ensembl_gene_id":"ENSG00000105880","hgnc_id":"HGNC:2918","ncbi_gene_id":1749,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DLX5","release_manifest":"api/v1.1/release_manifest.json"}},"DMAC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMAC1","identifiers":{"aliases":["MGC4730"],"approved_symbol":"DMAC1","ensembl_gene_id":"ENSG00000137038","hgnc_id":"HGNC:30536","ncbi_gene_id":90871,"previous_symbols":["C9orf123","TMEM261"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMAC1","release_manifest":"api/v1.1/release_manifest.json"}},"DMAC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMAC2","identifiers":{"aliases":["FLJ10241"],"approved_symbol":"DMAC2","ensembl_gene_id":"ENSG00000105341","hgnc_id":"HGNC:25496","ncbi_gene_id":55101,"previous_symbols":["ATP5SL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMAC2","release_manifest":"api/v1.1/release_manifest.json"}},"DMAC2L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMAC2L","identifiers":{"aliases":["HSU79253","ATPW"],"approved_symbol":"DMAC2L","ensembl_gene_id":"ENSG00000125375","hgnc_id":"HGNC:18799","ncbi_gene_id":27109,"previous_symbols":["ATP5S"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMAC2L","release_manifest":"api/v1.1/release_manifest.json"}},"DMAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMAP1","identifiers":{"aliases":["DNMAP1","FLJ11543","KIAA1425","DNMTAP1","EAF2","MEAF2","SWC4"],"approved_symbol":"DMAP1","ensembl_gene_id":"ENSG00000178028","hgnc_id":"HGNC:18291","ncbi_gene_id":55929,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMAP1","release_manifest":"api/v1.1/release_manifest.json"}},"DMBT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMBT1","identifiers":{"aliases":["GP340","SALSA","Gp-340"],"approved_symbol":"DMBT1","ensembl_gene_id":"ENSG00000187908","hgnc_id":"HGNC:2926","ncbi_gene_id":1755,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DMBT1","release_manifest":"api/v1.1/release_manifest.json"}},"DMC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMC1","identifiers":{"aliases":["LIM15"],"approved_symbol":"DMC1","ensembl_gene_id":"ENSG00000100206","hgnc_id":"HGNC:2927","ncbi_gene_id":11144,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMC1","release_manifest":"api/v1.1/release_manifest.json"}},"DMD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMD","identifiers":{"aliases":["BMD","DXS142","DXS164","DXS206","DXS230","DXS239","DXS268","DXS269","DXS270","DXS272"],"approved_symbol":"DMD","ensembl_gene_id":"ENSG00000198947","hgnc_id":"HGNC:2928","ncbi_gene_id":1756,"previous_symbols":["MRX85"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/DMD","release_manifest":"api/v1.1/release_manifest.json"}},"DMGDH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMGDH","identifiers":{"aliases":["ME2GLYDH"],"approved_symbol":"DMGDH","ensembl_gene_id":"ENSG00000132837","hgnc_id":"HGNC:24475","ncbi_gene_id":29958,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMGDH","release_manifest":"api/v1.1/release_manifest.json"}},"DMKN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMKN","identifiers":{"aliases":["ZD52F10"],"approved_symbol":"DMKN","ensembl_gene_id":"ENSG00000161249","hgnc_id":"HGNC:25063","ncbi_gene_id":93099,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMKN","release_manifest":"api/v1.1/release_manifest.json"}},"DMP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMP1","identifiers":{"aliases":[],"approved_symbol":"DMP1","ensembl_gene_id":"ENSG00000152592","hgnc_id":"HGNC:2932","ncbi_gene_id":1758,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DMP1","release_manifest":"api/v1.1/release_manifest.json"}},"DMPK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMPK","identifiers":{"aliases":["DMK","DM1PK","MDPK","MT-PK"],"approved_symbol":"DMPK","ensembl_gene_id":"ENSG00000104936","hgnc_id":"HGNC:2933","ncbi_gene_id":1760,"previous_symbols":["DM1","DM"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMPK","release_manifest":"api/v1.1/release_manifest.json"}},"DMRT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMRT1","identifiers":{"aliases":["DMT1","CT154"],"approved_symbol":"DMRT1","ensembl_gene_id":"ENSG00000137090","hgnc_id":"HGNC:2934","ncbi_gene_id":1761,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DMRT1","release_manifest":"api/v1.1/release_manifest.json"}},"DMRT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMRT2","identifiers":{"aliases":[],"approved_symbol":"DMRT2","ensembl_gene_id":"ENSG00000173253","hgnc_id":"HGNC:2935","ncbi_gene_id":10655,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMRT2","release_manifest":"api/v1.1/release_manifest.json"}},"DMRT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMRT3","identifiers":{"aliases":[],"approved_symbol":"DMRT3","ensembl_gene_id":"ENSG00000064218","hgnc_id":"HGNC:13909","ncbi_gene_id":58524,"previous_symbols":["DMRTA3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMRT3","release_manifest":"api/v1.1/release_manifest.json"}},"DMRTA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMRTA1","identifiers":{"aliases":["DMRT4"],"approved_symbol":"DMRTA1","ensembl_gene_id":"ENSG00000176399","hgnc_id":"HGNC:13826","ncbi_gene_id":63951,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DMRTA1","release_manifest":"api/v1.1/release_manifest.json"}},"DMTF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMTF1","identifiers":{"aliases":["DMP1","DMTF","hDMP1","MRUL"],"approved_symbol":"DMTF1","ensembl_gene_id":"ENSG00000135164","hgnc_id":"HGNC:14603","ncbi_gene_id":9988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMTF1","release_manifest":"api/v1.1/release_manifest.json"}},"DMTN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMTN","identifiers":{"aliases":["DMT"],"approved_symbol":"DMTN","ensembl_gene_id":"ENSG00000158856","hgnc_id":"HGNC:3382","ncbi_gene_id":2039,"previous_symbols":["EPB49"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMTN","release_manifest":"api/v1.1/release_manifest.json"}},"DMWD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMWD","identifiers":{"aliases":["DMR-N9","gene59","D19S593E"],"approved_symbol":"DMWD","ensembl_gene_id":"ENSG00000185800","hgnc_id":"HGNC:2936","ncbi_gene_id":1762,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMWD","release_manifest":"api/v1.1/release_manifest.json"}},"DMXL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMXL1","identifiers":{"aliases":[],"approved_symbol":"DMXL1","ensembl_gene_id":"ENSG00000172869","hgnc_id":"HGNC:2937","ncbi_gene_id":1657,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DMXL1","release_manifest":"api/v1.1/release_manifest.json"}},"DMXL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DMXL2","identifiers":{"aliases":["RC3","KIAA0856","DFNA71"],"approved_symbol":"DMXL2","ensembl_gene_id":"ENSG00000104093","hgnc_id":"HGNC:2938","ncbi_gene_id":23312,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DMXL2","release_manifest":"api/v1.1/release_manifest.json"}},"DNA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNA2","identifiers":{"aliases":["KIAA0083"],"approved_symbol":"DNA2","ensembl_gene_id":"ENSG00000138346","hgnc_id":"HGNC:2939","ncbi_gene_id":1763,"previous_symbols":["DNA2L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNA2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAAF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAAF1","identifiers":{"aliases":["FLJ25330","ODA7","CILD13","swt","DAU1"],"approved_symbol":"DNAAF1","ensembl_gene_id":"ENSG00000154099","hgnc_id":"HGNC:30539","ncbi_gene_id":123872,"previous_symbols":["LRRC50"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAAF1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAAF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAAF2","identifiers":{"aliases":["FLJ10563","KTU","pf13","CILD10"],"approved_symbol":"DNAAF2","ensembl_gene_id":"ENSG00000165506","hgnc_id":"HGNC:20188","ncbi_gene_id":55172,"previous_symbols":["C14orf104"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAAF2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAAF3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAAF3","identifiers":{"aliases":["FLJ40069","FLJ36139","pf22","PCD"],"approved_symbol":"DNAAF3","ensembl_gene_id":"ENSG00000167646","hgnc_id":"HGNC:30492","ncbi_gene_id":352909,"previous_symbols":["C19orf51","CILD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L2_observed_same_context_perturbation","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":115},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"verify_expression","current_display_label":"Verify expression","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":10,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-06","label":"Expression feasibility is not verified in the intended model"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-03 DMD-relevant functional validation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":0.0755557,"depmap_median_gene_effect":0.0598274924538474,"moderate_dependency_flag":false,"observed_counteralignment":0.0344381820755609},"summary":"Priority B · multisource follow-up; observed DMD-prior counteralignment 0.0344; observed cells 115; integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DNAAF3","detailed_audit_record":"gene/DNAAF3/audit","legacy_api_record":"api/v1/genes/DNAAF3.json","release_manifest":"api/v1.1/release_manifest.json"}},"DNAAF4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAAF4","identifiers":{"aliases":["EKN1","FLJ37882","CILD25","pf23"],"approved_symbol":"DNAAF4","ensembl_gene_id":"ENSG00000256061","hgnc_id":"HGNC:21493","ncbi_gene_id":161582,"previous_symbols":["DYX1C1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAAF4","release_manifest":"api/v1.1/release_manifest.json"}},"DNAAF5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAAF5","identifiers":{"aliases":["FLJ20397","FLJ31671","FLJ39381","FLJ25564","CILD18"],"approved_symbol":"DNAAF5","ensembl_gene_id":"ENSG00000164818","hgnc_id":"HGNC:26013","ncbi_gene_id":54919,"previous_symbols":["HEATR2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAAF5","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH1","identifiers":{"aliases":["XLHSRF-1","DNAHC1","HDHC7","HL-11","HL11"],"approved_symbol":"DNAH1","ensembl_gene_id":"ENSG00000114841","hgnc_id":"HGNC:2940","ncbi_gene_id":25981,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH10","identifiers":{"aliases":["FLJ43808"],"approved_symbol":"DNAH10","ensembl_gene_id":"ENSG00000197653","hgnc_id":"HGNC:2941","ncbi_gene_id":196385,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAH10","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH10OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH10OS","identifiers":{"aliases":["FLJ45278"],"approved_symbol":"DNAH10OS","ensembl_gene_id":"ENSG00000250091","hgnc_id":"HGNC:37121","ncbi_gene_id":642797,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DNAH10OS","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH11","identifiers":{"aliases":["Dnahc11","DPL11","CILD7","DNAHC11","DNAHBL","DNHBL"],"approved_symbol":"DNAH11","ensembl_gene_id":"ENSG00000105877","hgnc_id":"HGNC:2942","ncbi_gene_id":8701,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH11","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH12","identifiers":{"aliases":["DLP12","Dnahc3","HL-19","hdhc3","DHC3","FLJ40427","FLJ44290"],"approved_symbol":"DNAH12","ensembl_gene_id":"ENSG00000174844","hgnc_id":"HGNC:2943","ncbi_gene_id":201625,"previous_symbols":["DNHD2","DNAH12L","DNAH7L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH12","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH14","identifiers":{"aliases":["Dnahc14","HL-18","HL18","DKFZp781B1548","MGC27277"],"approved_symbol":"DNAH14","ensembl_gene_id":"ENSG00000185842","hgnc_id":"HGNC:2945","ncbi_gene_id":127602,"previous_symbols":["C1orf67"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH14","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH17","identifiers":{"aliases":["DNEL2","FLJ40457"],"approved_symbol":"DNAH17","ensembl_gene_id":"ENSG00000187775","hgnc_id":"HGNC:2946","ncbi_gene_id":8632,"previous_symbols":["DNAHL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH17","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH2","identifiers":{"aliases":["KIAA1503","FLJ46675"],"approved_symbol":"DNAH2","ensembl_gene_id":"ENSG00000183914","hgnc_id":"HGNC:2948","ncbi_gene_id":146754,"previous_symbols":["DNHD3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH3","identifiers":{"aliases":["Dnahc3b","DLP3","Hsadhc3","DKFZp434N074"],"approved_symbol":"DNAH3","ensembl_gene_id":"ENSG00000158486","hgnc_id":"HGNC:2949","ncbi_gene_id":55567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH3","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH5","identifiers":{"aliases":["Dnahc5","HL1","PCD","CILD3","KTGNR"],"approved_symbol":"DNAH5","ensembl_gene_id":"ENSG00000039139","hgnc_id":"HGNC:2950","ncbi_gene_id":1767,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH5","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH6","identifiers":{"aliases":["Dnahc6","HL-2","FLJ37357"],"approved_symbol":"DNAH6","ensembl_gene_id":"ENSG00000115423","hgnc_id":"HGNC:2951","ncbi_gene_id":1768,"previous_symbols":["DNHL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH6","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH7","identifiers":{"aliases":["KIAA0944"],"approved_symbol":"DNAH7","ensembl_gene_id":"ENSG00000118997","hgnc_id":"HGNC:18661","ncbi_gene_id":56171,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH7","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH8","identifiers":{"aliases":["hdhc9"],"approved_symbol":"DNAH8","ensembl_gene_id":"ENSG00000124721","hgnc_id":"HGNC:2952","ncbi_gene_id":1769,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DNAH8","release_manifest":"api/v1.1/release_manifest.json"}},"DNAH9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAH9","identifiers":{"aliases":["Dnahc9","KIAA0357","HL20","HL-20","DNAL1","DYH9"],"approved_symbol":"DNAH9","ensembl_gene_id":"ENSG00000007174","hgnc_id":"HGNC:2953","ncbi_gene_id":1770,"previous_symbols":["DNAH17L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAH9","release_manifest":"api/v1.1/release_manifest.json"}},"DNAI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAI1","identifiers":{"aliases":["DIC1","PCD","CILD1","oda6"],"approved_symbol":"DNAI1","ensembl_gene_id":"ENSG00000122735","hgnc_id":"HGNC:2954","ncbi_gene_id":27019,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DNAI1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAI2","identifiers":{"aliases":["CILD9","DIC2","oda6"],"approved_symbol":"DNAI2","ensembl_gene_id":"ENSG00000171595","hgnc_id":"HGNC:18744","ncbi_gene_id":64446,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAI2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJA1","identifiers":{"aliases":["HSPF4","hdj-2","dj-2","NEDD7"],"approved_symbol":"DNAJA1","ensembl_gene_id":"ENSG00000086061","hgnc_id":"HGNC:5229","ncbi_gene_id":3301,"previous_symbols":["HSJ2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJA1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJA2","identifiers":{"aliases":["HIRIP4","DNAJ","CPR3","DNJ3"],"approved_symbol":"DNAJA2","ensembl_gene_id":"ENSG00000069345","hgnc_id":"HGNC:14884","ncbi_gene_id":10294,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJA2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJA3","identifiers":{"aliases":["hTid-1","Tid1-S","Tid1-L"],"approved_symbol":"DNAJA3","ensembl_gene_id":"ENSG00000103423","hgnc_id":"HGNC:11808","ncbi_gene_id":9093,"previous_symbols":["TID1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJA3","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJA4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJA4","identifiers":{"aliases":["PRO1472"],"approved_symbol":"DNAJA4","ensembl_gene_id":"ENSG00000140403","hgnc_id":"HGNC:14885","ncbi_gene_id":55466,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJA4","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB1","identifiers":{"aliases":["Hsp40","Sis1","RSPH16B"],"approved_symbol":"DNAJB1","ensembl_gene_id":"ENSG00000132002","hgnc_id":"HGNC:5270","ncbi_gene_id":3337,"previous_symbols":["HSPF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB11","identifiers":{"aliases":["EDJ","HEDJ","ERdj3"],"approved_symbol":"DNAJB11","ensembl_gene_id":"ENSG00000090520","hgnc_id":"HGNC:14889","ncbi_gene_id":51726,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAJB11","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB12","identifiers":{"aliases":["DJ10","FLJ20027"],"approved_symbol":"DNAJB12","ensembl_gene_id":"ENSG00000148719","hgnc_id":"HGNC:14891","ncbi_gene_id":54788,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB12","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB13","identifiers":{"aliases":["TSARG6","RSPH16A"],"approved_symbol":"DNAJB13","ensembl_gene_id":"ENSG00000187726","hgnc_id":"HGNC:30718","ncbi_gene_id":374407,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB13","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB14","identifiers":{"aliases":["FLJ14281"],"approved_symbol":"DNAJB14","ensembl_gene_id":"ENSG00000164031","hgnc_id":"HGNC:25881","ncbi_gene_id":79982,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB14","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB2","identifiers":{"aliases":["HSPF3","CMT2T"],"approved_symbol":"DNAJB2","ensembl_gene_id":"ENSG00000135924","hgnc_id":"HGNC:5228","ncbi_gene_id":3300,"previous_symbols":["HSJ1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB4","identifiers":{"aliases":["HLJ1"],"approved_symbol":"DNAJB4","ensembl_gene_id":"ENSG00000162616","hgnc_id":"HGNC:14886","ncbi_gene_id":11080,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB4","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB5","identifiers":{"aliases":["Hsc40"],"approved_symbol":"DNAJB5","ensembl_gene_id":"ENSG00000137094","hgnc_id":"HGNC:14887","ncbi_gene_id":25822,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB5","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB5-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB5-DT","identifiers":{"aliases":[],"approved_symbol":"DNAJB5-DT","ensembl_gene_id":"ENSG00000281491","hgnc_id":"HGNC:49846","ncbi_gene_id":101926900,"previous_symbols":["DNAJB5-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB5-DT","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB6","identifiers":{"aliases":["MRJ"],"approved_symbol":"DNAJB6","ensembl_gene_id":"ENSG00000105993","hgnc_id":"HGNC:14888","ncbi_gene_id":10049,"previous_symbols":["LGMD1D"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/DNAJB6","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJB9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJB9","identifiers":{"aliases":[],"approved_symbol":"DNAJB9","ensembl_gene_id":"ENSG00000128590","hgnc_id":"HGNC:6968","ncbi_gene_id":4189,"previous_symbols":["MDG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJB9","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC1","identifiers":{"aliases":["DNAJL1","ERdj1","MTJ1"],"approved_symbol":"DNAJC1","ensembl_gene_id":"ENSG00000136770","hgnc_id":"HGNC:20090","ncbi_gene_id":64215,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC10","identifiers":{"aliases":["ERdj5","PDIA19"],"approved_symbol":"DNAJC10","ensembl_gene_id":"ENSG00000077232","hgnc_id":"HGNC:24637","ncbi_gene_id":54431,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC10","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC11","identifiers":{"aliases":["FLJ10737"],"approved_symbol":"DNAJC11","ensembl_gene_id":"ENSG00000007923","hgnc_id":"HGNC:25570","ncbi_gene_id":55735,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC11","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC12","identifiers":{"aliases":["JDP1"],"approved_symbol":"DNAJC12","ensembl_gene_id":"ENSG00000108176","hgnc_id":"HGNC:28908","ncbi_gene_id":56521,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC12","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC13","identifiers":{"aliases":["RME8","KIAA0678"],"approved_symbol":"DNAJC13","ensembl_gene_id":"ENSG00000138246","hgnc_id":"HGNC:30343","ncbi_gene_id":23317,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC13","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC14","identifiers":{"aliases":["DNAJ","DRIP78","HDJ3","LIP6","FLJ32792"],"approved_symbol":"DNAJC14","ensembl_gene_id":"ENSG00000135392","hgnc_id":"HGNC:24581","ncbi_gene_id":85406,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC14","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC15","identifiers":{"aliases":["MCJ"],"approved_symbol":"DNAJC15","ensembl_gene_id":"ENSG00000120675","hgnc_id":"HGNC:20325","ncbi_gene_id":29103,"previous_symbols":["DNAJD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC15","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC16","identifiers":{"aliases":["KIAA0962"],"approved_symbol":"DNAJC16","ensembl_gene_id":"ENSG00000116138","hgnc_id":"HGNC:29157","ncbi_gene_id":23341,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC16","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC17","identifiers":{"aliases":["FLJ10634"],"approved_symbol":"DNAJC17","ensembl_gene_id":"ENSG00000104129","hgnc_id":"HGNC:25556","ncbi_gene_id":55192,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC17","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC18","identifiers":{"aliases":["MGC29463"],"approved_symbol":"DNAJC18","ensembl_gene_id":"ENSG00000170464","hgnc_id":"HGNC:28429","ncbi_gene_id":202052,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC18","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC19","identifiers":{"aliases":["TIMM14","Tim14","Pam18"],"approved_symbol":"DNAJC19","ensembl_gene_id":"ENSG00000205981","hgnc_id":"HGNC:30528","ncbi_gene_id":131118,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.00092001,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC19","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC2","identifiers":{"aliases":["MPP11","MPHOSPH11","ZUO1","zuotin"],"approved_symbol":"DNAJC2","ensembl_gene_id":"ENSG00000105821","hgnc_id":"HGNC:13192","ncbi_gene_id":27000,"previous_symbols":["ZRF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAJC2","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC21","identifiers":{"aliases":["GS3","DNAJA5","JJJ1"],"approved_symbol":"DNAJC21","ensembl_gene_id":"ENSG00000168724","hgnc_id":"HGNC:27030","ncbi_gene_id":134218,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC21","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC22","identifiers":{"aliases":["wus","FLJ13236"],"approved_symbol":"DNAJC22","ensembl_gene_id":"ENSG00000178401","hgnc_id":"HGNC:25802","ncbi_gene_id":79962,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DNAJC22","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC24","identifiers":{"aliases":["JJJ3"],"approved_symbol":"DNAJC24","ensembl_gene_id":"ENSG00000170946","hgnc_id":"HGNC:26979","ncbi_gene_id":120526,"previous_symbols":["ZCSL3","DPH4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC24","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC25","identifiers":{"aliases":["bA16L21.2.1"],"approved_symbol":"DNAJC25","ensembl_gene_id":"ENSG00000059769","hgnc_id":"HGNC:34187","ncbi_gene_id":548645,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAJC25","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC27","identifiers":{"aliases":["RabJS"],"approved_symbol":"DNAJC27","ensembl_gene_id":"ENSG00000115137","hgnc_id":"HGNC:30290","ncbi_gene_id":51277,"previous_symbols":["RBJ"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAJC27","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC27-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC27-AS1","identifiers":{"aliases":[],"approved_symbol":"DNAJC27-AS1","ensembl_gene_id":"ENSG00000224165","hgnc_id":"HGNC:42943","ncbi_gene_id":729723,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DNAJC27-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC28","identifiers":{"aliases":["C21orf78"],"approved_symbol":"DNAJC28","ensembl_gene_id":"ENSG00000177692","hgnc_id":"HGNC:1297","ncbi_gene_id":54943,"previous_symbols":["C21orf55"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC28","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC3","identifiers":{"aliases":["P58","P58IPK","HP58","ERdj6","p58(IPK)"],"approved_symbol":"DNAJC3","ensembl_gene_id":"ENSG00000102580","hgnc_id":"HGNC:9439","ncbi_gene_id":5611,"previous_symbols":["PRKRI"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC3","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC3-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC3-DT","identifiers":{"aliases":[],"approved_symbol":"DNAJC3-DT","ensembl_gene_id":"ENSG00000247400","hgnc_id":"HGNC:39808","ncbi_gene_id":100289274,"previous_symbols":["DNAJC3-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC3-DT","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC30","identifiers":{"aliases":[],"approved_symbol":"DNAJC30","ensembl_gene_id":"ENSG00000176410","hgnc_id":"HGNC:16410","ncbi_gene_id":84277,"previous_symbols":["WBSCR18"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC30","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC4","identifiers":{"aliases":["MCG18"],"approved_symbol":"DNAJC4","ensembl_gene_id":"ENSG00000110011","hgnc_id":"HGNC:5271","ncbi_gene_id":3338,"previous_symbols":["HSPF2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC4","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC5","identifiers":{"aliases":["FLJ00118","FLJ13070","DNAJC5A"],"approved_symbol":"DNAJC5","ensembl_gene_id":"ENSG00000101152","hgnc_id":"HGNC:16235","ncbi_gene_id":80331,"previous_symbols":["CLN4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC5","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC5B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC5B","identifiers":{"aliases":["MGC26226","CSP-beta"],"approved_symbol":"DNAJC5B","ensembl_gene_id":"ENSG00000147570","hgnc_id":"HGNC:24138","ncbi_gene_id":85479,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC5B","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC6","identifiers":{"aliases":["KIAA0473","PARK19"],"approved_symbol":"DNAJC6","ensembl_gene_id":"ENSG00000116675","hgnc_id":"HGNC:15469","ncbi_gene_id":9829,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC6","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC7","identifiers":{"aliases":["TPR2"],"approved_symbol":"DNAJC7","ensembl_gene_id":"ENSG00000168259","hgnc_id":"HGNC:12392","ncbi_gene_id":7266,"previous_symbols":["TTC2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC7","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC8","identifiers":{"aliases":["SPF31"],"approved_symbol":"DNAJC8","ensembl_gene_id":"ENSG00000126698","hgnc_id":"HGNC:15470","ncbi_gene_id":22826,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAJC8","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC9","identifiers":{"aliases":["JDD1","SB73"],"approved_symbol":"DNAJC9","ensembl_gene_id":"ENSG00000213551","hgnc_id":"HGNC:19123","ncbi_gene_id":23234,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC9","release_manifest":"api/v1.1/release_manifest.json"}},"DNAJC9-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAJC9-AS1","identifiers":{"aliases":["bA537A6.3"],"approved_symbol":"DNAJC9-AS1","ensembl_gene_id":"ENSG00000236756","hgnc_id":"HGNC:31432","ncbi_gene_id":414245,"previous_symbols":["C10orf103"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAJC9-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAL1","identifiers":{"aliases":["MGC12435","1700010H15RiK","CILD16"],"approved_symbol":"DNAL1","ensembl_gene_id":"ENSG00000119661","hgnc_id":"HGNC:23247","ncbi_gene_id":83544,"previous_symbols":["C14orf168"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNAL1","release_manifest":"api/v1.1/release_manifest.json"}},"DNAL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNAL4","identifiers":{"aliases":["dJ327J16","PIG27"],"approved_symbol":"DNAL4","ensembl_gene_id":"ENSG00000100246","hgnc_id":"HGNC:2955","ncbi_gene_id":10126,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNAL4","release_manifest":"api/v1.1/release_manifest.json"}},"DNALI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNALI1","identifiers":{"aliases":["P28","hp28","dJ423B22.5"],"approved_symbol":"DNALI1","ensembl_gene_id":"ENSG00000163879","hgnc_id":"HGNC:14353","ncbi_gene_id":7802,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNALI1","release_manifest":"api/v1.1/release_manifest.json"}},"DNASE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNASE1","identifiers":{"aliases":[],"approved_symbol":"DNASE1","ensembl_gene_id":"ENSG00000213918","hgnc_id":"HGNC:2956","ncbi_gene_id":1773,"previous_symbols":["DNL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNASE1","release_manifest":"api/v1.1/release_manifest.json"}},"DNASE1L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNASE1L1","identifiers":{"aliases":["DNAS1L1","XIB","DNASEX"],"approved_symbol":"DNASE1L1","ensembl_gene_id":"ENSG00000013563","hgnc_id":"HGNC:2957","ncbi_gene_id":1774,"previous_symbols":["DNL1L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNASE1L1","release_manifest":"api/v1.1/release_manifest.json"}},"DNASE1L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNASE1L2","identifiers":{"aliases":["DNAS1L2"],"approved_symbol":"DNASE1L2","ensembl_gene_id":"ENSG00000167968","hgnc_id":"HGNC:2958","ncbi_gene_id":1775,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DNASE1L2","release_manifest":"api/v1.1/release_manifest.json"}},"DNASE1L3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNASE1L3","identifiers":{"aliases":["DNAS1L3","LSD","D3"],"approved_symbol":"DNASE1L3","ensembl_gene_id":"ENSG00000163687","hgnc_id":"HGNC:2959","ncbi_gene_id":1776,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNASE1L3","release_manifest":"api/v1.1/release_manifest.json"}},"DNASE2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNASE2","identifiers":{"aliases":[],"approved_symbol":"DNASE2","ensembl_gene_id":"ENSG00000105612","hgnc_id":"HGNC:2960","ncbi_gene_id":1777,"previous_symbols":["DNL","DNL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNASE2","release_manifest":"api/v1.1/release_manifest.json"}},"DNASE2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNASE2B","identifiers":{"aliases":["DLAD"],"approved_symbol":"DNASE2B","ensembl_gene_id":"ENSG00000137976","hgnc_id":"HGNC:28875","ncbi_gene_id":58511,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNASE2B","release_manifest":"api/v1.1/release_manifest.json"}},"DND1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DND1","identifiers":{"aliases":["MGC34750","RBMS4"],"approved_symbol":"DND1","ensembl_gene_id":"ENSG00000256453","hgnc_id":"HGNC:23799","ncbi_gene_id":373863,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DND1","release_manifest":"api/v1.1/release_manifest.json"}},"DNER":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNER","identifiers":{"aliases":["UNQ26","bet"],"approved_symbol":"DNER","ensembl_gene_id":"ENSG00000187957","hgnc_id":"HGNC:24456","ncbi_gene_id":92737,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNER","release_manifest":"api/v1.1/release_manifest.json"}},"DNHD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNHD1","identifiers":{"aliases":["FLJ32752","FLJ46184","FLJ35709","DKFZp686J0796"],"approved_symbol":"DNHD1","ensembl_gene_id":"ENSG00000179532","hgnc_id":"HGNC:26532","ncbi_gene_id":144132,"previous_symbols":["DHCD1","C11orf47","DNHD1L","CCDC35"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNHD1","release_manifest":"api/v1.1/release_manifest.json"}},"DNLZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNLZ","identifiers":{"aliases":["RP11-413M3.2","ZIM17","bA413M3.2","TIMM15","HEP"],"approved_symbol":"DNLZ","ensembl_gene_id":"ENSG00000213221","hgnc_id":"HGNC:33879","ncbi_gene_id":728489,"previous_symbols":["C9orf151"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DNLZ","release_manifest":"api/v1.1/release_manifest.json"}},"DNM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNM1","identifiers":{"aliases":[],"approved_symbol":"DNM1","ensembl_gene_id":"ENSG00000106976","hgnc_id":"HGNC:2972","ncbi_gene_id":1759,"previous_symbols":["DNM"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L2_observed_same_context_perturbation","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":116},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"computational_replication","current_display_label":"Computational replication","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":14,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-07","label":"Independent computational replication is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-03 DMD-relevant functional validation"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":1.39988,"depmap_median_gene_effect":-0.2192872843255425,"moderate_dependency_flag":false,"observed_counteralignment":0.0023798166472955},"summary":"Priority C · context/calibration; observed DMD-prior counteralignment 0.00238; observed cells 116; integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNM1","detailed_audit_record":"gene/DNM1/audit","legacy_api_record":"api/v1/genes/DNM1.json","release_manifest":"api/v1.1/release_manifest.json"}},"DNM1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNM1L","identifiers":{"aliases":["DRP1","DVLP","HDYNIV","DYMPLE","VPS1"],"approved_symbol":"DNM1L","ensembl_gene_id":"ENSG00000087470","hgnc_id":"HGNC:2973","ncbi_gene_id":10059,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNM1L","release_manifest":"api/v1.1/release_manifest.json"}},"DNM1P35":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNM1P35","identifiers":{"aliases":["DNM1DN8-2"],"approved_symbol":"DNM1P35","ensembl_gene_id":"ENSG00000246877","hgnc_id":"HGNC:35182","ncbi_gene_id":100128285,"previous_symbols":["DNM1DN8@"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DNM1P35","release_manifest":"api/v1.1/release_manifest.json"}},"DNM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNM2","identifiers":{"aliases":["DYNII","DYN2","CMTDIB","CMTDI1","DI-CMTB","CMT2M"],"approved_symbol":"DNM2","ensembl_gene_id":"ENSG00000079805","hgnc_id":"HGNC:2974","ncbi_gene_id":1785,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core; NMD scope support direct sparse boundary","links":{"research_record":"gene/DNM2","release_manifest":"api/v1.1/release_manifest.json"}},"DNM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNM3","identifiers":{"aliases":["KIAA0820"],"approved_symbol":"DNM3","ensembl_gene_id":"ENSG00000197959","hgnc_id":"HGNC:29125","ncbi_gene_id":26052,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNM3","release_manifest":"api/v1.1/release_manifest.json"}},"DNM3OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNM3OS","identifiers":{"aliases":["MIR199A2HG"],"approved_symbol":"DNM3OS","ensembl_gene_id":"ENSG00000230630","hgnc_id":"HGNC:41228","ncbi_gene_id":100628315,"previous_symbols":["DNM3-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DNM3OS","release_manifest":"api/v1.1/release_manifest.json"}},"DNMBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNMBP","identifiers":{"aliases":["KIAA1010","Tuba","ARHGEF36"],"approved_symbol":"DNMBP","ensembl_gene_id":"ENSG00000107554","hgnc_id":"HGNC:30373","ncbi_gene_id":23268,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNMBP","release_manifest":"api/v1.1/release_manifest.json"}},"DNMBP-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNMBP-AS1","identifiers":{"aliases":["FLJ40792","bA287G8.2"],"approved_symbol":"DNMBP-AS1","ensembl_gene_id":"ENSG00000227695","hgnc_id":"HGNC:20431","ncbi_gene_id":100188954,"previous_symbols":["NCRNA00093"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNMBP-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DNMT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNMT1","identifiers":{"aliases":["MCMT","CXXC9"],"approved_symbol":"DNMT1","ensembl_gene_id":"ENSG00000130816","hgnc_id":"HGNC:2976","ncbi_gene_id":1786,"previous_symbols":["DNMT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNMT1","release_manifest":"api/v1.1/release_manifest.json"}},"DNMT3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNMT3A","identifiers":{"aliases":[],"approved_symbol":"DNMT3A","ensembl_gene_id":"ENSG00000119772","hgnc_id":"HGNC:2978","ncbi_gene_id":1788,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNMT3A","release_manifest":"api/v1.1/release_manifest.json"}},"DNMT3B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNMT3B","identifiers":{"aliases":[],"approved_symbol":"DNMT3B","ensembl_gene_id":"ENSG00000088305","hgnc_id":"HGNC:2979","ncbi_gene_id":1789,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNMT3B","release_manifest":"api/v1.1/release_manifest.json"}},"DNMT3L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNMT3L","identifiers":{"aliases":["MGC1090"],"approved_symbol":"DNMT3L","ensembl_gene_id":"ENSG00000142182","hgnc_id":"HGNC:2980","ncbi_gene_id":29947,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DNMT3L","release_manifest":"api/v1.1/release_manifest.json"}},"DNPEP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNPEP","identifiers":{"aliases":["DAP","ASPEP"],"approved_symbol":"DNPEP","ensembl_gene_id":"ENSG00000123992","hgnc_id":"HGNC:2981","ncbi_gene_id":23549,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNPEP","release_manifest":"api/v1.1/release_manifest.json"}},"DNPH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNPH1","identifiers":{"aliases":["rcl","dJ330M21.3"],"approved_symbol":"DNPH1","ensembl_gene_id":"ENSG00000112667","hgnc_id":"HGNC:21218","ncbi_gene_id":10591,"previous_symbols":["C6orf108"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNPH1","release_manifest":"api/v1.1/release_manifest.json"}},"DNTTIP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNTTIP1","identifiers":{"aliases":["dJ447F3.4","Tdif1"],"approved_symbol":"DNTTIP1","ensembl_gene_id":"ENSG00000101457","hgnc_id":"HGNC:16160","ncbi_gene_id":116092,"previous_symbols":["C20orf167"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNTTIP1","release_manifest":"api/v1.1/release_manifest.json"}},"DNTTIP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DNTTIP2","identifiers":{"aliases":["HSU15552","ERBP","TdIF2"],"approved_symbol":"DNTTIP2","ensembl_gene_id":"ENSG00000067334","hgnc_id":"HGNC:24013","ncbi_gene_id":30836,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DNTTIP2","release_manifest":"api/v1.1/release_manifest.json"}},"DOC2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOC2A","identifiers":{"aliases":[],"approved_symbol":"DOC2A","ensembl_gene_id":"ENSG00000149927","hgnc_id":"HGNC:2985","ncbi_gene_id":8448,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOC2A","release_manifest":"api/v1.1/release_manifest.json"}},"DOC2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOC2B","identifiers":{"aliases":[],"approved_symbol":"DOC2B","ensembl_gene_id":"ENSG00000272636","hgnc_id":"HGNC:2986","ncbi_gene_id":8447,"previous_symbols":["DOC2BL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOC2B","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK1","identifiers":{"aliases":["DOCK180","ced5"],"approved_symbol":"DOCK1","ensembl_gene_id":"ENSG00000150760","hgnc_id":"HGNC:2987","ncbi_gene_id":1793,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK1","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK10","identifiers":{"aliases":["ZIZ3","KIAA0694"],"approved_symbol":"DOCK10","ensembl_gene_id":"ENSG00000135905","hgnc_id":"HGNC:23479","ncbi_gene_id":55619,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK10","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK11","identifiers":{"aliases":["FLJ32122","FLJ43653","ZIZ2","ACG"],"approved_symbol":"DOCK11","ensembl_gene_id":"ENSG00000147251","hgnc_id":"HGNC:23483","ncbi_gene_id":139818,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK11","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK2","identifiers":{"aliases":["KIAA0209"],"approved_symbol":"DOCK2","ensembl_gene_id":"ENSG00000134516","hgnc_id":"HGNC:2988","ncbi_gene_id":1794,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK2","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK3","identifiers":{"aliases":["KIAA0299","MOCA","PBP"],"approved_symbol":"DOCK3","ensembl_gene_id":"ENSG00000088538","hgnc_id":"HGNC:2989","ncbi_gene_id":1795,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK3","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK4","identifiers":{"aliases":["FLJ34238","KIAA0716"],"approved_symbol":"DOCK4","ensembl_gene_id":"ENSG00000128512","hgnc_id":"HGNC:19192","ncbi_gene_id":9732,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK4","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK4-AS1","identifiers":{"aliases":[],"approved_symbol":"DOCK4-AS1","ensembl_gene_id":"ENSG00000225572","hgnc_id":"HGNC:40876","ncbi_gene_id":100506413,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DOCK4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK5","identifiers":{"aliases":["FLJ21034"],"approved_symbol":"DOCK5","ensembl_gene_id":"ENSG00000147459","hgnc_id":"HGNC:23476","ncbi_gene_id":80005,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK5","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK6","identifiers":{"aliases":["KIAA1395","ZIR1"],"approved_symbol":"DOCK6","ensembl_gene_id":"ENSG00000130158","hgnc_id":"HGNC:19189","ncbi_gene_id":57572,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK6","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK7","identifiers":{"aliases":["KIAA1771","ZIR2"],"approved_symbol":"DOCK7","ensembl_gene_id":"ENSG00000116641","hgnc_id":"HGNC:19190","ncbi_gene_id":85440,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK7","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK8","identifiers":{"aliases":["FLJ00026","FLJ00152","ZIR8","FLJ00346"],"approved_symbol":"DOCK8","ensembl_gene_id":"ENSG00000107099","hgnc_id":"HGNC:19191","ncbi_gene_id":81704,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK8","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK8-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK8-AS1","identifiers":{"aliases":["FLJ31158"],"approved_symbol":"DOCK8-AS1","ensembl_gene_id":"ENSG00000183784","hgnc_id":"HGNC:26436","ncbi_gene_id":157983,"previous_symbols":["C9orf66"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK8-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK9","identifiers":{"aliases":["KIAA1058","ZIZ1"],"approved_symbol":"DOCK9","ensembl_gene_id":"ENSG00000088387","hgnc_id":"HGNC:14132","ncbi_gene_id":23348,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK9","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK9-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK9-AS1","identifiers":{"aliases":[],"approved_symbol":"DOCK9-AS1","ensembl_gene_id":"ENSG00000229918","hgnc_id":"HGNC:40672","ncbi_gene_id":100874096,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK9-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DOCK9-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOCK9-DT","identifiers":{"aliases":[],"approved_symbol":"DOCK9-DT","ensembl_gene_id":"ENSG00000260992","hgnc_id":"HGNC:43696","ncbi_gene_id":100861541,"previous_symbols":["DOCK9-AS2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOCK9-DT","release_manifest":"api/v1.1/release_manifest.json"}},"DOHH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOHH","identifiers":{"aliases":["MGC4293"],"approved_symbol":"DOHH","ensembl_gene_id":"ENSG00000129932","hgnc_id":"HGNC:28662","ncbi_gene_id":83475,"previous_symbols":["HLRC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DOHH","release_manifest":"api/v1.1/release_manifest.json"}},"DOK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK1","identifiers":{"aliases":["p62dok"],"approved_symbol":"DOK1","ensembl_gene_id":"ENSG00000115325","hgnc_id":"HGNC:2990","ncbi_gene_id":1796,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DOK1","release_manifest":"api/v1.1/release_manifest.json"}},"DOK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK2","identifiers":{"aliases":["p56dok-2","Dok-2"],"approved_symbol":"DOK2","ensembl_gene_id":"ENSG00000147443","hgnc_id":"HGNC:2991","ncbi_gene_id":9046,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOK2","release_manifest":"api/v1.1/release_manifest.json"}},"DOK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK3","identifiers":{"aliases":["FLJ22570"],"approved_symbol":"DOK3","ensembl_gene_id":"ENSG00000146094","hgnc_id":"HGNC:24583","ncbi_gene_id":79930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DOK3","release_manifest":"api/v1.1/release_manifest.json"}},"DOK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK4","identifiers":{"aliases":["FLJ10488"],"approved_symbol":"DOK4","ensembl_gene_id":"ENSG00000125170","hgnc_id":"HGNC:19868","ncbi_gene_id":55715,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DOK4","release_manifest":"api/v1.1/release_manifest.json"}},"DOK5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK5","identifiers":{"aliases":["dJ805C22.1"],"approved_symbol":"DOK5","ensembl_gene_id":"ENSG00000101134","hgnc_id":"HGNC:16173","ncbi_gene_id":55816,"previous_symbols":["C20orf180"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOK5","release_manifest":"api/v1.1/release_manifest.json"}},"DOK6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK6","identifiers":{"aliases":["MGC20785","HsT3226"],"approved_symbol":"DOK6","ensembl_gene_id":"ENSG00000206052","hgnc_id":"HGNC:28301","ncbi_gene_id":220164,"previous_symbols":["DOK5L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOK6","release_manifest":"api/v1.1/release_manifest.json"}},"DOK7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOK7","identifiers":{"aliases":["FLJ33718","FLJ39137","Dok-7"],"approved_symbol":"DOK7","ensembl_gene_id":"ENSG00000175920","hgnc_id":"HGNC:26594","ncbi_gene_id":285489,"previous_symbols":["C4orf25"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOK7","release_manifest":"api/v1.1/release_manifest.json"}},"DOLK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOLK","identifiers":{"aliases":["KIAA1094","DK1"],"approved_symbol":"DOLK","ensembl_gene_id":"ENSG00000175283","hgnc_id":"HGNC:23406","ncbi_gene_id":22845,"previous_symbols":["TMEM15"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.079918,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DOLK","release_manifest":"api/v1.1/release_manifest.json"}},"DOLPP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOLPP1","identifiers":{"aliases":["LSFR2"],"approved_symbol":"DOLPP1","ensembl_gene_id":"ENSG00000167130","hgnc_id":"HGNC:29565","ncbi_gene_id":57171,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOLPP1","release_manifest":"api/v1.1/release_manifest.json"}},"DONSON":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DONSON","identifiers":{"aliases":["B17","C2TA","DKFZP434M035"],"approved_symbol":"DONSON","ensembl_gene_id":"ENSG00000159147","hgnc_id":"HGNC:2993","ncbi_gene_id":29980,"previous_symbols":["C21orf60"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DONSON","release_manifest":"api/v1.1/release_manifest.json"}},"DOP1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOP1A","identifiers":{"aliases":["dJ202D23.2"],"approved_symbol":"DOP1A","ensembl_gene_id":"ENSG00000083097","hgnc_id":"HGNC:21194","ncbi_gene_id":23033,"previous_symbols":["KIAA1117","DOPEY1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOP1A","release_manifest":"api/v1.1/release_manifest.json"}},"DOP1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOP1B","identifiers":{"aliases":["KIAA0933"],"approved_symbol":"DOP1B","ensembl_gene_id":"ENSG00000142197","hgnc_id":"HGNC:1291","ncbi_gene_id":9980,"previous_symbols":["C21orf5","DOPEY2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DOP1B","release_manifest":"api/v1.1/release_manifest.json"}},"DOT1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DOT1L","identifiers":{"aliases":["KIAA1814","DOT1","KMT4"],"approved_symbol":"DOT1L","ensembl_gene_id":"ENSG00000104885","hgnc_id":"HGNC:24948","ncbi_gene_id":84444,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DOT1L","release_manifest":"api/v1.1/release_manifest.json"}},"DPAGT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPAGT1","identifiers":{"aliases":["GPT","D11S366","DGPT","ALG7","CDG-Ij"],"approved_symbol":"DPAGT1","ensembl_gene_id":"ENSG00000172269","hgnc_id":"HGNC:2995","ncbi_gene_id":1798,"previous_symbols":["DPAGT2","DPAGT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPAGT1","release_manifest":"api/v1.1/release_manifest.json"}},"DPCD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPCD","identifiers":{"aliases":["DKFZP566F084","RP11-529I10.4"],"approved_symbol":"DPCD","ensembl_gene_id":"ENSG00000166171","hgnc_id":"HGNC:24542","ncbi_gene_id":25911,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DPCD","release_manifest":"api/v1.1/release_manifest.json"}},"DPEP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPEP1","identifiers":{"aliases":[],"approved_symbol":"DPEP1","ensembl_gene_id":"ENSG00000015413","hgnc_id":"HGNC:3002","ncbi_gene_id":1800,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DPEP1","release_manifest":"api/v1.1/release_manifest.json"}},"DPEP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPEP2","identifiers":{"aliases":[],"approved_symbol":"DPEP2","ensembl_gene_id":"ENSG00000167261","hgnc_id":"HGNC:23028","ncbi_gene_id":64174,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPEP2","release_manifest":"api/v1.1/release_manifest.json"}},"DPF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPF1","identifiers":{"aliases":["neuro-d4","NEUD4","BAF45b","SMARCG1"],"approved_symbol":"DPF1","ensembl_gene_id":"ENSG00000011332","hgnc_id":"HGNC:20225","ncbi_gene_id":8193,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPF1","release_manifest":"api/v1.1/release_manifest.json"}},"DPF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPF2","identifiers":{"aliases":["ubi-d4","BAF45d","SMARCG2"],"approved_symbol":"DPF2","ensembl_gene_id":"ENSG00000133884","hgnc_id":"HGNC:9964","ncbi_gene_id":5977,"previous_symbols":["REQ"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPF2","release_manifest":"api/v1.1/release_manifest.json"}},"DPF3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPF3","identifiers":{"aliases":["cer-d4","Cerd4","FLJ14079","BAF45c","SMARCG3"],"approved_symbol":"DPF3","ensembl_gene_id":"ENSG00000205683","hgnc_id":"HGNC:17427","ncbi_gene_id":8110,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPF3","release_manifest":"api/v1.1/release_manifest.json"}},"DPH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH1","identifiers":{"aliases":["OVCA1"],"approved_symbol":"DPH1","ensembl_gene_id":"ENSG00000108963","hgnc_id":"HGNC:3003","ncbi_gene_id":1801,"previous_symbols":["DPH2L","DPH2L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":true,"effect_size":0.63308,"fdr":0.084047,"context":"GSE293514_myoblast_fusion_screen","interpretation":"screen_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPH1","release_manifest":"api/v1.1/release_manifest.json"}},"DPH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH2","identifiers":{"aliases":[],"approved_symbol":"DPH2","ensembl_gene_id":"ENSG00000132768","hgnc_id":"HGNC:3004","ncbi_gene_id":1802,"previous_symbols":["DPH2L2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.50006,"fdr":0.302827,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPH2","release_manifest":"api/v1.1/release_manifest.json"}},"DPH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH3","identifiers":{"aliases":["DESR1","DELGIP1","MGC20197","KTI11","DELGIP","DPH3A"],"approved_symbol":"DPH3","ensembl_gene_id":"ENSG00000154813","hgnc_id":"HGNC:27717","ncbi_gene_id":285381,"previous_symbols":["ZCSL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPH3","release_manifest":"api/v1.1/release_manifest.json"}},"DPH5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH5","identifiers":{"aliases":["CGI-30"],"approved_symbol":"DPH5","ensembl_gene_id":"ENSG00000117543","hgnc_id":"HGNC:24270","ncbi_gene_id":51611,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPH5","release_manifest":"api/v1.1/release_manifest.json"}},"DPH6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH6","identifiers":{"aliases":["MGC14798"],"approved_symbol":"DPH6","ensembl_gene_id":"ENSG00000134146","hgnc_id":"HGNC:30543","ncbi_gene_id":89978,"previous_symbols":["ATPBD4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPH6","release_manifest":"api/v1.1/release_manifest.json"}},"DPH6-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH6-DT","identifiers":{"aliases":["uc.382"],"approved_symbol":"DPH6-DT","ensembl_gene_id":"ENSG00000248079","hgnc_id":"HGNC:44147","ncbi_gene_id":100507466,"previous_symbols":["ATPBD4-AS1","DPH6-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DPH6-DT","release_manifest":"api/v1.1/release_manifest.json"}},"DPH7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPH7","identifiers":{"aliases":["FLJ90634","RRT2"],"approved_symbol":"DPH7","ensembl_gene_id":"ENSG00000148399","hgnc_id":"HGNC:25199","ncbi_gene_id":92715,"previous_symbols":["C9orf112","WDR85"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPH7","release_manifest":"api/v1.1/release_manifest.json"}},"DPM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPM1","identifiers":{"aliases":["MPDS","CDGIE"],"approved_symbol":"DPM1","ensembl_gene_id":"ENSG00000000419","hgnc_id":"HGNC:3005","ncbi_gene_id":8813,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPM1","release_manifest":"api/v1.1/release_manifest.json"}},"DPM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPM2","identifiers":{"aliases":["MGC21559","MGC111193"],"approved_symbol":"DPM2","ensembl_gene_id":"ENSG00000136908","hgnc_id":"HGNC:3006","ncbi_gene_id":8818,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.31677,"fdr":0.887444,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPM2","release_manifest":"api/v1.1/release_manifest.json"}},"DPM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPM3","identifiers":{"aliases":["MGC34275","MGC125904","MGC125905"],"approved_symbol":"DPM3","ensembl_gene_id":"ENSG00000179085","hgnc_id":"HGNC:3007","ncbi_gene_id":54344,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPM3","release_manifest":"api/v1.1/release_manifest.json"}},"DPP10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP10","identifiers":{"aliases":["DPRP3","DPL2","DPPY"],"approved_symbol":"DPP10","ensembl_gene_id":"ENSG00000175497","hgnc_id":"HGNC:20823","ncbi_gene_id":57628,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPP10","release_manifest":"api/v1.1/release_manifest.json"}},"DPP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP3","identifiers":{"aliases":[],"approved_symbol":"DPP3","ensembl_gene_id":"ENSG00000254986","hgnc_id":"HGNC:3008","ncbi_gene_id":10072,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPP3","release_manifest":"api/v1.1/release_manifest.json"}},"DPP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP4","identifiers":{"aliases":["DPPIV"],"approved_symbol":"DPP4","ensembl_gene_id":"ENSG00000197635","hgnc_id":"HGNC:3009","ncbi_gene_id":1803,"previous_symbols":["CD26","ADCP2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPP4","release_manifest":"api/v1.1/release_manifest.json"}},"DPP6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP6","identifiers":{"aliases":["DPPX","DPL1"],"approved_symbol":"DPP6","ensembl_gene_id":"ENSG00000130226","hgnc_id":"HGNC:3010","ncbi_gene_id":1804,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DPP6","release_manifest":"api/v1.1/release_manifest.json"}},"DPP7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP7","identifiers":{"aliases":["DPPII","DPP2"],"approved_symbol":"DPP7","ensembl_gene_id":"ENSG00000176978","hgnc_id":"HGNC:14892","ncbi_gene_id":29952,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPP7","release_manifest":"api/v1.1/release_manifest.json"}},"DPP8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP8","identifiers":{"aliases":["DP8","DPRP1","MSTP141","FLJ14920","FLJ20283","MGC26191"],"approved_symbol":"DPP8","ensembl_gene_id":"ENSG00000074603","hgnc_id":"HGNC:16490","ncbi_gene_id":54878,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPP8","release_manifest":"api/v1.1/release_manifest.json"}},"DPP9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP9","identifiers":{"aliases":[],"approved_symbol":"DPP9","ensembl_gene_id":"ENSG00000142002","hgnc_id":"HGNC:18648","ncbi_gene_id":91039,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPP9","release_manifest":"api/v1.1/release_manifest.json"}},"DPP9-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPP9-AS1","identifiers":{"aliases":[],"approved_symbol":"DPP9-AS1","ensembl_gene_id":"ENSG00000205790","hgnc_id":"HGNC:50706","ncbi_gene_id":100131094,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DPP9-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DPPA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPPA2","identifiers":{"aliases":["PESCRG1","CT100"],"approved_symbol":"DPPA2","ensembl_gene_id":"ENSG00000163530","hgnc_id":"HGNC:19197","ncbi_gene_id":151871,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DPPA2","release_manifest":"api/v1.1/release_manifest.json"}},"DPPA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPPA3","identifiers":{"aliases":["Stella","Pgc7"],"approved_symbol":"DPPA3","ensembl_gene_id":"ENSG00000187569","hgnc_id":"HGNC:19199","ncbi_gene_id":359787,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DPPA3","release_manifest":"api/v1.1/release_manifest.json"}},"DPRX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPRX","identifiers":{"aliases":[],"approved_symbol":"DPRX","ensembl_gene_id":"ENSG00000204595","hgnc_id":"HGNC:32166","ncbi_gene_id":503834,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPRX","release_manifest":"api/v1.1/release_manifest.json"}},"DPT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPT","identifiers":{"aliases":[],"approved_symbol":"DPT","ensembl_gene_id":"ENSG00000143196","hgnc_id":"HGNC:3011","ncbi_gene_id":1805,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPT","release_manifest":"api/v1.1/release_manifest.json"}},"DPY19L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPY19L1","identifiers":{"aliases":["KIAA0877"],"approved_symbol":"DPY19L1","ensembl_gene_id":"ENSG00000173852","hgnc_id":"HGNC:22205","ncbi_gene_id":23333,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPY19L1","release_manifest":"api/v1.1/release_manifest.json"}},"DPY19L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPY19L2","identifiers":{"aliases":["FLJ32949","SPATA34"],"approved_symbol":"DPY19L2","ensembl_gene_id":"ENSG00000177990","hgnc_id":"HGNC:19414","ncbi_gene_id":283417,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DPY19L2","release_manifest":"api/v1.1/release_manifest.json"}},"DPY19L3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPY19L3","identifiers":{"aliases":[],"approved_symbol":"DPY19L3","ensembl_gene_id":"ENSG00000178904","hgnc_id":"HGNC:27120","ncbi_gene_id":147991,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DPY19L3","release_manifest":"api/v1.1/release_manifest.json"}},"DPY19L4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPY19L4","identifiers":{"aliases":[],"approved_symbol":"DPY19L4","ensembl_gene_id":"ENSG00000156162","hgnc_id":"HGNC:27829","ncbi_gene_id":286148,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPY19L4","release_manifest":"api/v1.1/release_manifest.json"}},"DPY30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPY30","identifiers":{"aliases":["Saf19","HDPY-30","Cps25"],"approved_symbol":"DPY30","ensembl_gene_id":"ENSG00000162961","hgnc_id":"HGNC:24590","ncbi_gene_id":84661,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPY30","release_manifest":"api/v1.1/release_manifest.json"}},"DPYD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYD","identifiers":{"aliases":["DPD","DHPDHase"],"approved_symbol":"DPYD","ensembl_gene_id":"ENSG00000188641","hgnc_id":"HGNC:3012","ncbi_gene_id":1806,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPYD","release_manifest":"api/v1.1/release_manifest.json"}},"DPYD-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYD-AS1","identifiers":{"aliases":[],"approved_symbol":"DPYD-AS1","ensembl_gene_id":"ENSG00000232878","hgnc_id":"HGNC:40195","ncbi_gene_id":100873932,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DPYD-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"DPYS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYS","identifiers":{"aliases":["DHPase"],"approved_symbol":"DPYS","ensembl_gene_id":"ENSG00000147647","hgnc_id":"HGNC:3013","ncbi_gene_id":1807,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPYS","release_manifest":"api/v1.1/release_manifest.json"}},"DPYSL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYSL2","identifiers":{"aliases":["DRP-2","DHPRP2","CRMP2","DRP2"],"approved_symbol":"DPYSL2","ensembl_gene_id":"ENSG00000092964","hgnc_id":"HGNC:3014","ncbi_gene_id":1808,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPYSL2","release_manifest":"api/v1.1/release_manifest.json"}},"DPYSL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYSL3","identifiers":{"aliases":["DRP-3","ULIP","CRMP4"],"approved_symbol":"DPYSL3","ensembl_gene_id":"ENSG00000113657","hgnc_id":"HGNC:3015","ncbi_gene_id":1809,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPYSL3","release_manifest":"api/v1.1/release_manifest.json"}},"DPYSL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYSL4","identifiers":{"aliases":["ULIP4","DRP-4","CRMP3"],"approved_symbol":"DPYSL4","ensembl_gene_id":"ENSG00000151640","hgnc_id":"HGNC:3016","ncbi_gene_id":10570,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPYSL4","release_manifest":"api/v1.1/release_manifest.json"}},"DPYSL5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DPYSL5","identifiers":{"aliases":["CRMP5","Ulip6","CRMP-5","CRAM","CV2"],"approved_symbol":"DPYSL5","ensembl_gene_id":"ENSG00000157851","hgnc_id":"HGNC:20637","ncbi_gene_id":56896,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DPYSL5","release_manifest":"api/v1.1/release_manifest.json"}},"DQX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DQX1","identifiers":{"aliases":["FLJ23757"],"approved_symbol":"DQX1","ensembl_gene_id":"ENSG00000144045","hgnc_id":"HGNC:20410","ncbi_gene_id":165545,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DQX1","release_manifest":"api/v1.1/release_manifest.json"}},"DR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DR1","identifiers":{"aliases":["NC2-BETA","NC2B","NCB2"],"approved_symbol":"DR1","ensembl_gene_id":"ENSG00000117505","hgnc_id":"HGNC:3017","ncbi_gene_id":1810,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DR1","release_manifest":"api/v1.1/release_manifest.json"}},"DRAIC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRAIC","identifiers":{"aliases":[],"approved_symbol":"DRAIC","ensembl_gene_id":"ENSG00000245750","hgnc_id":"HGNC:27082","ncbi_gene_id":145837,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRAIC","release_manifest":"api/v1.1/release_manifest.json"}},"DRAM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRAM1","identifiers":{"aliases":["FLJ11259","DRAM"],"approved_symbol":"DRAM1","ensembl_gene_id":"ENSG00000136048","hgnc_id":"HGNC:25645","ncbi_gene_id":55332,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRAM1","release_manifest":"api/v1.1/release_manifest.json"}},"DRAM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRAM2","identifiers":{"aliases":["MGC54289","PRO180","WWFQ154","RP5-1180E21.1"],"approved_symbol":"DRAM2","ensembl_gene_id":"ENSG00000156171","hgnc_id":"HGNC:28769","ncbi_gene_id":128338,"previous_symbols":["TMEM77"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRAM2","release_manifest":"api/v1.1/release_manifest.json"}},"DRAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRAP1","identifiers":{"aliases":["NC2-alpha"],"approved_symbol":"DRAP1","ensembl_gene_id":"ENSG00000175550","hgnc_id":"HGNC:3019","ncbi_gene_id":10589,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":true,"effect_size":2.5053,"fdr":0.00055,"context":"GSE293514_myoblast_fusion_screen","interpretation":"screen_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRAP1","release_manifest":"api/v1.1/release_manifest.json"}},"DRAXIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRAXIN","identifiers":{"aliases":["FLJ34999","Neucrin"],"approved_symbol":"DRAXIN","ensembl_gene_id":"ENSG00000162490","hgnc_id":"HGNC:25054","ncbi_gene_id":374946,"previous_symbols":["C1orf187"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DRAXIN","release_manifest":"api/v1.1/release_manifest.json"}},"DRC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRC1","identifiers":{"aliases":["MGC16372","FLJ32660","CILD21"],"approved_symbol":"DRC1","ensembl_gene_id":"ENSG00000157856","hgnc_id":"HGNC:24245","ncbi_gene_id":92749,"previous_symbols":["C2orf39","CCDC164"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DRC1","release_manifest":"api/v1.1/release_manifest.json"}},"DRC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRC3","identifiers":{"aliases":["DKFZP586M1120","CFAP134"],"approved_symbol":"DRC3","ensembl_gene_id":"ENSG00000171962","hgnc_id":"HGNC:25384","ncbi_gene_id":83450,"previous_symbols":["LRRC48"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRC3","release_manifest":"api/v1.1/release_manifest.json"}},"DRD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRD1","identifiers":{"aliases":["D1R"],"approved_symbol":"DRD1","ensembl_gene_id":"ENSG00000184845","hgnc_id":"HGNC:3020","ncbi_gene_id":1812,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRD1","release_manifest":"api/v1.1/release_manifest.json"}},"DRD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRD2","identifiers":{"aliases":["D2R"],"approved_symbol":"DRD2","ensembl_gene_id":"ENSG00000149295","hgnc_id":"HGNC:3023","ncbi_gene_id":1813,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DRD2","release_manifest":"api/v1.1/release_manifest.json"}},"DRD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRD4","identifiers":{"aliases":[],"approved_symbol":"DRD4","ensembl_gene_id":"ENSG00000069696","hgnc_id":"HGNC:3025","ncbi_gene_id":1815,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRD4","release_manifest":"api/v1.1/release_manifest.json"}},"DRG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRG1","identifiers":{"aliases":[],"approved_symbol":"DRG1","ensembl_gene_id":"ENSG00000185721","hgnc_id":"HGNC:3029","ncbi_gene_id":4733,"previous_symbols":["NEDD3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.16043,"fdr":0.904919,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRG1","release_manifest":"api/v1.1/release_manifest.json"}},"DRG2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRG2","identifiers":{"aliases":[],"approved_symbol":"DRG2","ensembl_gene_id":"ENSG00000108591","hgnc_id":"HGNC:3030","ncbi_gene_id":1819,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRG2","release_manifest":"api/v1.1/release_manifest.json"}},"DRICH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRICH1","identifiers":{"aliases":[],"approved_symbol":"DRICH1","ensembl_gene_id":"ENSG00000189269","hgnc_id":"HGNC:28031","ncbi_gene_id":51233,"previous_symbols":["C22orf43"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DRICH1","release_manifest":"api/v1.1/release_manifest.json"}},"DROSHA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DROSHA","identifiers":{"aliases":["RNASE3L","Etohi2","HSA242976","RN3"],"approved_symbol":"DROSHA","ensembl_gene_id":"ENSG00000113360","hgnc_id":"HGNC:17904","ncbi_gene_id":29102,"previous_symbols":["RNASEN"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DROSHA","release_manifest":"api/v1.1/release_manifest.json"}},"DRP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DRP2","identifiers":{"aliases":[],"approved_symbol":"DRP2","ensembl_gene_id":"ENSG00000102385","hgnc_id":"HGNC:3032","ncbi_gene_id":1821,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DRP2","release_manifest":"api/v1.1/release_manifest.json"}},"DSC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSC2","identifiers":{"aliases":["CDHF2"],"approved_symbol":"DSC2","ensembl_gene_id":"ENSG00000134755","hgnc_id":"HGNC:3036","ncbi_gene_id":1824,"previous_symbols":["DSC3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSC2","release_manifest":"api/v1.1/release_manifest.json"}},"DSCAM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSCAM","identifiers":{"aliases":["CHD2-42","CHD2-52"],"approved_symbol":"DSCAM","ensembl_gene_id":"ENSG00000171587","hgnc_id":"HGNC:3039","ncbi_gene_id":1826,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSCAM","release_manifest":"api/v1.1/release_manifest.json"}},"DSCAML1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSCAML1","identifiers":{"aliases":["KIAA1132"],"approved_symbol":"DSCAML1","ensembl_gene_id":"ENSG00000177103","hgnc_id":"HGNC:14656","ncbi_gene_id":57453,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DSCAML1","release_manifest":"api/v1.1/release_manifest.json"}},"DSCAS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSCAS","identifiers":{"aliases":[],"approved_symbol":"DSCAS","ensembl_gene_id":"ENSG00000265888","hgnc_id":"HGNC:51116","ncbi_gene_id":101927698,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSCAS","release_manifest":"api/v1.1/release_manifest.json"}},"DSCC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSCC1","identifiers":{"aliases":["DCC1","hDCC1","MGC5528"],"approved_symbol":"DSCC1","ensembl_gene_id":"ENSG00000136982","hgnc_id":"HGNC:24453","ncbi_gene_id":79075,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DSCC1","release_manifest":"api/v1.1/release_manifest.json"}},"DSCR9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSCR9","identifiers":{"aliases":["NCRNA00038"],"approved_symbol":"DSCR9","ensembl_gene_id":"ENSG00000230366","hgnc_id":"HGNC:16301","ncbi_gene_id":257203,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSCR9","release_manifest":"api/v1.1/release_manifest.json"}},"DSE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSE","identifiers":{"aliases":["DSEPI","DS-Epi1"],"approved_symbol":"DSE","ensembl_gene_id":"ENSG00000111817","hgnc_id":"HGNC:21144","ncbi_gene_id":29940,"previous_symbols":["SART2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSE","release_manifest":"api/v1.1/release_manifest.json"}},"DSEL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSEL","identifiers":{"aliases":["NCAG1","FLJ11477","DE-epi2"],"approved_symbol":"DSEL","ensembl_gene_id":"ENSG00000171451","hgnc_id":"HGNC:18144","ncbi_gene_id":92126,"previous_symbols":["C18orf4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSEL","release_manifest":"api/v1.1/release_manifest.json"}},"DSG2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSG2","identifiers":{"aliases":["CDHF5"],"approved_symbol":"DSG2","ensembl_gene_id":"ENSG00000046604","hgnc_id":"HGNC:3049","ncbi_gene_id":1829,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSG2","release_manifest":"api/v1.1/release_manifest.json"}},"DSN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSN1","identifiers":{"aliases":["dJ469A13.2","MIS13","KNL3","hKNL-3"],"approved_symbol":"DSN1","ensembl_gene_id":"ENSG00000149636","hgnc_id":"HGNC:16165","ncbi_gene_id":79980,"previous_symbols":["C20orf172"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSN1","release_manifest":"api/v1.1/release_manifest.json"}},"DSP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSP","identifiers":{"aliases":["KPPS2","PPKS2","DPI","DPII","DP"],"approved_symbol":"DSP","ensembl_gene_id":"ENSG00000096696","hgnc_id":"HGNC:3052","ncbi_gene_id":1832,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DSP","release_manifest":"api/v1.1/release_manifest.json"}},"DST":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DST","identifiers":{"aliases":["BP240","KIAA0728","FLJ21489","FLJ13425","FLJ32235","FLJ30627","CATX-15","BPA","MACF2"],"approved_symbol":"DST","ensembl_gene_id":"ENSG00000151914","hgnc_id":"HGNC:1090","ncbi_gene_id":667,"previous_symbols":["BPAG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DST","release_manifest":"api/v1.1/release_manifest.json"}},"DSTN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSTN","identifiers":{"aliases":["ADF","ACTDP"],"approved_symbol":"DSTN","ensembl_gene_id":"ENSG00000125868","hgnc_id":"HGNC:15750","ncbi_gene_id":11034,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DSTN","release_manifest":"api/v1.1/release_manifest.json"}},"DSTYK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DSTYK","identifiers":{"aliases":["KIAA0472","DustyPK","RIP5"],"approved_symbol":"DSTYK","ensembl_gene_id":"ENSG00000133059","hgnc_id":"HGNC:29043","ncbi_gene_id":25778,"previous_symbols":["RIPK5","SPG23"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DSTYK","release_manifest":"api/v1.1/release_manifest.json"}},"DTD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTD1","identifiers":{"aliases":["DUEB","MGC119131","MGC41905","bA379J5.3","bA555E18.1","pqn-68"],"approved_symbol":"DTD1","ensembl_gene_id":"ENSG00000125821","hgnc_id":"HGNC:16219","ncbi_gene_id":92675,"previous_symbols":["C20orf88","HARS2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTD1","release_manifest":"api/v1.1/release_manifest.json"}},"DTD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTD2","identifiers":{"aliases":["MGC9912"],"approved_symbol":"DTD2","ensembl_gene_id":"ENSG00000129480","hgnc_id":"HGNC:20277","ncbi_gene_id":112487,"previous_symbols":["C14orf126"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTD2","release_manifest":"api/v1.1/release_manifest.json"}},"DTHD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTHD1","identifiers":{"aliases":["FLJ16686"],"approved_symbol":"DTHD1","ensembl_gene_id":"ENSG00000197057","hgnc_id":"HGNC:37261","ncbi_gene_id":401124,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DTHD1","release_manifest":"api/v1.1/release_manifest.json"}},"DTL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTL","identifiers":{"aliases":["RAMP","L2DTL","DCAF2","CDT2"],"approved_symbol":"DTL","ensembl_gene_id":"ENSG00000143476","hgnc_id":"HGNC:30288","ncbi_gene_id":51514,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTL","release_manifest":"api/v1.1/release_manifest.json"}},"DTNA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTNA","identifiers":{"aliases":["D18S892E","DTN","DTN-1","DTN-2","DTN-3","DRP3"],"approved_symbol":"DTNA","ensembl_gene_id":"ENSG00000134769","hgnc_id":"HGNC:3057","ncbi_gene_id":1837,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTNA","release_manifest":"api/v1.1/release_manifest.json"}},"DTNB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTNB","identifiers":{"aliases":[],"approved_symbol":"DTNB","ensembl_gene_id":"ENSG00000138101","hgnc_id":"HGNC:3058","ncbi_gene_id":1838,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTNB","release_manifest":"api/v1.1/release_manifest.json"}},"DTNBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTNBP1","identifiers":{"aliases":["Dysbindin","My031","HPS7","DBND","BLOC1S8"],"approved_symbol":"DTNBP1","ensembl_gene_id":"ENSG00000047579","hgnc_id":"HGNC:17328","ncbi_gene_id":84062,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTNBP1","release_manifest":"api/v1.1/release_manifest.json"}},"DTWD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTWD1","identifiers":{"aliases":["MDS009","MGC111207"],"approved_symbol":"DTWD1","ensembl_gene_id":"ENSG00000104047","hgnc_id":"HGNC:30926","ncbi_gene_id":56986,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTWD1","release_manifest":"api/v1.1/release_manifest.json"}},"DTWD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTWD2","identifiers":{"aliases":["FLJ33977"],"approved_symbol":"DTWD2","ensembl_gene_id":"ENSG00000169570","hgnc_id":"HGNC:19334","ncbi_gene_id":285605,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTWD2","release_manifest":"api/v1.1/release_manifest.json"}},"DTX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTX1","identifiers":{"aliases":["hDx-1","RNF140"],"approved_symbol":"DTX1","ensembl_gene_id":"ENSG00000135144","hgnc_id":"HGNC:3060","ncbi_gene_id":1840,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTX1","release_manifest":"api/v1.1/release_manifest.json"}},"DTX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTX2","identifiers":{"aliases":["RNF58","KIAA1528"],"approved_symbol":"DTX2","ensembl_gene_id":"ENSG00000091073","hgnc_id":"HGNC:15973","ncbi_gene_id":113878,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTX2","release_manifest":"api/v1.1/release_manifest.json"}},"DTX3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTX3","identifiers":{"aliases":["FLJ34766","RNF154"],"approved_symbol":"DTX3","ensembl_gene_id":"ENSG00000178498","hgnc_id":"HGNC:24457","ncbi_gene_id":196403,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTX3","release_manifest":"api/v1.1/release_manifest.json"}},"DTX3L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTX3L","identifiers":{"aliases":["BBAP","RNF143"],"approved_symbol":"DTX3L","ensembl_gene_id":"ENSG00000163840","hgnc_id":"HGNC:30323","ncbi_gene_id":151636,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTX3L","release_manifest":"api/v1.1/release_manifest.json"}},"DTX4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTX4","identifiers":{"aliases":["KIAA0937","RNF155"],"approved_symbol":"DTX4","ensembl_gene_id":"ENSG00000110042","hgnc_id":"HGNC:29151","ncbi_gene_id":23220,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTX4","release_manifest":"api/v1.1/release_manifest.json"}},"DTYMK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DTYMK","identifiers":{"aliases":["CDC8","TYMK","TMPK"],"approved_symbol":"DTYMK","ensembl_gene_id":"ENSG00000168393","hgnc_id":"HGNC:3061","ncbi_gene_id":1841,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DTYMK","release_manifest":"api/v1.1/release_manifest.json"}},"DUBR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUBR","identifiers":{"aliases":[],"approved_symbol":"DUBR","ensembl_gene_id":"ENSG00000243701","hgnc_id":"HGNC:48569","ncbi_gene_id":344595,"previous_symbols":["LINC00883"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUBR","release_manifest":"api/v1.1/release_manifest.json"}},"DUOX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUOX1","identifiers":{"aliases":["NOXEF1","THOX1","LNOX1"],"approved_symbol":"DUOX1","ensembl_gene_id":"ENSG00000137857","hgnc_id":"HGNC:3062","ncbi_gene_id":53905,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUOX1","release_manifest":"api/v1.1/release_manifest.json"}},"DUOXA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUOXA1","identifiers":{"aliases":["FLJ32334","NUMBIP","NIP","mol"],"approved_symbol":"DUOXA1","ensembl_gene_id":"ENSG00000140254","hgnc_id":"HGNC:26507","ncbi_gene_id":90527,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DUOXA1","release_manifest":"api/v1.1/release_manifest.json"}},"DUPD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUPD1","identifiers":{"approved_symbol":"DUPD1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/DUPD1","release_manifest":"api/v1.1/release_manifest.json"}},"DUS1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUS1L","identifiers":{"aliases":["PP3111","DUS1"],"approved_symbol":"DUS1L","ensembl_gene_id":"ENSG00000169718","hgnc_id":"HGNC:30086","ncbi_gene_id":64118,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUS1L","release_manifest":"api/v1.1/release_manifest.json"}},"DUS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUS2","identifiers":{"aliases":["FLJ20399","SMM1"],"approved_symbol":"DUS2","ensembl_gene_id":"ENSG00000167264","hgnc_id":"HGNC:26014","ncbi_gene_id":54920,"previous_symbols":["DUS2L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUS2","release_manifest":"api/v1.1/release_manifest.json"}},"DUS3L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUS3L","identifiers":{"aliases":["DUS3","FLJ13896"],"approved_symbol":"DUS3L","ensembl_gene_id":"ENSG00000141994","hgnc_id":"HGNC:26920","ncbi_gene_id":56931,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUS3L","release_manifest":"api/v1.1/release_manifest.json"}},"DUS4L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUS4L","identifiers":{"aliases":["PP35","DUS4"],"approved_symbol":"DUS4L","ensembl_gene_id":"ENSG00000105865","hgnc_id":"HGNC:21517","ncbi_gene_id":11062,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUS4L","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP1","identifiers":{"aliases":["HVH1","CL100","MKP-1"],"approved_symbol":"DUSP1","ensembl_gene_id":"ENSG00000120129","hgnc_id":"HGNC:3064","ncbi_gene_id":1843,"previous_symbols":["PTPN10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP1","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP10","identifiers":{"aliases":["MKP-5","MKP5"],"approved_symbol":"DUSP10","ensembl_gene_id":"ENSG00000143507","hgnc_id":"HGNC:3065","ncbi_gene_id":11221,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP10","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP11","identifiers":{"aliases":["PIR1"],"approved_symbol":"DUSP11","ensembl_gene_id":"ENSG00000144048","hgnc_id":"HGNC:3066","ncbi_gene_id":8446,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP11","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP12","identifiers":{"aliases":["YVH1","DUSP1"],"approved_symbol":"DUSP12","ensembl_gene_id":"ENSG00000081721","hgnc_id":"HGNC:3067","ncbi_gene_id":11266,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP12","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP13","identifiers":{"approved_symbol":"DUSP13","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP13","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP14","identifiers":{"aliases":["MKP-L","MKP6"],"approved_symbol":"DUSP14","ensembl_gene_id":"ENSG00000276023","hgnc_id":"HGNC:17007","ncbi_gene_id":11072,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP14","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP15","identifiers":{"aliases":["bA243J16.6","VHY","FLJ20645","bA243J16.5"],"approved_symbol":"DUSP15","ensembl_gene_id":"ENSG00000149599","hgnc_id":"HGNC:16236","ncbi_gene_id":128853,"previous_symbols":["C20orf57"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DUSP15","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP16","identifiers":{"aliases":["MKP-7","KIAA1700","MKP7"],"approved_symbol":"DUSP16","ensembl_gene_id":"ENSG00000111266","hgnc_id":"HGNC:17909","ncbi_gene_id":80824,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP16","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP18","identifiers":{"aliases":["DUSP20"],"approved_symbol":"DUSP18","ensembl_gene_id":"ENSG00000167065","hgnc_id":"HGNC:18484","ncbi_gene_id":150290,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP18","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP19","identifiers":{"aliases":["SKRP1","DUSP17"],"approved_symbol":"DUSP19","ensembl_gene_id":"ENSG00000162999","hgnc_id":"HGNC:18894","ncbi_gene_id":142679,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP19","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP2","identifiers":{"aliases":["PAC-1"],"approved_symbol":"DUSP2","ensembl_gene_id":"ENSG00000158050","hgnc_id":"HGNC:3068","ncbi_gene_id":1844,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP2","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP22","identifiers":{"aliases":["MKPX","JSP1","JKAP","VHX"],"approved_symbol":"DUSP22","ensembl_gene_id":"ENSG00000112679","hgnc_id":"HGNC:16077","ncbi_gene_id":56940,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP22","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP23","identifiers":{"aliases":["FLJ20442","DUSP25"],"approved_symbol":"DUSP23","ensembl_gene_id":"ENSG00000158716","hgnc_id":"HGNC:21480","ncbi_gene_id":54935,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP23","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP26","identifiers":{"aliases":["MGC1136","DUSP24","NEAP"],"approved_symbol":"DUSP26","ensembl_gene_id":"ENSG00000133878","hgnc_id":"HGNC:28161","ncbi_gene_id":78986,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP26","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP27","identifiers":{"approved_symbol":"DUSP27","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DUSP27","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP28","identifiers":{"aliases":["VHP","DUSP26"],"approved_symbol":"DUSP28","ensembl_gene_id":"ENSG00000188542","hgnc_id":"HGNC:33237","ncbi_gene_id":285193,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP28","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP3","identifiers":{"aliases":[],"approved_symbol":"DUSP3","ensembl_gene_id":"ENSG00000108861","hgnc_id":"HGNC:3069","ncbi_gene_id":1845,"previous_symbols":["VHR"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP3","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP4","identifiers":{"aliases":["HVH2","MKP-2","TYP"],"approved_symbol":"DUSP4","ensembl_gene_id":"ENSG00000120875","hgnc_id":"HGNC:3070","ncbi_gene_id":1846,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP4","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP5","identifiers":{"aliases":["HVH3"],"approved_symbol":"DUSP5","ensembl_gene_id":"ENSG00000138166","hgnc_id":"HGNC:3071","ncbi_gene_id":1847,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP5","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP6","identifiers":{"aliases":["MKP-3","PYST1"],"approved_symbol":"DUSP6","ensembl_gene_id":"ENSG00000139318","hgnc_id":"HGNC:3072","ncbi_gene_id":1848,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DUSP6","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP7","identifiers":{"aliases":["MKP-X","PYST2"],"approved_symbol":"DUSP7","ensembl_gene_id":"ENSG00000164086","hgnc_id":"HGNC:3073","ncbi_gene_id":1849,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP7","release_manifest":"api/v1.1/release_manifest.json"}},"DUSP8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUSP8","identifiers":{"aliases":["HVH-5","HB5","FLJ42958"],"approved_symbol":"DUSP8","ensembl_gene_id":"ENSG00000184545","hgnc_id":"HGNC:3074","ncbi_gene_id":1850,"previous_symbols":["C11orf81"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUSP8","release_manifest":"api/v1.1/release_manifest.json"}},"DUT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUT","identifiers":{"aliases":["dUTPase"],"approved_symbol":"DUT","ensembl_gene_id":"ENSG00000128951","hgnc_id":"HGNC:3078","ncbi_gene_id":1854,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DUT","release_manifest":"api/v1.1/release_manifest.json"}},"DUXA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUXA","identifiers":{"aliases":[],"approved_symbol":"DUXA","ensembl_gene_id":"ENSG00000258873","hgnc_id":"HGNC:32179","ncbi_gene_id":503835,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/DUXA","release_manifest":"api/v1.1/release_manifest.json"}},"DUXAP8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DUXAP8","identifiers":{"aliases":[],"approved_symbol":"DUXAP8","ensembl_gene_id":"ENSG00000271672","hgnc_id":"HGNC:32187","ncbi_gene_id":503637,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DUXAP8","release_manifest":"api/v1.1/release_manifest.json"}},"DVL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DVL1","identifiers":{"aliases":[],"approved_symbol":"DVL1","ensembl_gene_id":"ENSG00000107404","hgnc_id":"HGNC:3084","ncbi_gene_id":1855,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DVL1","release_manifest":"api/v1.1/release_manifest.json"}},"DVL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DVL2","identifiers":{"aliases":[],"approved_symbol":"DVL2","ensembl_gene_id":"ENSG00000004975","hgnc_id":"HGNC:3086","ncbi_gene_id":1856,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DVL2","release_manifest":"api/v1.1/release_manifest.json"}},"DVL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DVL3","identifiers":{"aliases":["KIAA0208"],"approved_symbol":"DVL3","ensembl_gene_id":"ENSG00000161202","hgnc_id":"HGNC:3087","ncbi_gene_id":1857,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DVL3","release_manifest":"api/v1.1/release_manifest.json"}},"DXO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DXO","identifiers":{"aliases":["DOM3L"],"approved_symbol":"DXO","ensembl_gene_id":"ENSG00000204348","hgnc_id":"HGNC:2992","ncbi_gene_id":1797,"previous_symbols":["DOM3Z"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DXO","release_manifest":"api/v1.1/release_manifest.json"}},"DYDC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYDC2","identifiers":{"aliases":["bA36D19.6","MGC16186"],"approved_symbol":"DYDC2","ensembl_gene_id":"ENSG00000133665","hgnc_id":"HGNC:23468","ncbi_gene_id":84332,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/DYDC2","release_manifest":"api/v1.1/release_manifest.json"}},"DYM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYM","identifiers":{"aliases":["FLJ20071","DMC","SMC"],"approved_symbol":"DYM","ensembl_gene_id":"ENSG00000141627","hgnc_id":"HGNC:21317","ncbi_gene_id":54808,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYM","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC1H1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC1H1","identifiers":{"aliases":["Dnchc1","HL-3","p22","DHC1","CMT2O"],"approved_symbol":"DYNC1H1","ensembl_gene_id":"ENSG00000197102","hgnc_id":"HGNC:2961","ncbi_gene_id":1778,"previous_symbols":["DNECL","DNCL","DNCH1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted; NMD scope support direct low power or caution","links":{"research_record":"gene/DYNC1H1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC1I1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC1I1","identifiers":{"aliases":["DNCIC1"],"approved_symbol":"DYNC1I1","ensembl_gene_id":"ENSG00000158560","hgnc_id":"HGNC:2963","ncbi_gene_id":1780,"previous_symbols":["DNCI1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNC1I1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC1I2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC1I2","identifiers":{"aliases":["DIC74"],"approved_symbol":"DYNC1I2","ensembl_gene_id":"ENSG00000077380","hgnc_id":"HGNC:2964","ncbi_gene_id":1781,"previous_symbols":["DNCI2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNC1I2","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC1LI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC1LI1","identifiers":{"aliases":[],"approved_symbol":"DYNC1LI1","ensembl_gene_id":"ENSG00000144635","hgnc_id":"HGNC:18745","ncbi_gene_id":51143,"previous_symbols":["DNCLI1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNC1LI1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC1LI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC1LI2","identifiers":{"aliases":[],"approved_symbol":"DYNC1LI2","ensembl_gene_id":"ENSG00000135720","hgnc_id":"HGNC:2966","ncbi_gene_id":1783,"previous_symbols":["DNCLI2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNC1LI2","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC2H1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC2H1","identifiers":{"aliases":["hdhc11","DHC2","DHC1b","DYH1B"],"approved_symbol":"DYNC2H1","ensembl_gene_id":"ENSG00000187240","hgnc_id":"HGNC:2962","ncbi_gene_id":79659,"previous_symbols":["DNCH2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNC2H1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNC2LI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNC2LI1","identifiers":{"aliases":["D2LIC","LIC3","CGI-60","DKFZP564A033"],"approved_symbol":"DYNC2LI1","ensembl_gene_id":"ENSG00000138036","hgnc_id":"HGNC:24595","ncbi_gene_id":51626,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNC2LI1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNLL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNLL1","identifiers":{"aliases":["hdlc1","DLC1","PIN","LC8","DLC8"],"approved_symbol":"DYNLL1","ensembl_gene_id":"ENSG00000088986","hgnc_id":"HGNC:15476","ncbi_gene_id":8655,"previous_symbols":["DNCL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DYNLL1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNLL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNLL2","identifiers":{"aliases":["MGC17810","Dlc2","DNCL1B","RSPH22"],"approved_symbol":"DYNLL2","ensembl_gene_id":"ENSG00000264364","hgnc_id":"HGNC:24596","ncbi_gene_id":140735,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNLL2","release_manifest":"api/v1.1/release_manifest.json"}},"DYNLRB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNLRB1","identifiers":{"aliases":["DNLC2A","ROBLD1"],"approved_symbol":"DYNLRB1","ensembl_gene_id":"ENSG00000125971","hgnc_id":"HGNC:15468","ncbi_gene_id":83658,"previous_symbols":["DNCL2A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNLRB1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNLRB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNLRB2","identifiers":{"aliases":["DNLC2B","ROBLD2"],"approved_symbol":"DYNLRB2","ensembl_gene_id":"ENSG00000168589","hgnc_id":"HGNC:15467","ncbi_gene_id":83657,"previous_symbols":["DNCL2B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNLRB2","release_manifest":"api/v1.1/release_manifest.json"}},"DYNLT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNLT1","identifiers":{"aliases":["Tctex-1","TCTEX1"],"approved_symbol":"DYNLT1","ensembl_gene_id":"ENSG00000146425","hgnc_id":"HGNC:11697","ncbi_gene_id":6993,"previous_symbols":["TCTEL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/DYNLT1","release_manifest":"api/v1.1/release_manifest.json"}},"DYNLT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYNLT3","identifiers":{"aliases":["TCTEX1L"],"approved_symbol":"DYNLT3","ensembl_gene_id":"ENSG00000165169","hgnc_id":"HGNC:11694","ncbi_gene_id":6990,"previous_symbols":["TCTE1L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYNLT3","release_manifest":"api/v1.1/release_manifest.json"}},"DYRK1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYRK1A","identifiers":{"aliases":[],"approved_symbol":"DYRK1A","ensembl_gene_id":"ENSG00000157540","hgnc_id":"HGNC:3091","ncbi_gene_id":1859,"previous_symbols":["DYRK1","DYRK","MNBH"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYRK1A","release_manifest":"api/v1.1/release_manifest.json"}},"DYRK1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYRK1B","identifiers":{"aliases":["MIRK"],"approved_symbol":"DYRK1B","ensembl_gene_id":"ENSG00000105204","hgnc_id":"HGNC:3092","ncbi_gene_id":9149,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYRK1B","release_manifest":"api/v1.1/release_manifest.json"}},"DYRK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYRK2","identifiers":{"aliases":[],"approved_symbol":"DYRK2","ensembl_gene_id":"ENSG00000127334","hgnc_id":"HGNC:3093","ncbi_gene_id":8445,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYRK2","release_manifest":"api/v1.1/release_manifest.json"}},"DYRK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYRK3","identifiers":{"aliases":["RED","REDK","hYAK3-2"],"approved_symbol":"DYRK3","ensembl_gene_id":"ENSG00000143479","hgnc_id":"HGNC:3094","ncbi_gene_id":8444,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYRK3","release_manifest":"api/v1.1/release_manifest.json"}},"DYRK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYRK4","identifiers":{"aliases":[],"approved_symbol":"DYRK4","ensembl_gene_id":"ENSG00000010219","hgnc_id":"HGNC:3095","ncbi_gene_id":8798,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DYRK4","release_manifest":"api/v1.1/release_manifest.json"}},"DYSF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DYSF","identifiers":{"aliases":["FER1L1"],"approved_symbol":"DYSF","ensembl_gene_id":"ENSG00000135636","hgnc_id":"HGNC:3097","ncbi_gene_id":8291,"previous_symbols":["LGMD2B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/DYSF","release_manifest":"api/v1.1/release_manifest.json"}},"DZANK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DZANK1","identifiers":{"aliases":["FLJ10600","dJ568F9.2","FLJ30892","bA189K21.8","ANKRD64"],"approved_symbol":"DZANK1","ensembl_gene_id":"ENSG00000089091","hgnc_id":"HGNC:15858","ncbi_gene_id":55184,"previous_symbols":["C20orf84","C20orf12"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DZANK1","release_manifest":"api/v1.1/release_manifest.json"}},"DZIP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DZIP1","identifiers":{"aliases":["KIAA0996","DZIP"],"approved_symbol":"DZIP1","ensembl_gene_id":"ENSG00000134874","hgnc_id":"HGNC:20908","ncbi_gene_id":22873,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DZIP1","release_manifest":"api/v1.1/release_manifest.json"}},"DZIP1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DZIP1L","identifiers":{"aliases":["FLJ32844","DZIP2"],"approved_symbol":"DZIP1L","ensembl_gene_id":"ENSG00000158163","hgnc_id":"HGNC:26551","ncbi_gene_id":199221,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DZIP1L","release_manifest":"api/v1.1/release_manifest.json"}},"DZIP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"DZIP3","identifiers":{"aliases":["hRUL138","PPP1R66"],"approved_symbol":"DZIP3","ensembl_gene_id":"ENSG00000198919","hgnc_id":"HGNC:30938","ncbi_gene_id":9666,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/DZIP3","release_manifest":"api/v1.1/release_manifest.json"}}}
